Rudebeck Lab

Neurobiology of Emotion & Cognition


rudebeckIn our daily lives we often encounter both pleasurable and aversive situations, which heighten our emotional state and affect cognition. The ability to flexibly regulate our emotions in response to such events is essential for adapting to our environment and, ultimately, for our mental health. Many forms of mental illness involve dysfunction in the neural systems that regulate affective processing and decision making. The limbic system, which includes parts of the prefrontal cortex and medial temporal lobe, is critical for regulating emotions and plays an essential role in cognition. The main focus of the Rudebeck lab is to understand how interaction between the prefrontal cortex and subcortical structures such as the amygdala contribute to emotional regulation and decision-making. To do this, we use a combination of behavioral, autonomic, neurophysiological and interference methods in animal models.

Rudebeck Laboratory
Peter H Rudebeck, PhD
Associate Professor, Neuroscience
Associate Professor, Psychiatry
Lab: HESS CSM 10-203A
Office: HESS CSM 10-112
Office: 212.824.9307
Lab: 212.824.9184


Featured Publications

A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Rudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA (2014) PNAS 111(14) 5391–5396

Featured Publications


In press / BioRxiv

Catherine Elorette*, Atsushi Fujimoto*, Frederic M. Stoll, Satoka H. Fujimoto, Lazar Fleysher, Niranjana Bienkowska, Brian E. Russ+, and Peter H. Rudebeck+ (2023) The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation. bioRxiv 


Frederic M. Stoll and Peter H. Rudebeck (2023) Preferences reveal separable valuation systems in prefrontal-limbic circuits. bioRxiv  

Matthew G. Perich, Charlotte Arlt, Sofia Soares, Megan E. Young, Clayton P. Mosher, Juri Minxha, Eugene Carter, Ueli Rutishauser, Peter H. Rudebeck, Christopher D. Harvey, Kanaka Rajan (2020) Inferring brain-wide interactions using data-constrained recurrent neural network models. BioRxiv

Frederic M. Stoll, Clayton P. Mosher, Sarita Tamang, Elisabeth A. Murray, and Peter H. Rudebeck (2017) Amygdala plays distinct roles on prefrontal local field potential and single neuron encoding of reward-based decisions. bioRxiv 

Jamie Nagy, Mark G. Baxter, Christienne Damatac, Peter H. Rudebeck, and Paula L. Croxson (2017) Lack of sex differences in higher cognitive function in macaques. bioRxiv 


Zachary R Zeisler, Liza London, William G Janssen, J Megan Fredericks, Catherine Elorette, Atsushi Fujimoto, Huiqing Zhan, Brian E Russ, Roger L Clem, Patrick R Hof, Frederic M Stoll, and Peter H Rudebeck (2022) High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex. Neuron, in press

Megan E. Young*, Camille Spencer-Salmon*, Clayton Mosher, Sarita Tamang, Kanaka Rajan, and Peter H. Rudebeck (2023) Temporally-specific sequences of neural activity in interconnected corticolimbic structures during reward anticipation. Neuron, doi: 10.1016/j.neuron.2023.07.012


Peter H. Rudebeck and Alicia Izquierdo (2022) Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior. Neuropsychopharmacology, 47(1):134-146

Atsushi Fujimoto*, Catherine Elorette*, J. Megan Fredericks, Satoka H. Fujimoto, Lazar Fleysher, Peter H. Rudebeck+, and Brian E. Russ+ (2022) Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects. Journal of Neuroscience, 42(29):5705-5716


Eliza Bliss-Moreau and Peter H. Rudebeck (2020) Animal Models of Human Mood. Neuroscience Biobehavioral Reviews, (20) 30451-6

Catherine Elorette, Atsushi Fujimoto, J. Megan Fredericks, Frederic M. Stoll, Brian E. Russ, and Peter H. Rudebeck (2021) Piecing together the orbitofrontal puzzle. Behavioral Neuroscience, 135(2):301-311

Atsushi Fujimoto, Elisabeth A. Murray, and Peter H. Rudebeck (2021) Interaction between decision-making and interoceptive representations of arousal in frontal cortex. Proceedings of the National Academy of the Sciences USA, 118(35): e2014781118

Kevin Norman, Hiroyuki Koike, Julia Bateh, Sarah Lopez, Keaven Caro, Daisuke Kato, Kazuhiko Yamamuro, Meghan Flanigan, Yury Garkun, Elisa Nabel, Daniel Brady, Christina Cho, Justin Riceberg, Masato Sadahiro, Michael Demars, Matthew Shapiro, Scott Russo, Mark Baxter, Peter Rudebeck, Hirofumi Morishita (2021) Post-error Recruitment of Frontal-sensory Cortical Projection Promotes Attentional Behavior. Neuron, 109(7):1202-1213

