Hof Lab

Laboratory of Neuromorphology


patrick hofOur research is directed towards the study of selective neuronal vulnerability in dementing illnesses using classical neuropathological as well as modern quantitative immunohistochemical methods. We intend to develop a quantitative, detailed and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer disease to other dementing disorders as well as animal models of age-related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations. The regional and laminar distribution in the cerebral cortex of specific neuronal populations is investigated in a variety of neurodegenerative disorders, and quantitatively compared to Alzheimer disease and control brains. In addition, a detailed study of brains from aged patients with no records of neurological and psychiatric disorders is performed in order to define further the limits of normal aging in the brain.

We employ advanced microscopy, high field magnetic resonance imaging, stereologic, and modeling approaches to develop an accurate quantitative assessment of such pathological changes in a region- and layer-specific manner. Neuronal morphology is analyzed in a quantitative manner using intracellular injection of hippocampal and neocortical neurons coupled with computerized reconstruction to assess the degree to which the accumulation of pathologic markers causes dendritic atrophy and spine loss in different subtypes of neocortical pyramidal cells subserving cortical circuits critical for memory and cognition. The characterization of such vulnerable neurons and circuits is fundamental to the design of therapeutic strategies aiming at their protection or rescue. Similar approaches are applied to the neuropathology of autism spectrum disorders, drug-resistant epilepsy, and chronic traumatic encephalopathy.

Finally we are investigating mammalian brain evolution with a focus on cetaceans and great apes. These studies have led us to identify specific neuronal types in parts of the cerebral cortex known to be involved in social awareness, judgment, and attention that can be considered as markers of adaptive mechanisms and functions in response to particular ecological pressure.


Autism BrainNet

Contact Us

Hof Laboratory
Patrick R Hof, MD
Professor, Neuroscience
Professor, Ophthalmology
Professor, Geriatrics and Palliative Medicine
Mount Sinai Center for Discovery and Innovation
787 11th Ave, New York, NY 10019
Lab: W787 Room 800.19-20
Office: W787 Room 833
Office: 332-243-0737
Lab: 332-243-0739


Autism BrainNET

Autism BrainNetAutism BrainNet is a network of academic institutions for the acquisition and distribution of postmortem brain and other tissues to facilitate autism research worldwide. By providing this precious resource for research, Autism BrainNet aims to enhance the understanding, diagnosis and treatment of Autism and related neurodevelopmental disorders, and improve the quality of life of individuals with Autism Spectrum Disorder.

Learn More About Autism BrainNet


The Prenatal Human Brain Atlas

Ding, S.L., Royall, J.J., Lesnar, P., Facer, B.A.C., Smith, K.A., Wei, Y., Brouner, K., Dalley, R.A., Dee, N., Dolbeare, T.A., Ebbert, A., Glass, I.A., Keller, N.H., Lee, F., Lemon, T.A., Nyhus, J., Pendergraft, J., Reid, R., Sarreal, M., Shapovalova, N.V., Szafer, A., Phillips, J.W., Sunkin, S.M., Hohmann, J.G., Jones, A.R., Hawrylycz, M.J., Hof, P.R., Ng, L., Bernard, A., Lein, E.S. (2022) Cellular resolution anatomical and molecular atlases for prenatal human brains. J. Comp. Neurol. 530:6-503, doi: 10.1002/cne.25243.

The Human Brain Atlas

Ding S.L., Royall J.J., Sunkin S.M., Ng L., Facer B.A.C., Lesnar P., Guillozet-Bongaarts A., McMurray B., Szafer A., Dolbeare T.A., Stevens A., Tirrell L., Benner T., Caldejon S., Dalley R.A., Dee N., Lau C., Nyhus J., Reding M., Riley Z.L., Sandman D., Shen E., van der Kouwe A., Varjabedian A., Write M., Zollei L., Dang C., Knowles J.A., Koch C., Phillips J.W., Sestan N., Wohnoutka P., Zielke H.R., Hohmann J.G., Jones A.R., Bernard A., Hawrylycz M.J., Hof P.R., Fischl B., Lein E.S. (2016) Comprehensive cellular-resolution atlas of the adult human brain. J. Comp. Neurol. 524(16):3127-3481, doi:10.1002/cne.24080.

Selected Publications


Costantini, I., Morgan, L., Yang, J., Balbastre, Y., Varadarajan, D., Pesce, L., Scardigli, M., Mazzamuto, G., Gavryusev, V., Castelli, F.M., Roffilli, M., Silvestri, L., Laffey, J., Raia, S., Varghese, M., Wicinski, B., Chang, S., Chen, I.A., Wang, H., Cordero, D., Vera, M., Nolan, J., Nestor, K., Mora, J., Iglesias, J.E., Garcia Pallares, E., Evancic, K., Augustinack, J.C., Fogarty, M., Dalca, A.V., Frosch, M.P., Magnain, C., Frost, R., van der Kouwe, A., Chen, S.C., Boas, D.A., Pavone, F.S., Fischl, B., Hof, P.R. (2023) A cellular resolution atlas of Broca’s area. Sci Adv 9, eadg3844. doi: 10.1126/sciadv.adg3844.

