Akbarian Laboratory of Epigenetic Regulation of the Human Brain

Research

“We explore epigenetic regulation of gene expression, in order to identify epigenetic drug targets and novel treatment avenues for psychosis, depression and other psychiatric disease.”

— Schahram Akbarian, MD PHD
[Principal Investigator]

Contact us

Akbarian Laboratory
Schahram Akbarian, MD, PhD
Professor, Psychiatry
Professor, Neuroscience
Location
Office: HESS 9-105
Phone
Office: 212.824.8984
Email

Principal Investigator

Schahram Akbarian, MD, PhD

Schahram Akbarian, MD, PhD

Professor, Psychiatry & Neuroscience

schahram.akbarian@mssm.edu

Education

Internship, General Medicine Beth — Israel Medical Center

Residency, Psychiatry — Massachusetts General Hospital

Biography

Schahram Akbarian studied medicine and conducted his thesis work on the central representation of the primate vestibular system at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. In 2002, he joined the University of Massachusetts Medical School in Worcester where he established a research program in psychiatric epigenetics and served as the Director of the Brudnick Neuropsychiatric Research Institute. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine.

Awards

  • Kleman award, Brain & Behavior Research Foundation
  • Judith Silver Memorial award, National Alliance for the Mentally Ill
  • Outstanding Resident award, NIMH
  • Eva King Killan Research award, American College of Neuropsychopharmacology

PsychENCODE

The Akbarian lab, in collaboration with a few others across the country, is spearheading PsychENCODE. For more information, visit psychencode.org.

Featured

Conserved higher order chromatin regulates NMDA receptor gene expression and cognition

Bharadwaj, R*, Peter CJ*, Jiang Y*, Roussos P, Vogel-Cierna A, Shen E, Mitchell A, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, Akbarian S (* share first authorship)

Publications

2017

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ (2017) Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry pii: S0006-3223(17)31517-2. doi: 10.1016/j.biopsych.2017.04.013. [Epub ahead of print] PMID: 28577753.


Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K (2017) Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nat Commun 8:15142. doi: 10.1038/ncomms15142. PMID: 28485378.


McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network (2017) Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science 356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review. PMID: 28450582.


Powell SK, Gregory J, Akbarian S, Brennand KJ (2017) Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease. Mol Cell Neurosci 82:157-166. doi: 10.1016/j.mcn.2017.05.007. [Epub ahead of print] Review. PMID:28549865.


Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Yiang J, Brennand KJ, Neve RL, Gonzalez-Maeso J, Akbarian S (2017) MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Mol Psychiatry [Epub ahead of print]. PMID:28115742.

2016

Schmitt A, Martins-de-Souza D, Akbarian S, Cassoli JS, Ehrenreich H, Fischer A, Fonteh A, Gattaz WF, Gawlik M, Gerlach M, Grünblatt E, Halene T, Hasan A, Hashimoto K, Kim YK, Kirchner SK, Kornhuber J, Kraus TF, Malchow B, Nascimento JM, Rossner M, Schwarz M, Steiner J, Talib L, Thibaut F, Riederer P, Falkai P; Members of the WFSBP Task Force on Biological Markers. (2016) Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms. World J Biol Psychiatry [Epub ahead of print]. PMID:27782767.


Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S (2016) DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry 80(10):765-774. PMID:27184921.


Rajarajan P, Gil SE, Brennand KJ, Akbarian S (2016) Spatial genome organization and cognition. Nat Rev Neurosci 17(11):681-691. PMID:27708356.


Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P (2016) Disruption of an Evolutionary Novel Synaptic Expression Pattern in Autism. PLoS Biol 14(9):e1002558. PMID:27685936


Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S (2016) Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun 7:12743. PMID:27597321.


Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S (2016) Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety. Neuropsychopharmacology [Epub ahead of print]. PMID:27485686.


Chandrasekaran S, Akbarian S (2016) Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biol Psychiatry 80(4):260-2. PMID:27468627.


Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH (2016) Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One 11(7):e0160295. PMID: 27454300.


Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O’Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK (2016) Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry 80(2):84-6. PMID:27346079.


Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S (2016) DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry pii:S0006-3223(16)32233-8. PMID:27184921.


Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, Fromer M, Harris B, Lipska BK, Peters MA, Sklar P, Akbarian S (2016) Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue. Biol Psychiatry pii:S0006-3223(16)31098-8. PMID: 27113501.


Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P (2016) Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophr Res pii:S0920-9964(16)30039-1. Review. PMID: 26827128.


Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S (2016) NeuN + neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure. Schizophr Res pii S0920-9964(15)30089-X. [ Epub ahead of print] PMID: 26776227


Jakovcevski M,  Akbarian S, Di Benedetto B (2016) Pharmacological modulation of astrocytes and the role of cell-type-specific histone modifications for the treatment of mood disorders. Curr Opin Pharmacol 26:61-6. Review. PMID: 26515273 .

2015

Sharp AJ, Akbarian S (2015) Back to the past in schizophrenia genomics. Nat Neurosci 19(1):1-2. PMID: 26713739


Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH (2015) RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One 10(12):e0143563.eCollection 2015. PMID: 26636579 .


Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z (2015) The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease. PLoS One 10(12):e0144398. PMID: 26636336

Bicks LK, Koike H, Akbarian S, Morishita H (2015) Prefrontal Cortex and Social Cognition in Mouse and Man. Front Psychol 6:1805eCollection 2015. Review. PMID: 26635701 .


Akbarian S , Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff -Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N (2015) The PsychENCODE project. Nat Neurosci 18(12):1707-12. PMID: 26605881


Akbarian S , Kundakovic M (2015) CHRNA7 and CHRFAM7A: Psychosis and Smoking? Blame the Neighbors! Am J Psychiatry 172(11):1054-6. PMID: 26575444


Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE, Akbarian S (2015) Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain. Transl Psychiatry 5:e679. PMID: 26575220 .


Nestler EJ, Peña CJ, Kundakovic M, Mitchell A, Akbarian S (2015) Epigenetic Basis of Mental Illness. Neuroscientist pii : 1073858415608147. [Epub ahead of print] Review. PMID: 26450593 .


de Boni L, Riedel L, Schmitt I, Kraus TF, Kaut O, Piston D, Akbarian S, Wüllner U (2015) DNA methylation levels of α- synuclein intron 1 in the aging brain. Neurobiol Aging 36(12):3334.e7-3334.e11. PMID: 26422361


Koike H, Demars MP, Short JA, Nabel EM, Akbarian S, Baxter MG, Morishita H (2015) Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse. Neuropsychopharmacology doi : 10.1038/npp.2015.229. [Epub ahead of print] PMID: 26224620 .


Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR ,Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD (2015) Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron ;87 (1):77-94. doi : 10.1016/j.neuron.2015.06.014. PMID: 26139371


Mahajan S, Crisci J, Wong A, Akbarian S, Foll M, Jensen JD (2015) Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection. Front Genet 6:190. doi : 10.3389/fgene.2015.00190. eCollection 2015. PMID: 26074949 .


Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF,Akbarian S, Weng Z, Vonsattel JP, Myers RH (2015) miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics 8:10. doi : 10.1186/s12920-015-0083-3. PMID: 25889241


Shen EY, Jiang Y, Mao W, Futai K, Hock H, Akbarian S (2015) Cognition and mood-related behaviors in L3mbtl1 null mutant mice. PLoS One 10(4):e0121252. doi : 10.1371/journal.pone.0121252. eCollection 2015. PMID: 25849281 .


Morishita H, Kundakovic M, Bicks L, Mitchell A, Akbarian S (2015) Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia. Neurobiol Learn Mem 124:104-10. doi : 10.1016/j.nlm.2015.03.005. Epub 2015 Apr 4. Review. PMID: 25849095


Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD,  Akbarian S (2015) Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci 35(13):5097-108. doi : 10.1523/JNEUROSCI.3004-14.2015. PMID: 25834037


Hess JL, Quinn TP, Akbarian S, Glatt SJ (2015) Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 168B(1) :14 -35. doi : 10.1002/ajmg.b.32284. Review. PMID: 25522715


Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF (2015) Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet 24(5):1441-56. doi : 10.1093/hmg /ddu561. Epub 2014 Dec 5. PMID: 25480889


Mitchell AC, Jiang Y, Peter C, Akbarian S (2015) Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia. Schizophr Res 167(1-3):28-34. doi : 10.1016/j.schres.2014.10.020. Epub 2014 Oct 31. Review. PMID: 25458568 .