Joseph Simon IV, Peter H Rudebeck, Erin L. Rich (2021) From affective to cognitive processing: Functional organization of the medial frontal cortex. International Review of Neurobiology, 158:1-28


Danielle Beckman, Kristine Donis-Cox, Sean Ott, Mary Roberts, Lisa Novik, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison (2019) Quantitative analysis of synaptic pathology and neuroinflammation: an initial study in a female rhesus monkey model of the synaptic phase of Alzheimer′s Disease. Proceedings of the National Academy of Sciences of the USA, doi: 10.1073/pnas.1902301116

Peter H. Rudebeck, Erin L. Rich, Helen S. Mayberg (2019) From bed to bench side: reverse translation for mood disorders neuromodulation therapies. Proceedings of the National Academy of Sciences of the USA, doi: 10.1073/pnas.1902287116

Frederic M. Stoll and Peter H. Rudebeck (2019) The value of persistent value. Neuron, 103(5):757-758

Megan Fredericks, Atsushi Fujimoto, and Peter H. Rudebeck (2019) Trust, but verify: a cautionary tale of translating chemogenetics. European Journal of Neuroscience. 50(5):2751-2754

Maia S. Pujara, Peter H. Rudebeck, Nicole K. Ciesinski, and Elisabeth A. Murray (2018) Heightened defensive responses following subtotal lesions of macaque orbitofrontal cortex. Journal of Neuroscience, 39 (21) 4133-414


Peter H. Rudebeck and Erin L. Rich (2018) Primer on OFCCurrent Biology, 28(18):R1083-R1088

James J Young, Peter H Rudebeck, Lara V Marcuse, Madeline C Fields, Ji Yeoun Yoo, Fedor Panov, Saadi Ghatan, Arash Fazl, Sarah Mandelbaum, Mark G Baxter (2018) A Theta Band Network Involving Prefrontal Cortex Unique to Human Episodic Memory. Neuroimage, 183:565-573

Nicholas Upright, Stephen Brookshire, Wendy Schnebelen, Christienne Damatac, Patrick Hof, Philip G. Browning, Paula L. Croxson, Peter H. Rudebeck, and Mark G. Baxter (2018) Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys. Journal of Neuroscience, 38(37):7969-7975

Elisabeth A. Murray and Peter H. Rudebeck (2018) Specializations for value-based decision making in the primate ventral prefrontal cortexNature Reviews Neuroscience, 19(7): 404-417

Erin L. Rich, Frederic M. Stoll, and Peter H. Rudebeck (2018) Linking dynamic patterns of neural activity in orbitofrontal cortex with decision making. Current Opinion in Neurobiology. 49:24-32 (


Peter H. Rudebeck, Richard C. Saunders, Dawn A. Lundgren, and Elisabeth A. Murray (2017) Specialized representations of value in orbital and ventrolateral prefrontal cortex: desirability versus availability of outcomes. Neuron, 95(5): 1208-1220

Peter H. Rudebeck, Joshua A. Ripple, Andrew R. Mitz, Bruno B. Averbeck, and Elisabeth A. Murray (2017) Amygdala contributions to stimulus–reward encoding in the macaque medial and orbital frontal cortex during learning. Journal of Neuroscience, 37(8): 2186-2202

Andrew R. Mitz, Ravi V. Chako, Philip T. Putnam, Peter H. Rudebeck, and Elisabeth A. Murray (2017) Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments. Journal of Neuroscience Methods, 279:1-12

Alicia Izquierdo, Jonathan L. Brigman, Anna K. Radke, Peter H. Rudebeck, and Andrew Holmes (2017) The neural basis of reversal learning: An updated perspective. Neuroscience, 345:12-26


Vincent D. Costa and Peter H. Rudebeck (2016) More than meets the eye: the relationship between pupil size and locus coerulus activity. Neuron, 89(1): 8-10


Anthony I. Jang, Vincent D. Costa, Peter H. Rudebeck, Yogita Chudasama, Elisabeth A. Murray, and Bruno B. Averbeck (2015) The role of frontal cortical and medial-temporal lobe brain areas in learning a Bayesian prior belief on reversals, Journal of Neuroscience, 35(33): 11751-11760

Clayton Mosher and Peter H. Rudebeck (2015) New tricks for an old structure: the amygdala accountant. Nature Neuroscience, 18(3): 324-5


neuron dec 2014 vol84-6Rudebeck, PH and Murray, E.A. (2014) The Orbitofrontal Oracle: Cortical Mechanisms for the Prediction and Evaluation of Specific Behavioral Outcomes. Neuron, 84(6):1143-1156 doi: 10.1016/j.neuron.2014.10.049.

