Salton Lab - Molecular Neurobiology of Neurotrophin & Neuropeptide Signaling

Research

stephen salton md phdOur lab is interested in understanding how neurotrophic growth factors, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), regulate nervous system development and function. We study neurotrophin action through the identification of gene products that these growth factors regulate in the CNS and PNS, determining how these proteins are involved in neurogenesis, axonal outgrowth and pathfinding, synaptogenesis, and synaptic plasticity, using cellular and molecular tools, and knockout mouse models. Together with the Benson lab, we’re currently examining how the NGF-regulated cell surface adhesion protein, called NILEGP or L1, an immunoglobulin (Ig) superfamily member that is expressed primarily in the nervous system, regulates axonal outgrowth, branching, pathfinding, and fasciculation, as well as neuronal migration. Of note, inherited X-linked mutations in L1 result in hydrocephalus and mental retardation (CRASH and MASA syndromes). In addition, we’re trying to understand how the neurotrophin-inducible gene Vgf, encoding a secreted ‘granin-like’ protein and peptide precursor, controls energy expenditure, memory, and depressive behavior. Recent collaborative studies with the Huntley, Alberini, Shapiro, and Duman laboratories indicate that VGF-derived peptides injected into the brain have anti-depressant efficacy, consistent with abnormalities noted in memory tasks and depressed behavior in VGF knockout mice, and that VGF regulates hippocampal synaptic activity via a BDNF-dependent mechanism. We are developing novel conditional and humanized knockout models to better understand VGF function in the developing and adult hippocampus, hypothalamus, and sympathetic nervous system.

Contact Us

Salton Laboratory
Stephen Salton, MD, PhD
Professor, Neuroscience
Professor, Geriatrics and Palliative Medicine
Location
Lab: CSM9-301-SL
Office: CSM9-110
Phone
Office: 212.824.9308
Lab: 212.824.9117
Email

Featured

Featured Publication

Beckmann N.D.*, Lin W.J.*, Wang M.*, Cohain A.T., Charney A.W., Wang P., Ma W., Wang Y.C., Jiang C., Audrain M., Comella P.H., Fakira A.K., Hariharan S.P., Belbin G.M., Girdhar K., Levey A.I., Seyfried N.T., Dammer E.B., Duong D., Lah J.J., Haure-Mirande J.V., Shackleton B., Fanutza T., Blitzer R., Kenny E., Zhu J., Haroutunian V., Katsel P., Gandy S., Tu Z., Ehrlich M.E., Zhang B., Salton, S.R.@, Schadt, E.@ (2020).  Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease.  * equal contribution; @ corresponding authors.  Nat Commun 11:3942.  Highlighted in Editors’ Highlights webpage, ‘From Brain to Behavior’.
Detailed ‘big data’ predictive analyses and functional studies show that the VGF protein protects against onset and progression of Alzheimer’s disease, paving the way for future drug discovery efforts.

Meet the Team

Gabriela Farias Quipildor, Ph.D

Gabriela Farias Quipildor, Ph.D

Postdoctoral Fellow

Rajeev

Rajeev

M.S. Student

Allen Liang Pan, PhD

Allen Liang Pan, PhD

Postdoctoral Fellow

Dipa Meenakshi Bose

Dipa Meenakshi Bose

M.S. Student

Bhavita Walia, Ph.D

Postdoctoral Fellow

Recent Salton Lab Alumni

Valeria Cogliani

Valeria Cogliani

Research Coordinator

masato.sadahiro@mssm.edu

Samira Fargali

Samira Fargali

Postdoctoral Fellow

samira.fargali@mssm.edu

Jay (WeiJye) Lin

Jay (WeiJye) Lin

Postdoctoral Fellow

weijye.lin@mssm.edu

Tricia Indall

Tricia Indall

Masters Student

tricia.indall@mssm.edu

Masato Sadahiro

Masato Sadahiro

Masters Student

masato.sadahiro@mssm.edu