The Maze laboratory is focused on understanding the complex interplay between chromatin regulatory mechanisms in brain and neuronal plasticity. We combine a wide variety of biochemical, biophysical, molecular and behavioral approaches to assess the role of histone proteins, and their associated posttranslational modifications, turnover dynamics and remodeling activities, in the regulation of normal neurodevelopment, and the contribution of such processes, or aberrations thereof, to neurological and psychiatric disease. We place particular emphasis on psychiatric disorders associated with monoaminergic (e.g., serotonin, dopamine, etc.) dysfunction, such as major depressive disorder and drug addiction, as well as neurodevelopmental syndromes resulting in deficits in synaptic plasticity and intellectual disability (e.g., Down syndrome and autism). Being both ‘basic’ and translational in nature, our work – so-called “mechanistic neuroepigenetics” – employs state-of-the-art gene and chromatin arraying technologies, analytical chemistry (e.g., mass spectrometry and 14C bomb pulse labeling) and neurobiological phenotyping, in both rodents and humans (postmortem brain and iPSC derived neurons), to explore novel chromatin phenomena in the central nervous system. This includes the identification and characterization of neuronally enriched histone modifications, chromatin “readers,” “writers” and “erasers,” all of which play critical roles in neuronal plasticity and behavioral adaptation.
Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout
Shuai Zhao, Kelly N. Chuh, Baichao Zhang, Barbara E. Dul, Robert E. Thompson, Lorna A. Farrelly, Xiaohui Liu, Ning Xu, Yi Xue, Robert G. Roeder, Ian Maze, Tom W. Muir, and Haitao Li
PNAS. 2021 Feb 9;118(6):e2016742118. doi: 10.1073/pnas.2016742118
Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
Andrew L Eagle, Claire E Manning, Elizabeth S Williams, Ryan M Bastle, Paula A Gajewski, Amber Garrison, Alexis J Wirtz, Seda Akguen, Katie Brandel-Ankrapp, Wilson Endege, Frederick M Boyce, Yoshinori N Ohnishi, Michelle Mazei-Robison, Ian Maze, Rachel L Neve, Alfred J Robison
Nat Commun. 2020 Sep 8;11(1):4484. doi: 10.1038/s41467-020-17825-x.
Nothing Is Yet Set in (Hi)stone: Novel Post-Translational Modifications Regulating Chromatin Function
Jennifer C Chan, Ian Maze
Trends Biochem Sci. 2020 Jun 1. Online ahead of print. DOI: 10.1016/j.tibs.2020.05.009
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.
Ashley E. Lepack, Craig T. Werner, Andrew F. Stewart, Sasha L. Fulton, Ping Zhong, Lorna A. Farrelly, Alexander C. W. Smith, Aarthi Ramakrishnan, Yang Lyu, Ryan M. Bastle, Jennifer A. Martin, Swarup Mitra, Richard M. O’Connor, Zi-Jun Wang, Henrik Molina, Gustavo Turecki, Li Shen, Zhen Yan, Erin S. Calipari, David M. Dietz, Paul J. Kenny and Ian Maze
Science 10 Apr 2020, Vol. 368, Issue 6487, pp. 197-201, DOI: 10.1126/science.aaw8806 | Download reprint
Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving.
Werner CT, Mitra S, Martin JA, Stewart AF, Lepack AE, Ramakrishnan A, Gobira PH, Wang ZJ, Neve RL, Gancarz AM, Shen L, Maze I, Dietz DM.
Sci Adv. 2019 Oct 9;5(10):eaay0351. doi: 10.1126/sciadv.aay0351. eCollection 2019 Oct.
Translational Molecular Approaches in Substance Abuse Research.
Fulton SL, Maze I.
Handb Exp Pharmacol. 2019 Oct 19. doi: 10.1007/164_2019_259.
Epigenetic regulation of hippocampal FosB expression controls behavioral responses to cocaine.
Gajewski PA, Eagle AL, Williams ES, Manning CE, Lynch H, McCornack C, Maze I, Heller EA, Robison AJ.
J Neurosci. 2019 Sep 2. pii: 0800-19.
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, Labonté B, Conkey A, Symonds AE, Neve RL, Turecki G, Maze I, Dong Y, Zhang B, Shen L, Bagot RC, Nestler EJ.
Nat Neurosci. 2019 Sep;22(9):1413-1423
An emerging perspective on ‘histone code’ mediated regulation of neural plasticity and disease.
Farrelly LA, Maze I.
Curr Opin Neurobiol. 2019 Aug 1;59:157-163.
