De Araujo Lab

Body-Brain Communication

Training Programs:

Artificial Intelligence and Emerging Technologies in Medicine

Neuroscience

Research: Body-brain cybernetics

Neuronal information flow between body and brain

How do signals originating within the internal and superficial layers of the body influence our decisions and actions? We study the neural networks that link body sensors to skeletomuscular effectors (“body-brain cybernetics”). Specifically, we make use of modern neurobiological tools to unveil the large-scale networks linking body parts to molecularly identified neurons in the brain. Methodologically, we use the vertebrate feeding system, including predatory hunting, to model body-brain communication. With clear behavioral readouts, feeding and prey capture are ideally suited for studying how body sensors generate motor actions.

Selected Publications

Zhang et al. (2022) An inter-organ neural circuit for appetite suppression.      Cell (In Press July 2022).

Han et al. (2018) A Neural Circuit for Gut-Induced Reward.      Cell 175(3):665-678.

Han et al. (2017). Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala.     Cell 168(1-2):311-324.

Tellez et al. (2016) Separate Circuitries Encode the Hedonic and Nutritional Values of Sugar.     Nature Neuroscience 19(3):465-70.

Han et al. (2016) Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite.    Cell Metabolism 23(1):103-12.

Tellez et al. (2013) A gut lipid messenger links excess dietary fat to dopamine deficiency.     Science 341:800-2.

Ivan De Araujo, DPhil

Professor of Neuroscience

Location
Annenberg 19-10 1468 Madison Av. NYC 10029

Email
Ivan.DeAraujo@mssm.edu

Projects

Enteric Neural Networks: To identify and control epithelial and myenteric cell types in gut that regulate gastrointestinal movement and secretory activity.

Intravital Imaging of peripheral organs: In vivo monitoring of the activity and proliferation of neurons residing in gastrointestinal and other visceral organs.

Gut-Brain Communication: To control identified neuron types in periphery that drive acceptance and rejection cranial motor behaviors.

Neuronal control of bite force: To control identified neuron types in brain that convert firing patterns into mandibular mechanical force.

Meet the Team

Ivan De Araujo, DPhil

Ivan De Araujo, DPhil

Professor of Neuroscience

Wenfei Han

Wenfei Han

Assistant Professor of Neuroscience

Matthew Perkins, PhD

Matthew Perkins, PhD

Instructor

Hao Chang, PhD

Hao Chang, PhD

PostDoctoral Fellow

Leonardo Santana Novaes, PhD

Leonardo Santana Novaes, PhD

PostDoctoral Fellow

Tong Zhang, MD

Tong Zhang, MD

Visiting Scholar

Carolina Zaniboni, BSc.

Carolina Zaniboni, BSc.

Visiting Graduate Student

Wanqing Du, MD

Wanqing Du, MD

Visiting Graduate Student