Amaral AC, Jakovcevski M, McGaughy JA, Calderwood SK, Mokler DJ, Rushmore RJ, Galler JR, Akbarian SA, Rosene DL (2015) Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex. Neuroscience 286:79-86. doi : 10.1016/j.neuroscience.2014.11.005. Epub 2014 Nov 18. PMID: 25446346 .


Shen EY, Ahern TH, Cheung I, Straubhaar J, Dincer A, Houston I, de Vries GJ, Akbarian S, Forger NG (2015) Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice. Exp Neurol 268:21-9. doi : 10.1016/j.expneurol.2014.08.006. Epub 2014 Aug 14. Review. PMID: 25131640

2014

Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel- Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA ,Akbarian S (2014) Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron 84(5):997-1008. doi : 10.1016/j.neuron.2014.10.032. Epub 2014 Nov 13. PMID: 25467983


Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Brennand KJ, Robakis NK, Schadt EE, Akbarian S, Sklar P (2014) A role for noncoding variation in schizophrenia. Cell Rep 9(4):1417-29. doi : 10.1016/j.celrep.2014.10.015. Epub 2014 Nov 6. PMID: 25453756


Akbarian S , Lubin F (2014) Preface. Epigenetics and neuroplasticity–evidence and debate. Prog Mol Biol Transl Sci 128:xi-xiii. doi : 10.1016/B978-0-12-800977-2.10000-2. No abstract available. PMID: 25410547


Mitchell A, Roussos P, Peter C, Tsankova N,  Akbarian S (2014) The future of neuroepigenetics in the human brain. Prog Mol Biol Transl Sci 128:199-228. doi : 10.1016/B978-0-12-800977-2.00008-5. Review. PMID: 25410546


Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, Dickson DW, Petrucelli L, Sun D, Jiao J, Zhou H, Jakovcevski M, Akbarian S, Yao WD, Gao FB (2014) Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med 20(12):1444-51. doi : 10.1038/nm.3717. Epub 2014 Nov 17. PMID: 25401692


Akbarian S (2014) Epigenetic mechanisms in schizophrenia. Dialogues Clin Neurosci 16(3):405-17. Review. PMID: 25364289


Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ (2014) Analytical tools and current challenges in the modern era of neuroepigenomics . Nat Neurosci 17(11):1476-90. doi : 10.1038/nn.3816. Epub 2014 Oct 28. Review. PMID: 25349914


Chen CT, Hehnly H, Yu Q, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S (2014) A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol 24(19):2327-34. doi : 10.1016/j.cub.2014.08.029. Epub 2014 Sep 11. PMID: 25220058


Shen E, Shulha H, Weng Z, Akbarian S (2014) Regulation of histone H3K4 methylation in brain development and disease. Philos Trans R Soc Lond B Biol Sci 369(1652). pii : 20130514. doi : 10.1098/rstb.2013.0514. Review. PMID: 25135975


Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF,Akbarian S, Chen JF, Weng Z, Myers RH (2014) MicroRNAs located in the Hox gene clusters are implicated in huntington’s disease pathogenesis. PLoS Genet 10(2):e1004188. doi : 10.1371/journal.pgen.1004188. eCollection 2014 Feb. PMID: 24586208


Ginns EI, Mak SK, Ko N, Karlgren J,  Akbarian S, Chou VP, Guo Y, Lim A, Samuelsson S, LaMarca ML, Vazquez- DeRose J, Manning-Boğ AB (2014) Neuroinflammation and α- synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Mol Genet Metab 111(2):152-62. doi : 10.1016/j.ymgme.2013.12.003. Epub 2013 Dec 11. PMID: 24388731


Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S (2014) The genome in three dimensions: a new frontier in human brain research. Biol Psychiatry 75(12):961-9. doi : 10.1016/j.biopsych.2013.07.015. Epub 2013 Aug 16. Review. PMID: 23958183


Tushir JS, Akbarian S (2014) Chromatin-bound RNA and the neurobiology of psychiatric disease. Neuroscience 264:131-41. doi : 10.1016/j.neuroscience.2013.06.051. Epub 2013 Jul 3. Review. PMID: 23831425 .

2013

Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD (2013) Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med 19(11):1473-7. doi : 10.1038/nm.3353. Epub 2013 Oct 20. PMID: 24141422 .


Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir JS, Liu J, Sequeira A, Vawter MP, Gardner PD, Casaccia P, Rasmussen T, Bunney WE Jr , Mirnics K, Futai K,  Akbarian S (2013) Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. J Neurosci 33(29):11839-51. doi : 10.1523/JNEUROSCI.1252-13.2013. PMID: 23864674


Jakovcevski M, Bharadwaj R, Straubhaar J, Gao G, Gavin DP, Jakovcevski I, Mitchell AC, Akbarian S (2013) Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. Biol Psychiatry 74(9):696-705. doi : 10.1016/j.biopsych.2013.03.020. Epub 2013 May 7. PMID: 23664640


Akbarian S , Halene T (2013) The neuroepigenetics of suicide. Am J Psychiatry 170(5) :462 -5. doi : 10.1176/appi.ajp.2013.13020235. No abstract available. PMID: 23632831 .


Shulha HP, Cheung I, Guo Y, Akbarian S, Weng Z (2013) Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood. PLoS Genet 9(4):e1003433. doi : 10.1371/journal.pgen.1003433. Epub 2013 Apr 11. PMID: 23593028


Akbarian S , Beeri MS, Haroutunian V (2013) Epigenetic determinants of healthy and diseased brain aging and cognition. JAMA Neurol 70(6):711-8. doi : 10.1001/jamaneurol.2013.1459. Review. PMID: 23571692


Hope BT, Skinner MK, Kenny PJ, Akbarian S (2013) Exploring the epigenetics of cocaine resistance. Nat Med 19(2):136-7. doi : 10.1038/nm.3091. No abstract available. PMID: 23389607 .


Hasan A, Mitchell A, Schneider A, Halene T, Akbarian S (2013) Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors. Eur Arch Psychiatry Clin Neurosci 263(4):273-84. doi : 10.1007/s00406-013-0395-2. Epub 2013 Feb 5. Review. PMID: 23381549 .


Akbarian S , Nestler EJ (2013) Epigenetic mechanisms in psychiatry. Neuropsychopharmacology 38(1):1-2. doi : 10.1038/npp.2012.185. No abstract available. PMID: 23147478


Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S (2013) Epigenetics in the human brain. Neuropsychopharmacology 38(1):183-97. doi : 10.1038/npp.2012.78. Epub 2012 May 30. PMID: 22643929

2012

Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S (2012) Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol 10(11):e1001427. doi : 10.1371/journal.pbio.1001427. Epub 2012 Nov 20. PMID: 23185133


Jakovcevski M, Akbarian S (2012) Epigenetic mechanisms in neurological disease. Nat Med 18(8):1194-204. doi : 10.1038/nm.2828. Review. PMID: 22869198


Connor CM, Dincer A, Straubhaar J, Galler JR, Houston IB, Akbarian S (2012) Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome . Schizophr Res 140(1-3):175-84. doi : 10.1016/j.schres.2012.06.037. Epub 2012 Jul 16. PMID: 22804924


Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11(3):319-32. doi : 10.1016/j.stem.2012.06.002. Epub 2012 Jul 5. PMID: 22770845


Rane P, Shields J, Heffernan M, Guo Y, Akbarian S, King JA (2012) The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology 62(7):2409-12. doi : 10.1016/j.neuropharm.2012.01.026. Epub 2012 Feb 13. PMID: 22353286


Gavin DP, Akbarian S (2012) Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease. Neurobiol Dis 46(2):255-62. doi : 10.1016/j.nbd.2011.12.008. Epub 2011 Dec 13. Review. PMID: 22182689


Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, Guo Y, Lessard A,  Akbarian S, Weng Z (2012) Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons. Arch Gen Psychiatry 69(3):314-24. doi : 10.1001/archgenpsychiatry.2011.151. Epub 2011 Nov 7. PMID: 22065254

Previous Publications

Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Caron MG, George SR, Allen JA, Solis M (2011) Advancing drug discovery for schizophrenia. Ann N Y Acad Sci 1236:30-43. doi : 10.1111/j.1749-6632.2011.06216.x. Erratum in: Ann N Y Acad Sci. 2012 Jul ;1259:145 . Saw, Akira [corrected to Sawa , Akira]. PMID: 22032400


Peter CJ, Akbarian S (2011) Balancing histone methylation activities in psychiatric disorders. Trends Mol Med 17(7):372-9. doi : 10.1016/j.molmed.2011.02.003. Epub 2011 Mar 21. Review. PMID: 21429800 .