Hawrylycz, M., Martone, M.E., Ascoli, G.A., Bjaalie, J.G., Dong, H.W., Ghosh, S.S., Gillis, J., Hertzano, R., Haynor, D.R., Hof, P.R., Kim, Y., Lein, E., Liu, Y., Miller, J.A., Mitra, P.P., Mukamel, E., Ng, L., Osumi-Sutherland, D., Peng, H., Ray, P.L., Sanchez, R., Regev, A., Ropelewski, A., Scheuermann, R.H., Tan, S.Z.K., Thompson, C.L., Tickle, T., Tilgner, H., Varghese, M., Wester, B., White, O., Zeng, H., Aevermann, B., Allemang, D., Ament, S., Athey, T.L., Baker, C., Baker, K.S., Baker, P.M., Bandrowski, A., Banerjee, S., Bishwakarma, P., Carr, A., Chen, M., Choudhury, R., Cool, J., Creasy, H., D’Orazi, F., Degatano, K., Dichter, B., Ding, S.L., Dolbeare, T., Ecker, J.R., Fang, R., Fillion-Robin, J.C., Fliss, T.P., Gee, J., Gillespie, T., Gouwens, N., Zhang, G.Q., Halchenko, Y.O., Harris, N.L., Herb, B.R., Hintiryan, H., Hood, G., Horvath, S., Huo, B., Jarecka, D., Jiang, S., Khajouei, F., Kiernan, E.A., Kir, H., Kruse, L., Lee, C., Lelieveldt, B., Li, Y., Liu, H., Liu, L., Markuhar, A., Mathews, J., Mathews, K.L., Mezias, C., Miller, M.I., Mollenkopf, T., Mufti, S., Mungall, C.J., Orvis, J., Puchades, M.A., Qu, L., Receveur, J.P., Ren, B., Sjoquist, N., Staats, B., Tward, D., van Velthoven, C.T.J., Wang, Q., Xie, F., Xu, H., Yao, Z., Yun, Z., Zhang, Y.R., Zheng, W.J., Zingg, B. (2023) A guide to the BRAIN Initiative Cell Census Network data ecosystem. PLoS Biol 21, e3002133. doi:10.1371/journal.pbio.3002133. 

Sharma, D.R., Cheng, B., Jaiswal, M.K., Zhang, X., Kumar, A., Parikh, N., Singh, D., Sheth, H., Varghese, M., Dobrenis, K., Zhang, X., Hof, P.R., Stanton, P.K., Ballabh, P. (2023) Elevated insulin growth factor-1 in dentate gyrus induces cognitive deficits in pre-term newborns. Cereb Cortex. doi: 10.1093/cercor/bhac516.

Klaric, T.S., Gudelj, I., Santpere, G., Sousa, A.M.M., Novokmet, M., Vuckovic, F., Ma, S., Beceheli, I., Sherwood, C.C., Ely, J.J., Hof, P.R., Josic, D., Lauc, G., Sestan, N. (2023) Human-specific features and developmental dynamics of the brain N-glycome. bioRxiv. doi: 10.1101/2023.01.11.523525.

Gasperi, R., Gama Sosa, M.A., Perez Garcia, G.S., Perez, G.M., Abutarboush, R., Kawoos, U., Statz, J.K., Patterson, J., Hof, P.R., Katsel, P., Cook, D.G., Ahlers, S.T., Elder, G.A. (2023) Progressive Transcriptional Changes in the Amygdala Implicate Neuroinflammation in the Effects of Repetitive Low-Level Blast Exposure in Male Rats. J Neurotrauma 40, 561-577. doi: 10.1089/neu.2022.0282

Garcia, G.P., Perez, G.M., Gasperi, R., Sosa, M.A.G., Otero-Pagan, A., Abutarboush, R., Kawoos, U., Statz, J.K., Patterson, J., Zhu, C.W., Hof, P.R., Cook, D.G., Ahlers, S.T., Elder, G.A. (2023) (2R,6R)-Hydroxynorketamine Treatment of Rats Exposed to Repetitive Low-Level Blast Injury. Neurotrauma Rep 4, 197-217. doi: 10.1089/neur.2022.0088.

Gama Sosa, M.A., De Gasperi, R., Pryor, D., Perez Garcia, G.S., Perez, G.M., Abutarboush, R., Kawoos, U., Hogg, S., Ache, B., Sowa, A., Tetreault, T., Varghese, M., Cook, D.G., Zhu, C.W., Tappan, S.J., Janssen, W.G.M., Hof, P.R., Ahlers, S.T., Elder, G.A. (2023) Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures. Acta Neuropathol Commun 11, 81. doi: 10.1186/s40478-023-01553-6.

Freire-Cobo, C., Rothwell, E.S., Varghese, M., Edwards, M., Janssen, W.G.M., Lacreuse, A., Hof, P.R. (2023) Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus). Neurobiol Aging 123, 49-62. doi: 10.1016/j.neurobiolaging.2022.12.001.

Edler, M.K., Munger, E.L., Maycon, H., Hopkins, W.D., Hof, P.R., Sherwood, C.C., Raghanti, M.A. (2023) The association of astrogliosis and microglial activation with aging and Alzheimer’s disease pathology in the chimpanzee brain. J Neurosci Res 101, 881-900. doi: 10.1002/jnr.25167.

Alhelo, H., Dogiparthi, J., Baizer, J.S., Hof, P.R., Sherwood, C.C., Kulesza, R. (2023) Characterization of the superior olivary complex of chimpanzees (Pan troglodytes) in comparison to humans. Hear Res 430, 108698. doi: 10.1016/j.heares.2023.108698.


Šimić, G., Krsnik, Ž., Knezović, V., Kelović, Z., Mathiasen, M.L., Junaković, A., Radoš, M., Mulc, D., Španić, E., Quattrocolo, G., Hall, V.J., Zaborszky, L., Vukšić, M., Olucha Bordonau, F., Kostović, I., Witter, M.P., Hof, P.R. (2022) Prenatal development of the human entorhinal cortex. J. Comp. Neurol. 530, 2711-2748. doi: 10.1002/cne.25344.

Ma, S., Skarica, M., Li, Q., Xu, C., Risgaard, R.D., Tebbenkamp, A.T.N., Mato-Blanco, X., Kovner, R., Krsnik, Ž., de Martin, X., Luria, V., Martí-Pérez, X., Liang, D., Karger, A., Schmidt, D.K., Gomez-Sanchez, Z., Qi, C., Gobeske, K.T., Pochareddy, S., Debnath, A., Hottman, C.J., Spurrier, J., Teo, L., Boghdadi, A.G., Homman-Ludiye, J., Ely, J.J., Daadi, E.W., Mi, D., Daadi, M., Marín, O., Hof, P.R., Rasin, M.R., Bourne, J., Sherwood, C.C., Santpere, G., Girgenti, M.J., Strittmatter, S.M., Sousa, A.M.M., Sestan, N. (2022) Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science, eabo7257. doi: 10.1126/science.abo7257.