Histone Crotonylation Makes Its Mark in Depression Research.
Chan JC, Maze I.
Biol Psychiatry. 2019 Apr 15;85(8):616-618.
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YHE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW and Maze I
Nature 2019 March doi.org/10.1038/s41586-019-1024-7
Chromatin regulation in complex brain disorder
Bastle RM, Maze I
Current Opinion in Behavioral Sciences 2019, 25:57-65
Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety.
Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW.
Neuropsychopharmacology. 2018 Dec 26. doi: 10.1038/s41386-018-0305-4. [Epub ahead of print]
Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
M Heshmati, H Aleyasin, C Menard, DJ Christoffel, ME Flanigan, ML Pfau, …
Proceedings of the National Academy of Sciences 115 (5), 1111-1116 — 2018
Activated Protein C blocks the inhibitory effect on neurite outgrowth by extracellular histones that mediates its inhibition through a retrograde YB-1 signal
MM Siddiq, SS Hannila, Y Zorina, E Nikulina, V Rabinovich, J Hou, R Huq, …
bioRxiv, 365825 — 2018
Macromolecular isolation and purification in AMS
B Buchholz, K Spalding, R Dreier, I Maze, B Mailloux, S Carratt, …
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253 — 2017
2016 & Earlier
Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.
Lepack AE, Bagot RC, Peña CJ, Loh YE, Farrelly LA, Lu Y, Powell SK, Lorsch ZS, Issler O, Cates HM, Tamminga CA, Molina H, Shen L, Nestler EJ, Allis CD, Maze I.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12562-12567.
Histone arginine methylation in cocaine action in the nucleus accumbens.
Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ.
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.
Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System.
Farrelly LA, Dill BD, Molina H, Birtwistle MR, Maze I.
Methods Enzymol. 2016;574:331-54. doi: 10.1016/bs.mie.2016.01.013. Epub 2016 Feb 16.
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility.
Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ.
Neuron. 2016 Jun 1;90(5):969-83. doi: 10.1016/j.neuron.2016.04.015. Epub 2016 May 12.
Histone turnover and chromatin accessibility: Critical mediators of neurological development, plasticity, and disease.
Wenderski W, Maze I.
Bioessays. 2016 May;38(5):410-9. doi: 10.1002/bies.201500171. Epub 2016 Mar 15.
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.
Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Koo JW, Korb E, Bagot RC, Ahn FH, Cahill ME, Labonté B, Mouzon E, Heller EA, Cates H, Golden SA, Gleason K, Russo SJ, Andrews S, Neve R, Kennedy PJ, Maze I, Dietz DM, Allis CD, Turecki G, Varga-Weisz P, Tamminga C, Shen L, Nestler EJ.Nature Medicine. 2015 Oct;21(10):1146-53. doi: 10.1038/nm.3939. Epub 2015 Sep 21.
Critical role of histone turnover in neuronal transcription and plasticity
Maze I, Wenderski W, Noh KM, Bagot R, Tzavaras N, Purushothaman I, Elsässer S, Guo Y, Ionete C, Hurd Y, Tamminga C, Halene T, Farrelly L, Soshnev A, Wen D, Rafii S, Birtwistle M, Akbarian S, Buchholz B, Blitzer R, Nestler E, Yuan ZF, Garcia B, Shen L, Molina H, Allis CD
Neuron. 2015 Jul 1;87(1):77-94. doi: 10.1016/j.neuron.2015.06.014.
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression.
Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolaños-Guzmán CA, Cheer J, Deisseroth K, Han MH, Nestler EJ.
Nature Communications. 2015 May 8;6:7062. doi: 10.1038/ncomms8062.
Antidepressant action of HDAC inhibition in the prefrontal cortex.
Covington HE 3rd, Maze I, Vialou V, Nestler EJ.
Neuroscience. 2015 Jul 9;298:329-35. doi: 10.1016/j.neuroscience.2015.04.030. Epub 2015 Apr 20.
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Noh KM, Maze I, Zhao D, Xiang B, Wenderski W, Lewis PW, Shen L, Li H, Allis CD.
Proceedings of the National Academy of Sciences. 2015 Jun 2;112(22):6820-7. doi: 10.1073/pnas.1411258112. Epub 2014 Dec 23.
Analytical tools and current challenges in the modern era of neuroepigenomics.
Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ.
Nature Neuroscience. 2014 Nov;17(11):1476-90. doi: 10.1038/nn.3816. Epub 2014 Oct 28. Review.
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L.
Genome Biology 2014 April 22; 15(4).
