Maze Lab

Laboratory of Mechanistic Neuroepigenetics and Disease

Research

ian mazeThe Maze laboratory is focused on understanding the complex interplay between chromatin regulatory mechanisms in brain and neuronal plasticity. We combine a wide variety of biochemical, biophysical, molecular and behavioral approaches to assess the role of histone proteins, and their associated posttranslational modifications, turnover dynamics and remodeling activities, in the regulation of normal neurodevelopment, and the contribution of such processes, or aberrations thereof, to neurological and psychiatric disease. We place particular emphasis on psychiatric disorders associated with monoaminergic (e.g., serotonin, dopamine, etc.) dysfunction, such as major depressive disorder and drug addiction, as well as neurodevelopmental syndromes resulting in deficits in synaptic plasticity and intellectual disability (e.g., Down syndrome and autism). Being both ‘basic’ and translational in nature, our work – so-called “mechanistic neuroepigenetics” – employs state-of-the-art gene and chromatin arraying technologies, analytical chemistry (e.g., mass spectrometry and 14C bomb pulse labeling) and neurobiological phenotyping, in both rodents and humans (postmortem brain and iPSC derived neurons), to explore novel chromatin phenomena in the central nervous system. This includes the identification and characterization of neuronally enriched histone modifications, chromatin “readers,” “writers” and “erasers,” all of which play critical roles in neuronal plasticity and behavioral adaptation.NIMH NID logos

Contact Us

Maze Laboratory
Ian Maze, PhD
Assistant Professor, Neuroscience
Assistant Professor, Pharmacological Sciences
Location
Lab: HESS CSM 9-201
Office: HESS CSM 9-109
Phone
Office: 212.824.8979
Lab: 212.996.7214
Email
Connect with us!
@themazelab

Publications

2018

Zfp189 Mediates Stree Resilience Through a CREB-Regulated Transcriptional Network in Prefrontal Cortex
Lorsh ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Wright WJ, Salery M, Lepack A, Mews P, Issler O, Mckenzie A, Zhou X, Parise LF, Pirpinias ST, Torres IO, Montgomery S, Loh YHE, Labonte B, Conkey A, Symonds AE, Neve R, Turecki G, Maze I, Dong Y, Zhang B, Li S, Bagot RC,Nestler EJ
bioRxiv doi: https://doi.org/10.1101/403733


Chromatin regulation in complex brain disorder
Bastle RM, Maze I
Current Opinion in Behavioral Sciences 2018, 25:57-65


Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
M Heshmati, H Aleyasin, C Menard, DJ Christoffel, ME Flanigan, ML Pfau, …
Proceedings of the National Academy of Sciences 115 (5), 1111-1116 — 2018


Activated Protein C blocks the inhibitory effect on neurite outgrowth by extracellular histones that mediates its inhibition through a retrograde YB-1 signal
MM Siddiq, SS Hannila, Y Zorina, E Nikulina, V Rabinovich, J Hou, R Huq, …
bioRxiv, 365825 — 2018


2017

Macromolecular isolation and purification in AMS
B Buchholz, K Spalding, R Dreier, I Maze, B Mailloux, S Carratt, …
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253 — 2017


2016

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.
Lepack AE, Bagot RC, Peña CJ, Loh YE, Farrelly LA, Lu Y, Powell SK, Lorsch ZS, Issler O, Cates HM, Tamminga CA, Molina H, Shen L, Nestler EJ, Allis CD, Maze I.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12562-12567.


Histone arginine methylation in cocaine action in the nucleus accumbens.
Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ.
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.


Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System.
Farrelly LA, Dill BD, Molina H, Birtwistle MR, Maze I.
Methods Enzymol. 2016;574:331-54. doi: 10.1016/bs.mie.2016.01.013. Epub 2016 Feb 16.


Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.
Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ.
Neuron. 2016 Jun 1;90(5):969-83. doi: 10.1016/j.neuron.2016.04.015. Epub 2016 May 12.