pnas 04 2014 vol111 14 coverRudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA. A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the United States of America 2014 Apr; 111(14).

hippocampusTianming Yang, Rachel Bavley, Kevin Fomalont, Kevin Blomstrom, Andrew R Mitz, Janita Turchi, Peter H Rudebeck and Elisabeth A Murray (2014) Contributions of the hippocampus and entorhinal cortex to rapid associative learning in rhesus monkeys. Hippocampus, doi: 10.1002/hipo.22294.

Peter H Rudebeck, Philip T Putnam, Teresa E Daniels, Tianming Yang, Andrew R Mitz, Sarah EV Rhodes and Elisabeth A Murray (2014) A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the USA, 111(14): 5391-6.


Peter H Rudebeck, Andrew R Mitz, Ravi V Chacko and Elisabeth A Murray (2013) Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex. Neuron, 80(6): 1519-31.

Peter H Rudebeck, Richard C Saunders, Anna T. Prescott, Lily S. Chau and Elisabeth A Murray (2013) Prefrontal mechanisms of emotion, value and behavioural flexibility. Nature Neuroscience, 16(8): 1140-5.

Elisabeth A Murray and Peter H Rudebeck (2013) Strive to drive: goal generation based on current needs. Frontiers in Neuroscience, 7: 112.

Alicia Izquierdo, Chelsi Darling, Nic Manos, Hilda Pozos, Charissa Kim, Serena Ostrander, Victor Cazares, Haley Stepp, Peter H Rudebeck (2013) Basolateral amygdala lesions facilitate and orbitofrontal cortex lesions impair responses after negative feedback in rats. Journal of Neuroscience, 33(9): 4105-9.

Yogita Chudasama, Teresa E Daniels, Daniel P Gorrin, Sarah EV Rhodes, Peter H Rudebeck, and Elisabeth A Murray (2013) Anterior cingulate cortex lesions in rhesus monkeys fail to disrupt choices guided by changes in reward value and reward contingency. Cerebral Cortex, 23(12): 2884-98.


Peter H Rudebeck and Elisabeth A Murray (2011) Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting values. Annals of the New York Academy of Sciences, 1239(1): 1-13.

Mark E. Walton, Timothy E. J. Behrens, Peter H. Rudebeck, & Matthew F. S. Rushworth (2011) Cingulate and orbitofrontal contributions to valuing knowns and unknowns in a changeable world. Attention & Performance XXIII: Decision Making. OUP, Oxford.

Peter H Rudebeck and Elisabeth A Murray (2011) Dissociable effects of subtotal lesions within the macaque orbitofrontal cortex on reward-guided behaviour. Journal of Neuroscience, 31(29): 10569-10578.

2010 and before

MaryAnn P Noonan, Jerome Sallet, Peter H Rudebeck, Mark J Buckley, Matthew F Rushworth (2010) Does the medial orbitofrontal cortex have a role in social valuation? European Journal of Neuroscience, 31(12): 2341-51

Mark E Walton, Timothy E Behrens, Mark J Buckley, Peter H Rudebeck and Matthew FS Rushworth (2010) Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning. Neuron, 65(6): 927-39

Timothy Y Mariano, Mark G Baxter, Stephen B McHugh, Mark E Walton, Sarah R Rudebeck, Peter H Rudebeck, Matthew F Rushworth, J Nicholas Rawlins, Thomas G Campbell, David M Bannerman (2009) Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a non-spatial decision making maze task. European Journal of Neuroscience, 30(3): 472-84

Peter H Rudebeck, Timothy E Behrens, Steven W Kennerley, Mark G Baxter, Mark J Buckley, Mark E Walton, and Matthew F Rushworth (2008) Frontal cortex subregions play distinct roles in choices between actions and stimuli. Journal of Neuroscience, 28(51): 13775-85

Peter H Rudebeck, David M Bannerman, Matthew F Rushworth (2008) The contribution of distinct subregions of ventromedial frontal cortex to emotion, social behavior and decision-making. Cognitive, Affective and Behavioral Neuroscience 8 (4): 485-497

Peter H Rudebeck, Elisabeth A Murray (2008) Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learning. Journal of Neuroscience, 28(33): 8338–8343

Peter H Rudebeck, Mark E Walton, Benjamin HP Millette, Elizabeth Shirley, Matthew F Rushworth, David M Bannerman (2007) Distinct contributions of frontal areas to emotion and social behaviour. European Journal of Neuroscience, 26(8): 2315-26