Every amino acid matters: essential contributions of histone variants to mammalian development and disease.
Maze I, Noh KM, Soshnev AA, Allis CD.
Nature Reviews. Genetics 2014 Apr; 15(4).
G9a influences neuronal subtype specification in striatum.
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ.
Nature Neuroscience 2014 Apr; 17(4).
ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes.
Dietz DM, Kennedy PJ, Sun H, Maze I, Gancarz AM, Vialou V, Koo JW, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.
Neuropsychopharmacology 2014 Feb; 39(3).
diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates.
Shen L, Shao NY, Liu X, Maze I, Feng J, Nestler EJ.
PloS one 2013; 8(6).
Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation.
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ.
Nature Neuroscience 2013 Apr; 16(4).
Histone regulation in the CNS: basic principles of epigenetic plasticity.
Maze I, Noh KM, Allis CD.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 2013 Jan; 38(1).
Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens.
Sun H, Maze I, Dietz DM, Scobie KN, Kennedy PJ, Damez-Werno D, Neve RL, Zachariou V, Shen L, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2012 Nov; 32(48).
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons.
Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ.
Nature Neuroscience 2012 Jun; 15(6).
A role for repressive histone methylation in cocaine-induced vulnerability to stress.
Covington HE, Maze I, Sun H, Bomze HM, DeMaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E, Neve RL, Tamminga CA, Nestler EJ.
Neuron 2011 Aug; 71(4).
Lester BM, Tronick E, Nestler E, Abel T, Kosofsky B, Kuzawa CW, Marsit CJ, Maze I, Meaney MJ, Monteggia LM, Reul JM, Skuse DH, Sweatt JD, Wood MA.
Annals of the New York Academy of Sciences 2011 May; 1226.
Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens.
Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ.
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb; 108(7).
The epigenetic landscape of addiction.
Maze I, Nestler EJ.
Annals of the New York Academy of Sciences 2011 Jan; 1216.
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex.
Covington HE, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2010 Dec; 30(48).
Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB.
Vialou V, Maze I, Renthal W, LaPlant QC, Watts EL, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2010 Oct; 30(43).
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.LaPlant Q, Vialou V, Covington HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ.
Nature Neuroscience 2010 Sep; 13(9).
Transcriptional mechanisms: underlying addiction-related structural plasticity.
Maze I, Russo SJ.
Molecular Interventions 2010 Aug; 10(4).
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ.
Science (New York, N.Y.) 2010 Jan; 327(5962).
Antidepressant actions of histone deacetylase inhibitors.
Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ, Wu EY, Ghose S, Krishnan V, Russo SJ, Tamminga C, Haggarty SJ, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2009 Sep; 29(37).
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ.
Neuron 2009 May; 62(3).
Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice.
LaPlant Q, Chakravarty S, Vialou V, Mukherjee S, Koo JW, Kalahasti G, Bradbury KR, Taylor SV, Maze I, Kumar A, Graham A, Birnbaum SG, Krishnan V, Truong HT, Neve RL, Nestler EJ, Russo SJ.
Biological Psychiatry 2009 May; 65(10).
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.
Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolaños CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2009 Mar; 29(11).
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure.
Renthal W, Carle TL, Maze I, Covington HE, Truong HT, Alibhai I, Kumar A, Montgomery RL, Olson EN, Nestler EJ.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 2008 Jul; 28(29).
Distinct patterns of DeltaFosB induction in brain by drugs of abuse.
Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ.
Synapse (New York, N.Y.) 2008 May; 62(5).
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Renthal W, Maze I, Krishnan V, Covington HE, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ.
Neuron 2007 Nov; 56(3).
Acute ethanol ingestion produces dose-dependent effects on motor behavior in the honey bee (Apis mellifera).
Maze IS, Wright GA, Mustard JA.
Journal of Insect Physiology; 52(11-12).
Wenderski W, Maze I. (2014). Epigenetic mechanisms of drug addiction vulnerability. In J Peedicayil, D Avramopoulos and D Grayson (Eds.), Epigenetics in Psychiatry. Elsevier, New York, p. 441-462.
Maze I, Nestler EJ. (2012), Epigenetics and drug addiction. In Sassone-Corsi P. and Christen Y. (Eds.), Epigenetics, Brain and Behavior. Springer-Verlag, Heidelberg, p. 145-160.
Ian Maze, Ph.D., 2019 Winner of Presidential Early Career Award for Scientists and Engineers (PECASE). Established in 1996, The PECASE is the highest honor bestowed by the United States Government to outstanding scientists and engineers who are beginning their independent research careers and who show exceptional promise for leadership in science and technology.