Munger, E.L., Edler, M.K., Hopkins, W.D., Hof, P.R., Sherwood, C.C., Raghanti, M.A. (2022) Comparative analysis of astrocytes in the prefrontal cortex of primates: Insights into the evolution of human brain energetics. J. Comp. Neurol. doi: 10.1002/cne.25387.


Ackermans, N.L., Varghese, M., Williams, T.M., Grimaldi, N., Selmanovic, E., Alipour, A., Balchandani, P., Reidenberg, J.S., Hof, P.R. (2022) Evidence of traumatic brain injury in headbutting bovids. Acta Neuropathol. 144, 5-26. doi: 10.1007/s00401-022-02427-2.

Pesce, L., Scardigli, M., Gavryusev, V., Laurino, A., Mazzamuto, G., Brady, N., Sancataldo, G., Silvestri, L., Destrieux, C., Hof, P.R., Costantini, I., Pavone, F.S. (2022) 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy. Commun. Biol. 5, 447. doi: 10.1038/s42003-022-03390-0

Pesce, L., Laurino, A., Scardigli, M., Yang, J., Boas, D.A., Hof, P.R., Destrieux, C., Costantini, I., Pavone, F.S. (2022) Exploring the human cerebral cortex using confocal microscopy. Prog. Biophys. Mol. Biol. 168, 3-9. doi: 10.1016/j.pbiomolbio.2021.09.001.

cne.v530.1.coverDing, S.L., Royall, J.J., Lesnar, P., Facer, B.A.C., Smith, K.A., Wei, Y., Brouner, K., Dalley, R.A., Dee, N., Dolbeare, T.A., Ebbert, A., Glass, I.A., Keller, N.H., Lee, F., Lemon, T.A., Nyhus, J., Pendergraft, J., Reid, R., Sarreal, M., Shapovalova, N.V., Szafer, A., Phillips, J.W., Sunkin, S.M., Hohmann, J.G., Jones, A.R., Hawrylycz, M.J., Hof, P.R., Ng, L., Bernard, A., Lein, E.S. (2022) Cellular resolution anatomical and molecular atlases for prenatal human brains. J. Comp. Neurol. 530, 6-503. doi: 10.1002/cne.25243.


Scardigli, M., Pesce, L., Brady, N., Mazzamuto, G., Gavryusev, V., Silvestri, L., Hof, P.R., Destrieux, C., Costantini, I., Pavone, F.S. (2021) Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain Cellular Anatomy Using Advanced Imaging Techniques. Front. Neuroanat. 15, 752234.

Gama Sosa, M.A., De Gasperi, R., Pryor, D., Perez Garcia, G.S., Perez, G.M., Abutarboush, R., Kawoos, U., Hogg, S., Ache, B., Janssen, W.G., Sowa, A., Tetreault, T., Cook, D.G., Tappan, S.J., Gandy, S., Hof, P.R., Ahlers, S.T., Elder, G.A. (2021) Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation. Acta Neuropathol. Commun. 9, 167.

Berg, J., Sorensen, S.A., Ting, J.T., Miller, J.A., Chartrand, T., Buchin, A., Bakken, T.E., Budzillo, A., Dee, N., Ding, S.L., Gouwens, N.W., Hodge, R.D., Kalmbach, B., Lee, C., Lee, B.R., Alfiler, L., Baker, K., Barkan, E., Beller, A., Berry, K., Bertagnolli, D., Bickley, K., Bomben, J., Braun, T., Brouner, K., Casper, T., Chong, P., Crichton, K., Dalley, R., de Frates, R., Desta, T., Lee, S.D., D’Orazi, F., Dotson, N., Egdorf, T., Enstrom, R., Farrell, C., Feng, D., Fong, O., Furdan, S., Galakhova, A.A., Gamlin, C., Gary, A., Glandon, A., Goldy, J., Gorham, M., Goriounova, N.A., Gratiy, S., Graybuck, L., Gu, H., Hadley, K., Hansen, N., Heistek, T.S., Henry, A.M., Heyer, D.B., Hill, D., Hill, C., Hupp, M., Jarsky, T., Kebede, S., Keene, L., Kim, L., Kim, M.H., Kroll, M., Latimer, C., Levi, B.P., Link, K.E., Mallory, M., Mann, R., Marshall, D., Maxwell, M., McGraw, M., McMillen, D., Melief, E., Mertens, E.J., Mezei, L., Mihut, N., Mok, S., Molnar, G., Mukora, A., Ng, L., Ngo, K., Nicovich, P.R., Nyhus, J., Olah, G., Oldre, A., Omstead, V., Ozsvar, A., Park, D., Peng, H., Pham, T., Pom, C.A., Potekhina, L., Rajanbabu, R., Ransford, S., Reid, D., Rimorin, C., Ruiz, A., Sandman, D., Sulc, J., Sunkin, S.M., Szafer, A., Szemenyei, V., Thomsen, E.R., Tieu, M., Torkelson, A., Trinh, J., Tung, H., Wakeman, W., Waleboer, F., Ward, K., Wilbers, R., Williams, G., Yao, Z., Yoon, J.G., Anastassiou, C., Arkhipov, A., Barzo, P., Bernard, A., Cobbs, C., de Witt Hamer, P.C., Ellenbogen, R.G., Esposito, L., Ferreira, M., Gwinn, R.P., Hawrylycz, M.J., Hof, P.R., Idema, S., Jones, A.R., Keene, C.D., Ko, A.L., Murphy, G.J., Ng, L., Ojemann, J.G., Patel, A.P., Phillips, J.W., Silbergeld, D.L., Smith, K., Tasic, B., Yuste, R., Segev, I., de Kock, C.P.J., Mansvelder, H.D., Tamas, G., Zeng, H., Koch, C., Lein, E.S. (2021) Human neocortical expansion involves glutamatergic neuron diversification. Nature 598, 151-158.