Akbarian S (2010) Epigenetics of schizophrenia. Curr Top Behav Neurosci 4:611-28. PMID: 21312415


Yang C, Tan W, Whittle C, Qiu L, Cao L,  Akbarian S, Xu Z (2010) The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PLoS One 5(12):e15878. doi : 10.1371/journal.pone.0015878. PMID: 21209826


Akbarian S , Davis RJ (2010) Keep the ‘phospho ‘ on MAPK, be happy. Nat Med 16(11):1187-8. doi : 10.1038/nm1110-1187. No abstract available. PMID: 21052065 .


Jiang Y, Matevossian A, Guo Y, Akbarian S (2011) Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology 60(7-8):1088-97. doi : 10.1016/j.neuropharm.2010.09.020. Epub 2010 Sep 30. PMID: 20869373


Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S (2012) Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophr Bull 38(3):433-43. doi : 10.1093/ schbul /sbq091. Epub 2010 Aug 23. PMID: 20732949


Connor CM, Crawford BC, Akbarian S (2011) White matter neuron alterations in schizophrenia and related disorders. Int J Dev Neurosci 29(3):325-34. doi : 10.1016/j.ijdevneu.2010.07.236. Epub 2010 Aug 4. Review. PMID: 20691252


Huang HS, Cheung I, Akbarian S (2010) RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. Autism Res 3(4):153-61. doi : 10.1002/aur.141. PMID: 20632321


Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H (2010) Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem 285(36):27767-75. doi : 10.1074/jbc.M110.115410. Epub 2010 Jun 30. PMID: 20592034 .


Jiang Y, Jakovcevski M, Bharadwaj R, Connor C, Schroeder FA, Lin CL, Straubhaar J, Martin G, Akbarian S (2010) Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci 30(21):7152-67. doi : 10.1523/JNEUROSCI.1314-10.2010. PMID: 20505083


Connor C, Cheung I, Simon A, Jakovcevski M, Weng Z, Akbarian S (2010) A simple method for improving the specificity of anti-methyl histone antibodies. Epigenetics 5(5):392-5. Epub 2010 Jul 1. PMID: 20458167 .


Cheung I, Shulha HP, Jiang Y, Matevossian A, Wang J, Weng Z, Akbarian S (2010) Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci U S A. 107(19):8824-9. doi : 10.1073/pnas.1001702107. Epub 2010 Apr 26. PMID: 20421462 .


Jakovcevski M, Guo Y, Su Q, Gao G, Akbarian S (2010) rAAV9–a human-derived adeno -associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harb Protoc 2010(4):pdb.prot5417. doi : 10.1101/pdb.prot5417. PMID: 20360371


Akbarian S (2010) The molecular pathology of schizophrenia–focus on histone and DNA modifications. Brain Res Bull 83(3-4):103-7. doi : 10.1016/j.brainresbull.2009.08.018. Epub 2009 Sep 1. Review. PMID: 19729053 .


Febo M, Akbarian S, Schroeder FA, Ferris CF (2009) Cocaine-induced metabolic activation in cortico -limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate. Neurosci Lett 465(3):267-71. doi : 10.1016/j.neulet.2009.07.065. Epub 2009 Jul 26. PMID: 19638299


Connor CM, Guo Y,  Akbarian S (2009) Cingulate white matter neurons in schizophrenia and bipolar disorder. Biol Psychiatry 66(5):486-93. doi : 10.1016/j.biopsych.2009.04.032. Epub 2009 Jun 25. PMID: 19559403


Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S (2009) Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 65(12):1006-14. doi : 10.1016/j.biopsych.2008.11.019. Epub 2009 Jan 1. PMID: 19121517


Matevossian A, Akbarian S (2008) Neuronal nuclei isolation from human postmortem brain tissue. J Vis Exp (20). pii : 914. doi : 10.3791/914. PMID: 19078943


Matevossian A, Akbarian S (2008) A chromatin assay for human brain tissue. J Vis Exp (13). pii : 717. doi : 10.3791/717. PMID: 19066569 .