Ian Maze, Ph.D., 2017 One Mind Rising Star Award winner proposes a potent aim: to determine whether testing the blood for reduced levels of a serotonin-modified protein could help to predict susceptibility to depression under stress, to diagnose major depressive disorder, and/or to predict whether antidepressant medications might help specific patients. Presentation filmed at the 23rd Music Festival for Brain Health, September 16, 2017 Read More
Meet the Team
Sohini Dutta, Ph.D.
Previous Lab Members
Lorna Farrelly, Ph.D.
Scientist at Regeneron
Ryan Bastle, Ph.D.
Medical Science Liaison at AbbVie
Medical Scribe at CityMD
Senior Associate Researcher
R01 MH116900, (Maze)
National Institutes of Health/NIH/DHHS (NIMH)
Molecular studies of neural histone monoaminylation in normal and aberrant brain plasticity
The major goals of this project are to investigate cell-type, brain region and sex specific roles for histone monoaminylation in the precipitation of depressive-like behaviors and antidepressant actions in rodent models of major depressive disorder.
R01 HD097088 (Maze)
National Institutes of Health/NIH/DHHS (NICHD)
Aberrant chromatin regulatory mechanisms in Down syndrome brain
The major goals of this project are to investigate potential roles for the chromatin “reader” protein BRWD1 in Down syndrome associated neurological and cognitive deficits, and more broadly to examine epigenetic dysregulation in Trisomy 21
DP1 DA042078, Avenir Award (Maze)
National Institutes of Health/NIH/DHHS (NIDA)
Roles for histone monoaminylation in cocaine-induced transcriptional and behavioral plasticity
The major goals of this project are to understand whether dopaminergic dysfunction in rodent models of cocaine addiction impact the expression of histone dopaminylation in brain, as well as how such alterations in monoaminylation impact addictive-like phenotypes.
P50 MH096890, Conte Center (Nestler)
National Institutes of Health/NIH/DHHS (NIMH)
Epigenetic mechanisms in depression
The major goals of this project are to continue investigating the “epigenetic” mechanisms underlying human
major depressive disorder, as well as individual responses to antidepressants, using both rodent model systems and human postmortem tissues.
Role: Co-PI (Project 3)
One Mind – Early Diagnostics Rising Star Research Award (Maze)
One Mind Institute
Validation of histone serotonylation as a predictive blood biomarker for stress susceptibility, major
depressive disorder and antidepressant efficacy
The overarching goal of this project is to fully test the hypothesis that newly discovered histone serotonylation may be used as a peripheral biomarker for MDD and/or antidepressant efficacy in human patients in order to aid in the implementation of more effective therapeutic interventions.
R21 DA044767, (Maze/David Shternberg)
National Institutes of Health/NIH/DHHS (NIDA)
Application of intein-based chemical methods to directly manipulate neuronal histone modifications in rodent models of addiction
The major goals of this project are to further develop and implement novel intein-based chemical
methodologies for directly manipulating histone and other protein modifications in vivo in brain, with an extended emphasis on applying these approaches for use in rodent addiction models.
Basil O’Connor Starter Scholar Research Award (Maze)
March of Dimes
Aberrant epigenetic mechanisms contributing to Down syndrome: a novel role for the histone reader
The major goals of this project are to characterize the role of BRWD1 and its target genes in mediating intellectual disability in Down syndrome brain.
Alfred P. Sloan Research Fellow in Neuroscience (Maze)
Alfred P. Sloan Foundation
This is a career award to promote my laboratory’s advancement of the new field of mechanistic
MQ: Transforming Mental Health Research Fellowship
Histone monoaminylation in the CNS: novel insights into the cause and treatment of human depression
The major goals of this project are to understand whether serotonergic dysfunction in rodent models of human depression impact the expression of histone serotonylation in brain, as well as if current antidepressants affect such expression.
Fay/Frank Seed Grant (Maze)
Brain Research Foundation
Beyond neurotransmission: exploring roles for synaptic dopaminylation in drug-induced plasticity
The major goals of this project are to use novel chemical approaches to identify synaptic proteins that are dopaminylated in the context of drug abuse (specifically cocaine) for future molecular and behavioral characterizations.
NARSAD Young Investigator Award (Maze)
Brain & Behavior Research Foundation
Epigenomic profile and function of histone variant H3.3 dynamics in depression
The major goal of this project was to investigate the role of histone turnover/H3.3 dynamics in the mediation of
transcriptional abnormalities contributing to depressive-like behaviors in rodent models of human depression.