Bakken, T.E., Jorstad, N.L., Hu, Q., Lake, B.B., Tian, W., Kalmbach, B.E., Crow, M., Hodge, R.D., Krienen, F.M., Sorensen, S.A., Eggermont, J., Yao, Z., Aevermann, B.D., Aldridge, A.I., Bartlett, A., Bertagnolli, D., Casper, T., Castanon, R.G., Crichton, K., Daigle, T.L., Dalley, R., Dee, N., Dembrow, N., Diep, D., Ding, S.L., Dong, W., Fang, R., Fischer, S., Goldman, M., Goldy, J., Graybuck, L.T., Herb, B.R., Hou, X., Kancherla, J., Kroll, M., Lathia, K., van Lew, B., Li, Y.E., Liu, C.S., Liu, H., Lucero, J.D., Mahurkar, A., McMillen, D., Miller, J.A., Moussa, M., Nery, J.R., Nicovich, P.R., Niu, S.Y., Orvis, J., Osteen, J.K., Owen, S., Palmer, C.R., Pham, T., Plongthongkum, N., Poirion, O., Reed, N.M., Rimorin, C., Rivkin, A., Romanow, W.J., Sedeno-Cortes, A.E., Siletti, K., Somasundaram, S., Sulc, J., Tieu, M., Torkelson, A., Tung, H., Wang, X., Xie, F., Yanny, A.M., Zhang, R., Ament, S.A., Behrens, M.M., Bravo, H.C., Chun, J., Dobin, A., Gillis, J., Hertzano, R., Hof, P.R., Hollt, T., Horwitz, G.D., Keene, C.D., Kharchenko, P.V., Ko, A.L., Lelieveldt, B.P., Luo, C., Mukamel, E.A., Pinto-Duarte, A., Preissl, S., Regev, A., Ren, B., Scheuermann, R.H., Smith, K., Spain, W.J., White, O.R., Koch, C., Hawrylycz, M., Tasic, B., Macosko, E.Z., McCarroll, S.A., Ting, J.T., Zeng, H., Zhang, K., Feng, G., Ecker, J.R., Linnarsson, S., Lein, E.S. (2021) Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature 598, 111-119.

Delpech, J.C., Pathak, D., Varghese, M., Kalavai, S.V., Hays, E.C., Hof, P.R., Johnson, W.E., Ikezu, S., Medalla, M., Luebke, J.I., Ikezu, T. (2021) Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci. Transl. Med. 13, eabe8455.

Ackermans, N.L., Varghese, M., Wicinski, B., Torres, J., De Gasperi, R., Pryor, D., Elder, G.A., Gama Sosa, M.A., Reidenberg, J.S., Williams, T.M., Hof, P.R. (2021) Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy. J. Neurosci. Res. 99, 2463-2477.

Freire-Cobo, C., Edler, M.K., Varghese, M., Munger, E., Laffey, J., Raia, S., In, S.S., Wicinski, B., Medalla, M., Perez, S.E., Mufson, E.J., Erwin, J.M., Guevara, E.E., Sherwood, C.C., Luebke, J.I., Lacreuse, A., Raghanti, M.A., Hof, P.R. (2021) Comparative neuropathology in aging primates: A perspective. Am. J. Primatol. 83, e23299.

Manger, P.R., Patzke, N., Spocter, M.A., Bhagwandin, A., Karlsson, K.A.E., Bertelsen, M.F., Alagaili, A.N., Bennett, N.C., Mohammed, O.B., Herculano-Houzel, S., Hof, P.R., Fuxe, K. (2021) Amplification of potential thermogenetic mechanisms in cetacean brains compared to artiodactyl brains. Sci. Rep. 11, 5486.


Jacot-Descombes, S., Keshav, N.U., Dickstein, D.L., Wicinski, B., Janssen, W.G.M., Hiester, L.L., Sarfo, E.K., Warda, T., Fam, M.M., Harony-Nicolas, H., Buxbaum, J.D., Hof, P.R., Varghese, M. (2020) Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats. Mol. Autism 11, 89.

Kozlenkov, A., Vermunt, M.W., Apontes, P., Li, J., Hao, K., Sherwood, C.C., Hof, P.R., Ely, J.J., Wegner, M., Mukamel, E.A., Creyghton, M.P., Koonin, E.V., Dracheva, S. (2020) Evolution of regulatory signatures in primate cortical neurons at cell-type resolution. Proc. Natl. Acad. Sci. U S A 117, 28422-28432.

Jacot-Descombes, S., Keshav, N., Brosch, C.M.S., Wicinski, B., Warda, T., Norcliffe-Kaufmann, L., Kaufmann, H., Varghese, M., Hof, P.R. (2020) Von Economo Neuron Pathology in Familial Dysautonomia: Quantitative Assessment and Possible Implications. J. Neuropathol. Exp. Neurol. 79, 1072-1083.

Roussarie, J.P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E.F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P.R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O.G., Greengard, P. (2020) Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis. Neuron 107, 821-835 e812.

Sherwood, C.C., Miller, S.B., Karl, M., Stimpson, C.D., Phillips, K.A., Jacobs, B., Hof, P.R., Raghanti, M.A., Smaers, J.B. (2020) Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution. Cereb. Cortex 30, 5604-5615.

Gama Sosa, M.A., De Gasperi, R., Perez, G.M., Hof, P.R., Elder, G.A. (2021) Hemovasculogenic origin of blood vessels in the developing mouse brain. J. Comp. Neurol 529, 340-366.

Nguyen, V.T., Uchida, R., Warling, A., Sloan, L.J., Saviano, M.S., Wicinski, B., Hard, T., Bertelsen, M.F., Stimpson, C.D., Bitterman, K., Schall, M., Hof, P.R., Sherwood, C.C., Manger, P.R., Spocter, M.A., Jacobs, B. (2020) Comparative neocortical neuromorphology in felids: African lion, African leopard, and cheetah. J. Comp. Neurol. 528, 1392-1422.

Wu, T., Chen, C., Spagna, A., Wu, X., Mackie, M.A., Russell-Giller, S., Xu, P., Luo, Y.J., Liu, X., Hof, P.R., Fan, J. (2020) The functional anatomy of cognitive control: A domain-general brain network for uncertainty processing. J. Comp. Neurol. 528, 1265-1292.


Haldipur, P., Aldinger, K.A., Bernardo, S., Deng, M., Timms, A.E., Overman, L.M., Winter, C., Lisgo, S.N., Razavi, F., Silvestri, E., Manganaro, L., Adle-Biassette, H., Guimiot, F., Russo, R., Kidron, D., Hof, P.R., Gerrelli, D., Lindsay, S.J., Dobyns, W. B., Glass, I.A., Alexandre, P., & Millen, K.J. (2019) Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum. Science 366, 454-460.

