Aging & Metabolism
Our laboratory studies mechanisms linking lifespan with age-related diseases, and particularly mechanisms by which dietary restriction increases lifespan and concomitantly delays age-related diseases across a wide range of species and diseases, even engineered diseases. Based on great progress in elucidating these mechanisms, the laboratory is increasingly turning to drug discovery, focusing on Alzheimer’s Disease and other age-related diseases in which overactive innate immunity is implicated.
Charles V Mobbs, PhD
Professor, Neuroscience, Endocrinology, Geriatrics, Pharmacology and Therapeutics Discovery
Lab: Hess 10-301
Office: Hess 9-119
Society for Science Regeneron Science Talent Search 2021
Noah Getz, Age: 17
Bronx High School of Science, NY
Project Title: A Novel High Throughput Method for Prescreening Drugs: Using Machine Learning to Predict Phenothiazines That Reduce TNF-ALPHA Secretion with Applications for Alzheimer’s Disease and COVID-19 Treatment
For his research where he adjusted the way computer models identify promising pharmaceutical compounds, which could make the discovery of new drugs faster and less expensive. Noah’s method treats classification as an information retrieval task, similar to the ranking results from a browser search. When he tested his model, it identified two drugs that might dramatically reduce the levels of an inflammation marker implicated in both Alzheimer’s disease and COVID-19.
Top 300 Scholar
Charles Brown, Age: 17
Ossining High School, NY
Project Title: The Validation of Electrodermal Activity as an Objective Measurement of Generalized Anxiety Disorder in Adolescents
Ko F, Isoda F, Mobbs C. Laparotomy in Mice Induces Blood Cell Expression of Inflammatory and Stress Genes. Journal of interferon & cytokine research. 2015 Apr;35(4):302-12. doi: 10.1089/jir.2014.0031. Epub 2014 Nov 19. Surgical trauma induces immune and stress responses although its effects on postsurgical inflammatory and stress gene expression remain poorly characterized. This study sought to improve current scientific knowledge by investigating the effects of laparotomy on mouse blood cell inflammatory and stress gene expression.