Akbarian S (2008) Restoring GABAergic signaling and neuronal synchrony in schizophrenia. Am J Psychiatry 165(12):1507-9. doi : 10.1176/appi.ajp.2008.08081225. No abstract available. PMID: 19047328


Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC (2008) Epigenetics in the nervous system. J Neurosci 28(46):11753-9. doi : 10.1523/JNEUROSCI.3797-08.2008. Review. PMID: 19005036


Akbarian S (2008) Approaching the molecular pathology of suicide. Biol Psychiatry 64(8):643-4. doi : 10.1016/j.biopsych.2008.06.013. No abstract available. PMID: 18926170


Akbarian S , Huang HS (2009) Epigenetic regulation in human brain-focus on histone lysine methylation. Biol Psychiatry 65(3):198-203. doi : 10.1016/j.biopsych.2008.08.015. Epub 2008 Sep 24. Review. PMID: 18814864


Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S (2008) A set of differentially expressed miRNAs , including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 17(19):3030-42. doi : 10.1093/hmg /ddn201. Epub 2008 Jul 15. PMID: 18632683


Jiang Y, Matevossian A, Huang HS, Straubhaar J, Akbarian S (2008) Isolation of neuronal chromatin from brain tissue. BMC Neurosci 9:42. doi : 10.1186/1471-2202-9-42. PMID: 18442397


Connor CM, Akbarian S (2008) DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics 3(2):55-8. Epub 2008 Mar 19. PMID: 18398310


Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR,  Akbarian S (2008) Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology 33(12):2981-92. doi : 10.1038/npp.2008.15. Epub 2008 Feb 20. PMID: 18288092


Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S (2007) Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci 27(42):11254-62. PMID: 17942719


Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S (2007) DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2(9):e895. PMID: 17878930


Huang HS, Akbarian S (2007) GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS One 2(8):e809. PMID: 17726539


Akbarian S , Jiang Y, Laforet G (2006) The molecular pathology of Rett syndrome: synopsis and update. Neuromolecular Med 8(4):485-94. Review. PMID: 17028371


Schroeder FA, Lin CL, Crusio WE, Akbarian S (2007) Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 62(1):55-64. Epub 2006 Aug 30. PMID: 16955350


Akbarian S , Huang HS (2006) Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev 52(2):293-304. Epub 2006 Jun 8. Review. PMID: 16759710 .


Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R, Lu B (2006) NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem 13(3):307-15. Epub 2006 May 16. PMID: 16705139 .


Huang HS, Matevossian A, Jiang Y, Akbarian S (2006) Chromatin immunoprecipitation in postmortem brain. J Neurosci Methods 156(1-2):284-92. Epub 2006 Mar 30. PMID: 16574239


Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK (2006) Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. J Neurobiol 66(4):408-20. PMID: 16408297 .


Akbarian S , Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WE Jr , Conley RC, Jones EG, Tamminga CA, Guo Y (2005) Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry 62(8):829-40. PMID: 16061760


Stadler F, Kolb G, Rubusch L, Baker SP, Jones EG, Akbarian S (2005) Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J Neurochem 94(2):324-36. PMID: 15998284 .


Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C,  Akbarian S (2004) Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J Neurochem 90(5):1117-31. PMID: 15312167 .


Akbarian S (2002) Clinical experts on Rett disorder. Pediatr Rehabil 5(2):117-8. No abstract available. PMID: 12596822


Akbarian S (2003) The neurobiology of Rett syndrome. Neuroscientist 9(1):57-63. Review. PMID: 12580340 .


Tudor M, Akbarian S, Chen RZ, Jaenisch R (2002) Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A. 99(24):15536-41. Epub 2002 Nov 13. PMID: 12432090


Akbarian S (2002) Diseases of the mind and brain: Rett’s syndrome, part II. Am J Psychiatry 159(8) :1294 . No abstract available. PMID: 12153818


Albert KA, Hemmings HC Jr , Adamo AI, Potkin SG,  Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr , Greengard P (2002) Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry 59(8):705-12. PMID: 12150646 .


Akbarian S (2002) Diseases of the mind and brain: Rett’s syndrome. Am J Psychiatry 159(7) :1103 . No abstract available. PMID: 12091185


Akbarian S , Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R (2002) Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 22(10):4153-62. PMID: 12019333


Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA (2002) Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis 9(1):24-37. PMID: 11848682


Akbarian S , Chen RZ, Gribnau J, Rasmussen TP, Fong H, Jaenisch R, Jones EG (2001) Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex. Neurobiol Dis 8(5):784-91. PMID: 11592848 .