Pessoa, L., Medina, L., Hof, P.R., & Desfilis, E. (2019) Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition. Neurosci. Biobehav. Rev. 107, 296-312.

Wu, T., Wang, X., Wu, Q., Spagna, A., Yang, J., Yuan, C., Wu, Y., Gao, Z., Hof, P.R., & Fan, J. (2019) Anterior insular cortex is a bottleneck of cognitive control. Neuroimage 195, 490-504.

Tappan, S.J., Eastwood, B.S., O’Connor, N., Wang, Q., Ng, L., Feng, D., Hooks, B.M., Gerfen, C.R., Hof, P.R., Schmitz, C., Glaser, J.R. (2019) Automatic navigation system for the mouse brain. J. Comp. Neurol. 527, 2200-2211.

Gama Sosa, M.A., De Gasperi, R., Perez Garcia, G.S., Perez, G.M., Searcy, C., Vargas, D., Spencer, A., Janssen, P.L., Tschiffely, A.E., McCarron, R.M., Ache, B., Manoharan, R., Janssen, W.G., Tappan, S.J., Hanson, R.W., Gandy, S., Hof, P.R., Ahlers, S.T., Elder, G.A. (2019) Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain. Acta Neuropathol. Commun. 7, 6.

Raghanti, M.A., Wicinski, B., Meierovich, R., Warda, T., Dickstein, D.L., Reidenberg, J.S., Tang, C.Y., George, J.C., Hans Thewissen, J.G.M., Butti, C., Hof, P.R. (2019) A Comparison of the Cortical Structure of the Bowhead Whale (Balaena mysticetus), a Basal Mysticete, with Other Cetaceans. Anat. Rec. (Hoboken) 302, 745-760.

Issa, H.A., Staes, N., Diggs-Galligan, S., Stimpson, C.D., Gendron-Fitzpatrick, A., Taglialatela, J.P., Hof, P.R., Hopkins, W.D., Sherwood, C.C. (2019) Comparison of bonobo and chimpanzee brain microstructure reveals differences in socio-emotional circuits. Brain. Struct. Funct. 224, 239-251.

Miller, M.L., Chadwick, B., Dickstein, D.L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P.R., Roussos, P., Shen, L., Baxter, M.G., Hurd, Y.L. (2019) Adolescent exposure to Delta(9)-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons. Mol. Psychiatry 24, 588-600.

Smith, J.B., Alloway, K.D., Hof, P.R., Orman, R., Reser, D.H., Watakabe, A., Watson, G.D.R. (2019) The relationship between the claustrum and endopiriform nucleus: A perspective towards consensus on cross-species homology. J. Comp. Neurol. 527, 476-499.


Wu T., Dufford A.J., Egan L.J., Mackie M.A., Chen C., Yuan C., Chen C., Li X., Liu X., Hof P.R., Fan J. (2018) Hick-Hyman law is mediated by the cognitive control network in the brain. Cereb. Cortex 28, 2267-2282.

Spagna A., Dufford A.J., Wu Q., Wu T., Zheng W., Coons E.E., Hof P.R., Hu B., Wu Y., Fan J. (2018) Gray matter volume of the anterior insular cortex and social networking. J. Comp. Neurol. 526, 1183-1194.

Jacobs B., Garcia M.E., Shea-Shumsky N.B., Tennison M.E., Schall M., Saviano M.S., Tummino T.A., Bull A.J., Driscoll L.L., Raghanti M.A., Lewandowski A.H., Wicinski B., Ki Chui H., Bertelsen M.F., Walsh T., Bhagwandin A., Spocter M.A., Hof P.R., Sherwood C.C., Manger P.R. (2018) Comparative morphology of gigantopyramidal neurons in primary motor cortex across mammals. J. Comp. Neurol. 526, 496-536.

Raghanti M.A., Edler M.K., Stephenson A.R., Munger E.L., Jacobs B., Hof P.R., Sherwood C.C., Holloway R.L., Lovejoy C.O. (2018) A neurochemical hypothesis for the origin of hominids. Proc. Natl. Acad. Sci. USA. 115, E1108-E1116.

Inquimbert P., Moll M., Latremoliere A., Tong C.K., Whang J., Sheehan G.F., Smith B.M., Korb B., Athié M.C.P., Babaniyi O., Ghasemlou N., Yanagawa Y., Allis C.D., Hof P.R., Scholz J. (2018) NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury. Cell Rep. 23, 2678-2689.

Jazvinscak Jembrek M., Slade N., Hof P.R., Simic G. (2018) The interactions of p53 with tau and Ab as potential therapeutic targets for Alzheimer’s disease. Prog. Neurobiol. 168, 104-127.

Upright N.A., Brookshire S.W., Schebelen W., Damatac C.G., Hof P.R., Browning P.G.F., Croxson P.L., Rudebeck P.H., Baxter M.G. (2018) Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys. J. Neurosci. 38, 7969-7975.

Rutland J.W., Feldman R.E., Delman B.N., Panov F., Fields M.C., Marcuse L.V., Hof P.R., Lin H.M., Balchandani P. (2018) Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla. Seizure 62, 3-10.

Gu, X., Zhou, T.J., Anagnostou, E., Soorya, L., Kolevzon, A., Hof, P.R., and Fan, J. (2018). Heightened brain response to pain anticipation in high-functioning adults with autism spectrum disorder. Eur. J. Neurosci. 47, 592–601.

Tsartsalis, S., Xekardaki, A., Hof, P.R., Kövari, E., and Bouras, C. (2018). Early Alzheimer-type lesions in cognitively normal subjects. Neurobiol. Aging 62, 34–44.

Kiđemet-Piskač, S., Babić Leko, M., Blažeković, A., Langer Horvat, L., Klepac, N., Sonicki, Z., Kolenc, D., Hof, P.R., Boban, M., Mimica, N., et al. (2018). Evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer’s disease and vascular dementia. CNS Neurosci. Ther. 24, 734–740.