Histone turnover and chromatin accessibility: Critical mediators of neurological development, plasticity, and disease.
Wenderski W, Maze I.
Bioessays. 2016 May;38(5):410-9. doi: 10.1002/bies.201500171. Epub 2016 Mar 15.

2015 & Earlier

ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.
Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Koo JW, Korb E, Bagot RC, Ahn FH, Cahill ME, Labonté B, Mouzon E, Heller EA, Cates H, Golden SA, Gleason K, Russo SJ, Andrews S, Neve R, Kennedy PJ, Maze I, Dietz DM, Allis CD, Turecki G, Varga-Weisz P, Tamminga C, Shen L, Nestler EJ.Nature Medicine. 2015 Oct;21(10):1146-53. doi: 10.1038/nm.3939. Epub 2015 Sep 21.


Critical role of histone turnover in neuronal transcription and plasticity
Maze I, Wenderski W, Noh KM, Bagot R, Tzavaras N, Purushothaman I, Elsässer S, Guo Y, Ionete C, Hurd Y, Tamminga C, Halene T, Farrelly L, Soshnev A, Wen D, Rafii S, Birtwistle M, Akbarian S, Buchholz B, Blitzer R, Nestler E, Yuan ZF, Garcia B, Shen L, Molina H, Allis CD
Neuron. 2015 Jul 1;87(1):77-94. doi: 10.1016/j.neuron.2015.06.014.


Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression.
Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolaños-Guzmán CA, Cheer J, Deisseroth K, Han MH, Nestler EJ.
Nature Communications. 2015 May 8;6:7062. doi: 10.1038/ncomms8062.


Antidepressant action of HDAC inhibition in the prefrontal cortex.
Covington HE 3rd, Maze I, Vialou V, Nestler EJ.
Neuroscience. 2015 Jul 9;298:329-35. doi: 10.1016/j.neuroscience.2015.04.030. Epub 2015 Apr 20.


2014

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Noh KM, Maze I, Zhao D, Xiang B, Wenderski W, Lewis PW, Shen L, Li H, Allis CD.
Proceedings of the National Academy of Sciences. 2015 Jun 2;112(22):6820-7. doi: 10.1073/pnas.1411258112. Epub 2014 Dec 23.


Analytical tools and current challenges in the modern era of neuroepigenomics.
Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ.
Nature Neuroscience. 2014 Nov;17(11):1476-90. doi: 10.1038/nn.3816. Epub 2014 Oct 28. Review.


Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. 
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L.
Genome Biology 2014 April 22; 15(4).


Every amino acid matters: essential contributions of histone variants to mammalian development and disease.
Maze I, Noh KM, Soshnev AA, Allis CD.
Nature Reviews. Genetics 2014 Apr; 15(4).


G9a influences neuronal subtype specification in striatum.
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ.
Nature Neuroscience 2014 Apr; 17(4).


ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes.
Dietz DM, Kennedy PJ, Sun H, Maze I, Gancarz AM, Vialou V, Koo JW, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.
Neuropsychopharmacology 2014 Feb; 39(3).

2013

diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates.
Shen L, Shao NY, Liu X, Maze I, Feng J, Nestler EJ.
PloS one 2013; 8(6).


Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation.
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ.
Nature Neuroscience 2013 Apr; 16(4).


Histone regulation in the CNS: basic principles of epigenetic plasticity.
Maze I, Noh KM, Allis CD.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 2013 Jan; 38(1).

2012

Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens.
Sun H, Maze I, Dietz DM, Scobie KN, Kennedy PJ, Damez-Werno D, Neve RL, Zachariou V, Shen L, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2012 Nov; 32(48).


Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons.
Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ.
Nature Neuroscience 2012 Jun; 15(6).

2011

A role for repressive histone methylation in cocaine-induced vulnerability to stress.
Covington HE, Maze I, Sun H, Bomze HM, DeMaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ.
Neuron 2011 Aug; 71(4).