Rosen Family Research Scholar Award (Maze)
Friedman Brain Institute Pilot Fund Partnership
Function of a novel ‘reader’ of neuronal chromatin in Trisomy 21 associated Alzheimer’s disease
The major goals of this project are to develop a novel hiPSC derived neuronal model of Down syndrome in order
to investigate whether triplication of the neuronally enriched histone reader protein BRWD1 contributes to
observed neurological/synaptic impairments.
Active Grants (Lab Members)
F31 MH124425 (Fulton)
National Institutes of Health (NIMH)
Investigating Chromatin-Based Mechanisms Of Astrocyte Pathology During Inflammation Response And Stress-Induced Behaviors
NSF Graduate Research Fellowship (Stewart)
National Science Foundation/GRFP
It is awarded based upon an individual’s potential to “contribute to the US science and engineering enterprise.”
Past Grants (Lab Members)
K99 MH120334 01 (Farrelly)
National Institutes of Health/RTCD (NIMH)
Studies of histone serotonylation and its role in transcriptional and neural plasticity
F31 DA045428 (Lepack)
National Institutes of Health/NIH/DHHS (NIDA)
Functions for histone dopaminylation in cocaine-induced plasticity
The major goals of this fellowship project are to understand whether dopaminergic dysfunction in rodent
models of cocaine addiction impact the expression of histone dopaminylation in brain, as well as how such
alterations in monoaminylation impact addictive-like phenotypes.
NARSAD Young Investigator Award (Farrelly)
Brain & Behavior Research Foundation
Histone serotonylation: a novel epigenetic mechanism mediating depressive-like phenotypes
The major goals of this young investigator award are to understand whether serotonergic dysfunction in
rodent models of human depression impact the expression of histone serotonylation in brain, as well as if
current antidepressants affect such expression.
T32 DA007135 (Devi)
National Institutes of Health/NIH/DHHS (NIDA)
Role of protein dopaminylation in drug addiction
The major goals of this project are to use novel chemical approaches to identify synaptic proteins that
are dopaminylated in the context of drug abuse (specifically cocaine and heroin) for future molecular
and behavioral characterizations.
Role: Postdoctoral Trainee (Bastle)
T32 MH087004 (Salton)
National Institutes of Health/NIH/DHHS (NIMH)
Genome-wide chromatin accessibility profiling in major depressive disorder reveals astrocytic specific
signatures of reward processing deficits in the orbitofrontal cortex
The major goals of this training grant project are to investigate epigenetic mechanisms underlying human
major depressive disorder, with a specific emphasis on chromatin mediated glial dysfunction leading to
reward processing deficits in the frontal cortex.
Role: Predoctoral Trainee (Fulton)
Ashley Lepack: 2020 Winner of the Nemko Prize in Cellular and Molecular Neuroscience
Ian Maze: 2019 Winner of Presidential Early Career Award for Scientists and Engineers (PECASE)
Ian Maze: 2019 Dr. Harold and Golden Laport Basic Research Award
Lorna Farrelly: The Friedman Brain Institute 2019 POSTDOC Award: for the best record of achievement in neuroscience.
Amni Al-Kachak: The Friedman Brain Institute 2019 Best Graduate Student Poster Award
Lorna Farrelly: Robin Chemers Neustein Award (The Robin Chemers Neustein Postdoctoral Fellowship award provides an exceptional female, early-career postdoctoral fellow with $25,000 to supplement that postdoctoral fellow’s current stipend/salary for one year.)
Ashley Lepack: 2018 Hausfeld Award (recognizing the most outstanding Neuroscience PhD student at the Icahn School of Medicine at Mount Sinai)
Ashley Lepack: Best Speaker Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2018)
Sasha Fulton: 2018 BRAIN Award (recognizing the most outstanding 2nd year Neuroscience PhD student at the Icahn School of Medicine at Mount Sinai)
Lorna Farrelly: Invited Speaker for the SPiNES Postdoctoral Seminar Series (Neuroscience Institute, New York University School of Medicine)
Lorna Farrelly: Best Poster Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2017)
Lorna Farrelly: 2nd Best Poster Prize, Icahn School of Medicine at Mount Sinai’s Annual Neuroscience Retreat (2016)
Ian Maze: ACNP Travel Award Winner (2015)
Ashley Lepack: Janelia Research Campus Conference Travel Award Winner (2015), “Behavioral Epigenetics: Conserved Mechanisms in Diverse Model Systems