Harony-Nicolas H., Kay M., du Hoffmann J., Klein M.E., Bozdagi-Gunal O., Riad M., Daskalakis N.P., Sonar S., Castillo P.E., Hof P.R., Shapiro M.L., Baxter M.G., Wagner S., Buxbaum J.D. (2017) Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. eLife 6, e18904.

Stephenson, A.R., Edler, M.K., Erwin, J.M., Jacobs, B., Hopkins, W.D., Hof, P.R., Sherwood, C.C., and Raghanti, M.A. (2017). Cholinergic innervation of the basal ganglia in humans and other anthropoid primates. J. Comp. Neurol. 525, 319–332.

Simic G., Babic Leko M., Wray S., Harrington C.R., Delalle I., Jovanov-Milosevic N., Bazadona D., Buée L., de Silva R., Di Giovanni G., Wischik C.M., Hof P.R. (2017) Monoaminergic neuropathology in Alzheimer’s disease. Prog. Neurobiol. 151, 101-138.

Li Q., Bozek K., Xu C., Guo Y., Sun J., Pääbo S., Sherwood C.C., Hof P.R., Ely J.J., Li Y., Willmitzer L., Giavalisco P., Khaitovich P. (2017) Changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys. Mol. Biol. Evol.  34, 1155-1166.

Fichtl, A., Büttner, A., Hof, P.R., Schmitz, C., and Kiessling, M.C. (2017). Delineation of Subregions in the Early Postnatal Human Cerebellum for Design-Based Stereologic Studies. Front. Neuroanat. 11, 134.


Ding S.L., Royall J.J., Sunkin S.M., Ng L., Facer B.A.C., Lesnar P., Guillozet-Bongaarts A., McMurray B., Szafer A., Dolbeare T.A., Stevens A., Tirrell L., Benner T., Caldejon S., Dalley R.A., Dee N., Lau C., Nyhus J., Reding M., Riley Z.L., Sandman D., Shen E., van der Kouwe A., Varjabedian A., Write M., Zollei L., Dang C., Knowles J.A., Koch C., Phillips J.W., Sestan N., Wohnoutka P., Zielke H.R., Hohmann J.G., Jones A.R., Bernard A., Hawrylycz M.J., Hof P.R., Fischl B., Lein E.S. (2016) Comprehensive cellular-resolution atlas of the adult human brain. J. Comp. Neurol. 524(16):3127-3481, doi:10.1002/cne.24080.

Babic Leko M., Borovecki F., Dejanovic N., Hof P.R., Simic G. (2016) Predictive value of cerebrospinal fluid visinin-like protein-1 levels for Azheimer’s disease early detection and differential diagnosis in patients with mild cognitive impairment. J. Alzheimer Dis. 50, 765-778.

Perez S.E., Sherwood C.C., Cranfield M.R., Erwin J.M., Mudakikwa A., Hof P.R., Mufson E.J. (2016) Early Alzheimer’s disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol. Aging 39, 195-201.

Stimpson C.D., Barger N., Taglialatella J.P., Gendron-Fitzpatrick A., Hof P.R., Hopkins W.D., Sherwood C.C. (2016) Differential serotonergic innervation of the amygdala of bonobos and chimpanzees. Soc. Cogn. Affect. Neurosci. 11, 413-422.

Jacobs B., Lee L., Schall M., Raghanti M.A., Lewandowski A.H., Kottwitz J.J., Roberts J.F., Hof P.R., Sherwood C.C. (2016) Neocortical neuronal morphology in the newborn giraffe (Giraffa camelopardalis tippelskirchi) and African elephant (Loxodonta africana). J. Comp. Neurol. 524, 257-287.

Raghanti M.A., Edler M.K., Stephenson A.R., Wilson L.J., Hopkins W.D., Ely J.J., Erwin J.M., Jacobs B., Hof P.R., Sherwood C.C. (2016) Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: a comparative analysis of the primate basal ganglia. J. Comp. Neurol. 524, 2217-2129.

Lipovich L., Hou Z.C., Jia H., Sinkler C., McGowen M., Sterner K.N., Weckle A., Sugalski A.B., Pipes L., Gatti D.L., Mason C.E., Sherwood C.C., Hof P.R., Kuzawa C.W., Grossman L.I., Goodman M., Wildman D.E. (2016) High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. J. Comp. Neurol. 524, 288-308.

Xuan B., Mackie M.A., Spagna A., Wu T., Tian Y., Hof P.R., Fan J. (2016) The activation of interactive attentional networks. NeuroImage 129, 308-319.


Wegiel J., Flory M., Kuchna I., Nowicki K., Ma S., Imaki H., Wegiel J., Frackowiak J., Kolecka B., Wierzba-Bobrowicz T., London E., Wisniewski T., Hof P.R., Brown T. (2015) Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults. Acta Neuropathol. Commun. 3, 2.

Bozek K., Wei Y., Yan Z., Liu X., Xiong J., Sugimoto M., Tomita M., Pääbo S., Sherwood C.C., Hof P.R., Ely J.J., Li Y., Steinhauser D., Willmitzer L., Giavalisco P., Khaitovich P. (2015) Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron 85, 695-702.

Barks S.K., Calhoun M.E., Hopkins W.D., Cranfield M.R., Paterson P.E., Mudakikwa A., Erwin J.M., Stoinski T.S., Hecht E.E., Hof P.R., Sherwood C.C. (2015) Brain organization of gorillas reflects species differences in ecological specialization. Am. J. Phys. Anthropol. 156, 252-262.

Coskren P.J., Luebke J.I., Kabaso D., Wearne S.L., Yadav A., Rumbell T., Hof P.R., Weaver C.M. (2015) Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. J. Comput. Neurosci. 38, 263-283.

Luebke J.I., Medalla M., Amatrudo J.M., Weaver C.M., Crimins J.L., Hunt B., Hof P.R., Peters A. (2015) Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb. Cortex 25, 1454-1468.