Behavioral epigenetics.
Lester BM, Tronick E, Nestler E, Abel T, Kosofsky B, Kuzawa CW, Marsit CJ, Maze I, Meaney MJ, Monteggia LM, Reul JM, Skuse DH, Sweatt JD, Wood MA.
Annals of the New York Academy of Sciences 2011 May; 1226.


Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens.
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ.
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb; 108(7).


The epigenetic landscape of addiction.
Maze I, Nestler EJ.
Annals of the New York Academy of Sciences 2011 Jan; 1216.

2010

Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex.
Covington HE, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2010 Dec; 30(48).


Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB.
Vialou V, Maze I, Renthal W, LaPlant QC, Watts EL, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2010 Oct; 30(43).


Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.LaPlant Q, Vialou V, Covington HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ.
Nature Neuroscience 2010 Sep; 13(9).


Transcriptional mechanisms: underlying addiction-related structural plasticity.
Maze I, Russo SJ.
Molecular Interventions 2010 Aug; 10(4).


Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ.
Science (New York, N.Y.) 2010 Jan; 327(5962).

2009

Antidepressant actions of histone deacetylase inhibitors.
Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ, Wu EY, Ghose S, Krishnan V, Russo SJ, Tamminga C, Haggarty SJ, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2009 Sep; 29(37).


Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ.
Neuron 2009 May; 62(3).


Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice.
LaPlant Q, Chakravarty S, Vialou V, Mukherjee S, Koo JW, Kalahasti G, Bradbury KR, Taylor SV, Maze I, Kumar A, Graham A, Birnbaum SG, Krishnan V, Truong HT, Neve RL, Nestler EJ, Russo SJ.
Biological Psychiatry 2009 May; 65(10).


Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.
Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolaños CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2009 Mar; 29(11).

2008

Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure.
Renthal W, Carle TL, Maze I, Covington HE, Truong HT, Alibhai I, Kumar A, Montgomery RL, Olson EN, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2008 Jul; 28(29).


Distinct patterns of DeltaFosB induction in brain by drugs of abuse.
Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ.
Synapse (New York, N.Y.) 2008 May; 62(5).

2007

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Renthal W, Maze I, Krishnan V, Covington HE, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ.
Neuron 2007 Nov; 56(3).


Acute ethanol ingestion produces dose-dependent effects on motor behavior in the honey bee (Apis mellifera).
Maze IS, Wright GA, Mustard JA.
Journal of Insect Physiology; 52(11-12).

Book Chapters

Book Chapters

Wenderski W, Maze I. (2014). Epigenetic mechanisms of drug addiction vulnerability. In J Peedicayil, D Avramopoulos and D Grayson (Eds.), Epigenetics in Psychiatry. Elsevier, New York, p. 441-462.


Maze I, Nestler EJ. (2012), Epigenetics and drug addiction. In Sassone-Corsi P. and Christen Y. (Eds.), Epigenetics, Brain and Behavior. Springer-Verlag, Heidelberg, p. 145-160.


Featured

Ian Maze, Ph.D., 2017 One Mind Rising Star Award winner proposes a potent aim: to determine whether testing the blood for reduced levels of a serotonin-modified protein could help to predict susceptibility to depression under stress, to diagnose major depressive disorder, and/or to predict whether antidepressant medications might help specific patients. Presentation filmed at the 23rd Music Festival for Brain Health, September 16, 2017 Read More

 

Wenderski W, Maze I. (2014). Epigenetic mechanisms of drug addiction vulnerability. In J Peedicayil, D Avramopoulos and D Grayson (Eds.), Epigenetics in Psychiatry. Elsevier, New York, p. 441-462. Read More

 

 

Maze I, Nestler EJ. (2012), Epigenetics and drug addiction. In Sassone-Corsi P. and Christen Y. (Eds.), Epigenetics, Brain and Behavior. Springer-Verlag, Heidelberg, p. 145-160 Read more

 

 

Meet the Team

Lorna Farrelly, Ph.D.