Akbarian S , Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK, Jaenisch R (2001) Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Mol Psychiatry 6(5):593-604. PMID: 11526474


Chen RZ, Akbarian S, Tudor M, Jaenisch R (2001) Deficiency of methyl- CpG binding protein-2 in CNS neurons results in a Rett -like phenotype in mice. Nat Genet 27(3):327-31. PMID: 11242118


Akbarian S , Kim JJ, Potkin SG, Hetrick WP, Bunney WE Jr , Jones EG (1996) Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch Gen Psychiatry 53(5):425-36. PMID: 8624186


Akbarian S , Sucher NJ, Bradley D, Tafazzoli A, Trinh D, Hetrick WP, Potkin SG, Sandman CA, Bunney WE Jr , Jones EG (1996) Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. J Neurosci 16(1):19-30. PMID: 8613785 .


Akbarian S , Smith MA, Jones EG (1995) Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer’s disease, Huntington’s disease and schizophrenia. Brain Res 699(2):297-304. PMID: 8616634 .


Akbarian S , Huntsman MM, Kim JJ, Tafazzoli A, Potkin SG, Bunney WE Jr , Jones EG (1995) GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls. Cereb Cortex 5(6):550-60. PMID: 8590827 .


Sucher NJ, Akbarian S, Chi CL, Leclerc CL, Awobuluyi M, Deitcher DL, Wu MK, Yuan JP, Jones EG, Lipton SA (1995) Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J Neurosci 15(10):6509-20. PMID: 7472413


Akbarian S , Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE Jr , Jones EG (1995) Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry 52(4):258-66. PMID: 7702443


Akbarian S , Grüsser OJ, Guldin WO (1994) Corticofugal connections between the cerebral cortex and brainstem vestibular nuclei in the macaque monkey. J Comp Neurol 339(3):421-37. PMID: 7510732


Akbarian S , Grüsser OJ, Guldin WO (1993) Corticofugal projections to the vestibular nuclei in squirrel monkeys: further evidence of multiple cortical vestibular fields. J Comp Neurol 332(1):89-104. PMID: 7685782 .


Akbarian S , Viñuela A, Kim JJ, Potkin SG, Bunney WE Jr , Jones EG (1993) Distorted distribution of nicotinamide -adenine dinucleotide phosphate- diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Arch Gen Psychiatry 50(3):178-87. PMID: 7679892


Akbarian S , Bunney WE Jr , Potkin SG, Wigal SB, Hagman JO, Sandman CA, Jones EG (1993) Altered distribution of nicotinamide -adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry 50(3):169-77. PMID: 7679891


Akbarian S , Grüsser OJ, Guldin WO (1992) Thalamic connections of the vestibular cortical fields in the squirrel monkey (Saimiri sciureus ). J Comp Neurol. 1992 Dec 15 ;326 (3):423-41. PMID: 1469120


Guldin WO, Akbarian S, Grüsser OJ (1992) Cortico -cortical connections and cytoarchitectonics of the primate vestibular cortex: a study in squirrel monkeys (Saimiri sciureus ). J Comp Neurol. 326(3):375-401. PMID: 1281845


Akbarian S , Berndl K, Grüsser OJ, Guldin W, Pause M, Schreiter U (1988) Responses of single neurons in the parietoinsular vestibular cortex of primates. Ann N Y Acad Sci. 545:187-202. PMID: 3149165

Lab Member

Lucy Bicks

Lucy Bicks

Graduate Student

Tristan Fehr

Tristan Fehr

Graduate Student

 Behnam Javidfar

Behnam Javidfar

Lab Technician

Royce Park

Royce Park

Lab Technician

Jennifer Blaze

Jennifer Blaze

Postdoctoral Fellow

Elie Flatow

Elie Flatow

Lab Technician

Bibi Kassim

Bibi Kassim

Lab Technician

Prashanth Rajarajan

Prashanth Rajarajan

MD/PhD Student

Sandhya Chandrasekaran

Sandhya Chandrasekaran

MD/PhD Student

Tobias Halene, MD/PhD

Tobias Halene, MD/PhD

Psychiatry Resident

Elizabeth LaMarca

Elizabeth LaMarca

PhD Student

Jennifer Wiseman

Jennifer Wiseman

Lab Technician

Olivia Devillers

Olivia Devillers

Lab Technician

Yan Jiang, MD/PhD

Yan Jiang, MD/PhD

Assistant Professor

Amanda Mitchell

Amanda Mitchell

Postdoctoral Fellow

Bisrat Woldemichael

Bisrat Woldemichael

Postdoctoral Fellow