Uppal N., Puri R., Yuk F., Janssen W.G.M., Bozdagi-Günal O., Harony-Nicolas H., Dickstein D.L., Buxbaum J.D., Hof P.R. (2015) Ultrastructural changes in the CA1 of Shank3-deficient mice. Mol. Autism 6, 41.
Gu X., Eilam-Stock T., Zhou T., Anagnostou E., Kolevzon A., Soorya L., Hof P.R., Friston K.L., Fan J. (2015) Autonomic and brain responses associated with empathy deficits in autism spectrum disorder. Hum. Brain Mapp. 36, 3323-3338.

Raghanti M.A., Spurlock L.B., Treichler F.R., Weigel S.E., Stimmelmayr R., Butti C., Thewissen J.G.M.H., Hof P.R. (2015) An analysis of von Economo neurons in the cerebral cortex of cetaceans, artiodactyls, and perissodactyls. Brain Struct. Funct. 220, 2303-2314.

Bauernfeind A.L., Reyzer M.L., Caprioli R.M., Ely J.J., Babbitt C.C., Wray G.A., Hof P.R., Sherwood C.C. (2015) High spatial resolution proteomic comparison of the brain in humans and chimpanzees. J. Comp. Neurol. 523, 2043-2061.

Brautigam H., Moreno C.L., Steele J.W., Bogush A., Dickstein D.L., Kwok J.B.J., Schofield P.R., Thinakaran G., Mathews P.M., Hof P.R., Gandy S., Ehrlich M.E. (2015) Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Sci. Rep. 5, 17042.


Barks S.K., Bauernfeind A.L., Bonar C.J., Cranfield M.R., de Sousa A.A., Erwin J.M., Hopkins W.D., Lewandowski A.H., Mudakikwa A., Phillips K.A., Raghanti M.A., Stimpson C.D., Hof P.R., Zilles K., Sherwood C.C. (2014) Variable temporoinsular cortex neuroanatomy in primates suggests bottleneck effect in eastern gorillas. J. Comp. Neurol. 522, 844-860.

Eilam-Stock T., Xu P., Cao M., Gu X., Van Dam N.T., Anagnostou E., Kolevzon A., Soorya L., Park Y., Siller M., He Y., Hof P.R., Fan J. (2014) Abnormal autonomic and associated brain activities during rest in autism spectrum disorder. Brain 137, 153-171.

Uppal N., Giannatiempo I., Wicinski B., Schmeidler J., Heinsen H., Schmitz C., Buxbaum J.D., Hof P.R. (2014) Neuropathology of the posteroinferior occipital gyrus in children with autism. Mol. Autism. 5, 17.

Guillozet-Bongaarts A.L., Hyde T.M., Dalley R.A., Hawrylycz M.J., Henry A., Hof P.R., Hohmann J., Jones A.R., Kuan C.L., Royall J., Shen E., Swanson B., Zeng H., Kleinmann J.E. (2014) Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol. Psychiatry 19, 478-485.

Butti C., Fordyce R.E., Raghanti M.A., Gu X., Bonar C.J., Wicinski B.A., Wong E.W., Roman J., Brake A., Eaves E., Spocter M.A., Tang C.Y., Jacobs B., Sherwood C.C., Hof P.R. (2014) The cerebral cortex of the pygmy hippopotamus, Hexaprotodon liberiensis (Cetartiodactyla, Hippopotamidae): MRI, cytoarchitecture, and neuronal morphology. Anat. Rec. 297, 670-700.

Bozek K., Wei Y., Yan Z., Liu X., Xiong J., Sugimoto M., Tomita M., Pääbo S., Pieszek R., Sherwood C.C., Hof P.R., Ely J.J., Steinhauser D., Willmitzer L., Bangsbo J., Hansson O., Call J., Giavalisco P., Khaitovich P. (2014) Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. PLoS Biol. 12(5), e1001871.

Uppal N., Wicinski B., Buxbaum J.D., Heinsen H., Schmitz C., Hof P.R. (2014) Neuropathology of the anterior midcingulate cortex in young children with autism. J. Neuropathol. Exp. Neurol. 73, 891-902.


Van Dam N.T., Sano M., Mitsis E.M., Grossman H.T., Gu X., Park Y., Hof P.R., Fan J. (2013) Functional neural correlates of attentional deficits in amnestic mild cognitive impairment. PLoS One 8(1), e54035.

DeFelipe J., López-Cruz P.L., Benavides-Piccione R., Bielza C., Larrañaga P., Anderson S., Burkhalter A., Cauli B., Fairén A., Feldmeyer D., Fishell G., Fitzpatrick D., Freund T.F., González-Burgos G., Hestrin S., Hill S., Hof P.R., Huang J., Jones E.G., Kawaguchi Y., Kisvarday Z., Kubota Y., Lewis D.A., Marín O., Markram H., McBain C.J., Meyer H.S., Monyer H., Nelson S.B., Rockland K., Rossier J., Rubinstein J.L.R., Rudy B., Scanziani M., Shepherd G.M., Sherwood C.C., Staiger J.F., Tamás G., Thomson A., Wang Y., Yuste R., Ascoli G.A. (2013) New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat. Rev. Neurosci. 14, 202-216.

Höistad M., Heinsen H., Wicinski B., Schmitz C., Hof P.R. (2013) Stereological assessment of the dorsal anterior cingulate cortex in schizophrenia: absence of changes in neuronal and glial densities. Neuropathol. Appl. Neurobiol. 39, 348-361.

Bianchi S., Stimpson C.D., Duka T., Larsen M.D., Janssen W.G.M., Collins Z., Bauernfeind A.L., Schapiro S.J., Baze W.B., McArthur M.J., Hopkins W.D., Wildman D.E., Lipovich L., Kuzawa C.W., Jacobs B., Hof P.R., Sherwood C.C. (2013) Synaptogenesis and development of pyramidal neuron dendritic morphology in the chimpanzee neocortex resembles humans. Proc. Natl. Acad. Sci. USA 110 (Suppl. 2), 10395-10401.