Lorna Farrelly, Ph.D.

Postdoctoral Fellow

lorna.farrelly@mssm.edu
Ryan Bastle, Ph.D.

Ryan Bastle, Ph.D.

Postdoctoral Fellow

ryan.bastle@mssm.edu
Jennifer Chan, Ph.D.

Jennifer Chan, Ph.D.

Postdoctoral Fellow

jennifer.chan2@mssm.edu
Ashley Lepack

Ashley Lepack

PhD Candidate

Ashley.Lepack@icahn.mssm.edu
Amni Al-Kachak

Amni Al-Kachak

PhD Candidate

amni.al-kachak@icahn.mssm.edu
Sasha Fulton

Sasha Fulton

PhD Candidate

sasha.fulton@icahn.mssm.edu
 Andrew Stewart

Andrew Stewart

PhD Student

andrew.stewart@icahn.mssm.edu
Polina Safovich

Polina Safovich

Volunteer

polina.safovich@mssm.edu
Yang Lyu

Yang Lyu

Senior Associate Researcher

yang.lu@mssm.edu

Grants

Active Grants

MQ15FIP100011 (Maze)
MQ: Transforming Mental Health Research Fellowship
Wellcome Trust
Histone monoaminylation in the CNS: novel insights into the cause and treatment of human depression
The major goals of this project are to understand whether serotonergic dysfunction in rodent models of human depression impact the expression of histone serotonylation in brain, as well as if current antidepressants affect such expression.

Alfred P. Sloan Research Fellow in Neuroscience (Maze)
Alfred P. Sloan Foundation
Mechanistic Neuroepigenetics
This is a career award to promote my laboratory’s advancement of the new field of mechanistic
neuroepigenetics.

DP1 DA042078, Avenir Award (Maze)
National Institutes of Health/NIH/DHHS (NIDA)
Roles for histone monoaminylation in cocaine-induced transcriptional and behavioral plasticity
The major goals of this project are to understand whether dopaminergic dysfunction in rodent models of cocaine addiction impact the expression of histone dopaminylation in brain, as well as how such alterations in monoaminylation impact addictive-like phenotypes.

P50 MH096890, Conte Center (Nestler)
National Institutes of Health/NIH/DHHS (NIMH)
Epigenetic mechanisms in depression
The major goals of this project are to continue investigating the “epigenetic” mechanisms underlying human
major depressive disorder, as well as individual responses to antidepressants, using both rodent model systems and human postmortem tissues.
Role: Co-PI (Project 3)

Basil O’Connor Starter Scholar Research Award (Maze)
March of Dimes
Aberrant epigenetic mechanisms contributing to Down syndrome: a novel role for the histone reader
protein BRWD1
The major goals of this project are to characterize the role of BRWD1 and its target genes in mediating intellectual disability in Down syndrome brain.

Fay/Frank Seed Grant (Maze)
Brain Research Foundation
Beyond neurotransmission: exploring roles for synaptic dopaminylation in drug-induced plasticity
The major goals of this project are to use novel chemical approaches to identify synaptic proteins that are dopaminylated in the context of drug abuse (specifically cocaine) for future molecular and behavioral characterizations.

One Mind – Early Diagnostics Rising Star Research Award (Maze)
One Mind Institute
Validation of histone serotonylation as a predictive blood biomarker for stress susceptibility, major
depressive disorder and antidepressant efficacy
The overarching goal of this project is to fully test the hypothesis that newly discovered histone serotonylation may be used as a peripheral biomarker for MDD and/or antidepressant efficacy in human patients in order to aid in the implementation of more effective therapeutic interventions.

R21 DA044767, (Maze/David Shternberg)
National Institutes of Health/NIH/DHHS (NIDA)
Application of intein-based chemical methods to directly manipulate neuronal histone modifications in rodent models of addiction
The major goals of this project are to further develop and implement novel intein-based chemical
methodologies for directly manipulating histone and other protein modifications in vivo in brain, with an extended emphasis on applying these approaches for use in rodent addiction models.