Mark E Walton, Peter H Rudebeck, David M Bannerman, & Matthew F S Rushworth (2007) Calculating the cost of acting in the prefrontal cortex. Annals of the New York Academy of Science, 1104: 340-56

Matthew FS Rushworth, Timothy EJ Behrens, Peter H Rudebeck and Mark E Walton (2007) Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends in Cognitive Science, 11(4): 168-76

Peter H Rudebeck, Mark J Buckley, Mark E Walton and Matthew F Rushworth (2006) A role for the macaque anterior cingulate gyrus in social valuation. Science, 313(5791): 1310-2

Peter H Rudebeck, Mark E Walton, Angharad N Smyth, David B Bannerman, Matthew F Rushworth (2006) Separate neural pathways process different decision costs. Nature Neuroscience, 9(9): 1161-8

Narender Ramnani, Timothy EJ Behrens, Heidi Johansen-Berg, Marlene C Richter, Mark A Pinsk, Jesper LR Andersson, Peter Rudebeck, Olga Ciccarelli, Wolfgang Richter, Alan J Thompson, Charles G Gross, Mark D Robson, Sabine Kastner and Paul M Matthews (2005) The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from macaque monkeys and humans. Cerebral Cortex, 16(6): 811-8

Meet the Team

Davide Folloni, DPhil

Davide Folloni, DPhil

Postdoctoral Fellow

Atsushi Fujimoto, MD PhD

Atsushi Fujimoto, MD PhD


Frederic M Stoll, PhD

Frederic M Stoll, PhD


Catherine Elorette, PhD

Catherine Elorette, PhD

Postdoctoral Fellow

Satoka Hashimoto Fujimoto, MD PhD

Satoka Hashimoto Fujimoto, MD PhD

Postdoctoral Fellow

Khadijah Crawford

Khadijah Crawford

MD/PhD Student

Zach Zeisler

Zach Zeisler

PhD Student

News, Funding, Job Opportunities

July, 2019          Postdoctoral fellow Dr Catherine Elorette joins the lab

June, 2019        Master’s student Jairo Munoz passes his Masters thesis defense

May, 2019        PREP student Khadijah Crawford presents poster at North East PREP meeting

April, 2019               Postdoctoral fellow Dr Atsushi Fujimoto joins the lab on a Takeda Foundation Fellowship

January, 2019          With Rich and Rajan Labs, Rudebeck lab wins Di Sabato Family Research Fellowship from Friedman Brain Institute

October, 2018          Fred Stoll presents a poster at the Computational Properties of the Prefrontal Cortex (CPPC) meeting, in Nashville, TN

September, 2018     Lab receives joint BRAIN Initiative grant with Dr Brian Russ to study the mechanistic and causal basis of fMRI functional connectivity

April, 2018                Erin Rich, Fred and Pete publish review in Current Opinion in Neurobiology

November, 2017       Megan (Young), Fred, and Megan (Fredericks) present at the 2017 Society for Neuroscience meeting in Washington, DC

November, 2017      Pete wins the Janine Rosenberg Trubach Career Development Award from the Society for Neuroscience

November, 2017      Rudebeck Lab Escape the room!

September, 2017       PhD rotation students Joe Simon and Megan Fredericks as well as PREP student Khadijah Crawford join the lab

July, 2017                  Rudebeck Lab conquer Bear Mountain!

01/15/2016 – 01/14/2018      Young Investigator Award Brain (Rudebeck, PI)
Behavior Research Foundation
Title: The Neurophysiology of Anhedonia
Goal: To determine how neural activity in a circuit linking prefrontal cortex and
limbic system is related to the anticipation of reward.

07/01/2016 – 3/31/2021        R01MH110822 (Rudebeck, PI)
NIMH Biobehavioral Research Awards for Innovative New Scientists (BRAINS)
Title: A new approach to the role of prefrontal-limbic circuits in anxiety disorders.
Goal: To determine the mechanistic and causal basis of how the brain processes
information about the potential for both negative and positive events to occur.

03/24/2017 – 02/28/2019          R21MH112539 (Rudebeck,PI)
Title: Neural mechanisms of social affect induction
Goal: To determine how inducing temporally extended affective states in macaque
monkeys affects activity in circuits linking prefrontal cortex and limbic system.


02/2017 – 02/2018                     Rosen Family Scholar
Friedman Brain Institute Scholars
Title: Neural mechanisms of human higher cognitive function
Goal: This project aims to determine the patterns of neural activity, both single
neuron and local field potentials, that support working memory in humans.