J Comp NeurolGu X, Hof PR, Friston KL, Fan J. Anterior insular cortex and emotional awareness. J Comp Neurol 2013;521:3371-3388.PMID: 23749500

cereb cortex 2013Gu X, Liu X, Van Dam NT, Hof PR, Fan J. Cognition-emotion integration in the anterior insular cortex. Cereb Cortex. 2013;23:20-27. PMID: 22275476


J Neurosci 2012Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. J Neurosci. 2012;32:13644-13660. PMID: 23035077

j comp neurol 2012 520Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, Luebke JI, Hof PR, Weaver CM. Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. J Comp Neurol. 2012;520:2888-2902. PMID: 22315181

nature 2012 489Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489:391-399. PMID: 22996553

cell 2012 149Zeng H, Shen EH, Hohmann JG, Oh SW, Bernard A, Royall JJ, Glattfelder KJ, Sunkin SM, Morris JA, Guillozet-Bongaarts AL, Smith KA, Ebbert AJ, Swanson B, Kuan L, Page DT, Overly CC, Lein ES, Hawrylycz MJ, Hof PR, Hyde TM, Kleinman JE, Jones AR. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell. 2012;149:483-496. PMID: 22500809

Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC. Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci USA. 2012;109:16480-16485. PMID: 23012402

j comp neurol 2012 520Spocter MA, Hopkins WD, Barks SK, Bianchi S, Hehmeyer AE, Anderson SM, Stimpson CD, Fobbs AJ, Hof PR, Sherwood CC. Neuropil distribution in the cerebral cortex differs between humans and chimpanzees. J Comp Neurol. 2012;520:2917-2929. PMID: 22350926

j comp neurol 2012 520Barger N, Stefanacci L, Schumann CM, Sherwood CC, Annese J, Allman JM, Buckwalter JA, Hof PR, Semendeferi K. Neuronal populations in the basolateral nuclei of the amygdala are differentially increased in humans compared with apes: a stereological study. J Comp Neurol. 2012;520:3035-3054. PMID: 22473387

j neuropathol exp neurol 2012 71Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012;71:362-381. PMID: 22487856

acta neuropathol 2012 124Jacot-Descombes S, Uppal N, Wicinski B, Santos M, Schmeidler J, Giannakopoulos P, Heinsen H, Schmitz C, Hof PR. Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism. Acta Neuropathol. 2012;124:67-79. PMID: 22467063

Fan J, Xu P, Van Dam NT, Eilam-Stock T, Gu X, Luo Y, Hof PR. Spontaneous brain activity relates to autonomic arousal. J Neurosci. 2012;32:11176-11186. PMID: 22895703

brain 2012 135Gu X, Gao Z, Wang X, Liu X, Knight RT, Hof PR, Fan J. Anterior insular cortex is necessary for empathetic pain perception. Brain. 2012;135:2726-2735. PMID: 22961548

brain behav 2012 2Fan J, Bernardi S, Dam NT, Anagnostou E, Gu X, Martin L, Park Y, Liu X, Kolevzon A, Soorya L, Grodberg D, Hollander E, Hof PR. Functional deficits of the attentional networks in autism. Brain Behav. 2012;2:647-660. PMID: 2313991

Meet the Team

Bridget A. Wicinski

Laboratory Manager

wicinski bridgetAs lab manager, I am responsible for the daily function of the laboratory. I maintain the microscopes and computers of our quantitative microscopy stations and train students, postdocs, and staff in their proper use. I also train laboratory personnel in a variety of histologic techniques, which allows me to support the experimental work of our ongoing projects. I also catalogue and manage Dr. Hof’s extensive collection of mammalian brain specimens and prepared slides.

Enna Selmanovic

PhD Candidate

Enna SelmanovicEnna graduated from the University of Cincinnati with her degree in Biological Sciences. Post graduation, she lead The Brain Injury Research Center’s Late Effects of Traumatic Brain Injury Project with Dr. Dams-O’Connor. This year she joins Dr. Hof’s lab as a PhD student investigating long term effects of TBI on cognition and post-traumatic neurodegeneration.

Carmen Freire Cobo

Senior Scientist

Carmen Freire CoboMy long term interest has always been the study of synaptic function and dysfunction in normal and pathological states. My scientific training includes multidisciplinary research approaches combining molecular biology, imaging and animal behavior to investigate how synapses undergo functional and structural changes triggered by neural activity. My current work is centered in two main projects using different primate models of human cognitive aging. We investigate the neural substrates of sex and age-related cognitive decline by combining anatomical, physiological and computational approaches, with behavioral assessment of the aging monkey. Our goal is to identify key neurochemical and morphological characteristics underlying age-related brain dysfunction that would serve on the design of therapeutic strategies to reduce cognitive decline during normal aging. 

Merina Varghese

Assistant Professor

merina varghesePathological changes in the brain occurring in neurological and psychiatric diseases drive my research interest. My previous research has uncovered biochemical changes, specifically mitochondrial dysfunction and protein aggregation, occurring in animal and cellular models of various neurodegenerative disorders. I am currently investigating changes in cell morphology, protein expression and pathology in aging, Alzheimer’s disease, and epilepsy using human brain samples obtained postmortem or from surgical resections. 

Former Members

Jacqueline Slobin

Jacqueline Slobin

MD student

Sophia Trapani

Sophia Trapani

Research Volunteer

Jasmine Guo

Jasmine Guo

Research Volunteer

Nicolas Banda

Nicolas Banda

CEYE Student

Cole Jimenez

CEYE Student

Lilly Appiah-Agyeman

Associate Researcher II

Ksenia Orekhova

Ksenia Orekhova

Visiting PhD Candidate

Nicole Ackermans

Nicole Ackermans

Postdoctoral Fellow

Jessie Laffey

Jessie Laffey

Associate Researcher II

Sophia Raia

Sophia Raia

Research Volunteer

Selena Seoyeong In

Selena Seoyeong In

Graduate (MS) Student

Liam Hiester

Liam Hiester

SURP Student

Sarah Jacot-Descombes

Sarah Jacot-Descombes

Postdoctoral Fellow

Edward Sarfo

Edward Sarfo

NERA MedPrep Scholar

Lizette Couto

Lizette Couto

Graduate (MS) Student

Tahia Warda

Tahia Warda

Associate Researcher II

Camilla Butti

Camilla Butti

Visiting Scientist

Marie Kopp

Marie Kopp

Grants Coordinator