Past Grants

NARSAD Young Investigator Award (Maze)
Brain & Behavior Research Foundation
Epigenomic profile and function of histone variant H3.3 dynamics in depression
The major goal of this project was to investigate the role of histone turnover/H3.3 dynamics in the mediation of
transcriptional abnormalities contributing to depressive-like behaviors in rodent models of human depression.

Rosen Family Research Scholar Award (Maze)
Friedman Brain Institute Pilot Fund Partnership
Function of a novel ‘reader’ of neuronal chromatin in Trisomy 21 associated Alzheimer’s disease
The major goals of this project are to develop a novel hiPSC derived neuronal model of Down syndrome in order
to investigate whether triplication of the neuronally enriched histone reader protein BRWD1 contributes to
observed neurological/synaptic impairments.

T32 MH087004 (Salton)
National Institutes of Health/NIH/DHHS (NIMH)
Genome-wide chromatin accessibility profiling in major depressive disorder reveals astrocytic specific
signatures of reward processing deficits in the orbitofrontal cortex
The major goals of this training grant project are to investigate epigenetic mechanisms underlying human
major depressive disorder, with a specific emphasis on chromatin mediated glial dysfunction leading to
reward processing deficits in the frontal cortex.
Role: Predoctoral Trainee (Fulton)

Active Grants (Lab Members)

F31 DA045428 (Lepack)
National Institutes of Health/NIH/DHHS (NIDA)
Functions for histone dopaminylation in cocaine-induced plasticity
The major goals of this fellowship project are to understand whether dopaminergic dysfunction in rodent
models of cocaine addiction impact the expression of histone dopaminylation in brain, as well as how such
alterations in monoaminylation impact addictive-like phenotypes.

NARSAD Young Investigator Award (Farrelly)
Brain & Behavior Research Foundation
Histone serotonylation: a novel epigenetic mechanism mediating depressive-like phenotypes
The major goals of this young investigator award are to understand whether serotonergic dysfunction in
rodent models of human depression impact the expression of histone serotonylation in brain, as well as if
current antidepressants affect such expression.

T32 DA007135 (Devi)
National Institutes of Health/NIH/DHHS (NIDA)
Role of protein dopaminylation in drug addiction
The major goals of this project are to use novel chemical approaches to identify synaptic proteins that
are dopaminylated in the context of drug abuse (specifically cocaine and heroin) for future molecular
and behavioral characterizations.
Role: Postdoctoral Trainee (Bastle)

Awards

Andrew Stewart: NSF Graduate Research Fellowship. It is awarded based upon an individual’s potential to “contribute to the US science and engineering enterprise.”

Lorna Farrelly: Robin Chemers Neustein Award (The Robin Chemers Neustein Postdoctoral Fellowship award provides an exceptional female, early-career postdoctoral fellow with $25,000 to supplement that postdoctoral fellow’s current stipend/salary for one year.)

Ashley Lepack: 2018 Hausfeld Award (recognizing the most outstanding Neuroscience PhD student at the Icahn School of Medicine at Mount Sinai)

Ashley Lepack: Best Speaker Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2018)

Sasha Fulton: 2018 BRAIN Award (recognizing the most outstanding 2nd year Neuroscience PhD student at the Icahn School of Medicine at Mount Sinai)

Lorna Farrelly: Invited Speaker for the SPiNES Postdoctoral Seminar Series (Neuroscience Institute, New York University School of Medicine)

Lorna Farrelly: Best Poster Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2017)

Lorna Farrelly: 2nd Best Poster Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2016)

Ian Maze: ACNP Travel Award Winner (2015)

Ashley Lepack: Janelia Research Campus Conference Travel Award Winner (2015), “Behavioral Epigenetics: Conserved Mechanisms in Diverse Model Systems