Research
In our daily lives we often encounter both pleasurable and aversive situations, which heighten our emotional state and affect cognition. The ability to flexibly regulate our emotions in response to such events is essential for adapting to our environment and, ultimately, for our mental health. Many forms of mental illness involve dysfunction in the neural systems that regulate affective processing and decision making. The limbic system, which includes parts of the prefrontal cortex and medial temporal lobe, is critical for regulating emotions and plays an essential role in cognition. The main focus of the Rudebeck lab is to understand how interaction between the prefrontal cortex and subcortical structures such as the amygdala contribute to emotional regulation and decision-making. To do this, we use a combination of behavioral, autonomic, neurophysiological and interference methods in animal models.
Rudebeck Laboratory
Peter H Rudebeck, PhD
Associate Professor, Neuroscience
Associate Professor, Psychiatry
Location
Lab: HESS CSM 10-203A
Office: HESS CSM 10-112
Phone
Office: 212.824.9307
Lab: 212.824.9184
Email: peter.rudebeck@mssm.edu
Featured
Publications
In press / BioRxiv
Atsushi Fujimoto, Catherine Elorette, Satoka Hashimoto Fujimoto, Lazar Fleysher, Brian E Russ & Peter H Rudebeck (2024) Ventrolateral prefrontal cortex in macaques guides decisions in different learning contexts, bioRxiv, under review
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Satoka H. Fujimoto, Atsushi Fujimoto, Catherine Elorette, Adela Seltzer, Emma Andraka, Gaurav Verma, William GM Janssen, Lazar Fleysher, Davide Folloni, Ki Sueng Choi, Brian E. Russ+, Helen S. Mayberg+, Peter H. Rudebeck+(2024) Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks, under review, bioRxiv
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Davide Folloni, Lea Roumazeilles, Katherine L Bryant, Paul R Manger, Mads F Bertelsen, Alexandre A Khrapitchev, Peter H Rudebeck, Rogier B Mars (2024) Comparing the limbic-frontal connectome across the primate order: conservation of connections and implications for translational neuroscience. bioRxiv, under review
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Atsushi Fujimoto, Catherine Elorette, Satoka Hashimoto Fujimoto, Lazar Fleysher, Peter H Rudebeck, Brian E Russ Pharmacological modulation of dopamine D1 and D2 receptors reveals distinct neural networks related to probabilistic learning in non-human primates. bioRxiv in revision
Matthew G. Perich, Charlotte Arlt, Sofia Soares, Megan E. Young, Clayton P. Mosher, Juri Minxha, Eugene Carter, Ueli Rutishauser, Peter H. Rudebeck, Christopher D. Harvey, Kanaka Rajan (2020) Inferring brain-wide interactions using data-constrained recurrent neural network models. BioRxiv
Frederic M. Stoll, Clayton P. Mosher, Sarita Tamang, Elisabeth A. Murray, and Peter H. Rudebeck (2017) Amygdala plays distinct roles on prefrontal local field potential and single neuron encoding of reward-based decisions. bioRxiv
Jamie Nagy, Mark G. Baxter, Christienne Damatac, Peter H. Rudebeck, and Paula L. Croxson (2017) Lack of sex differences in higher cognitive function in macaques. bioRxiv
2024
Frederic M. Stoll and Peter H Rudebeck (2024) Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex. Current Biology, online 9/17/2024 bioRxiv
Satoka Hashimoto Fujimoto, Atsushi Fujimoto, Catherine Elorette, Ki Sueng Choi, Helen S. Mayberg, Brian E Russ Peter H Rudebeck (2024) What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry? Neuropsychopharmacology, online ahead of print
Frederic M. Stoll and Peter H Rudebeck (2024) Dissociable representations of decision variables within subdivisions of macaque orbitofrontal and ventrolateral frontal cortex. Journal of Neuroscience, 44(35), e0464242024, bioRxiv
Zachary R Zeisler, Kelsey A Heslin, Frederic M Stoll, Patrick R Hof, Roger L Clem, and Peter H Rudebeck (2024) Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice. Current Biology, 34(14):3249-3257.e3 bioRxiv
Praveen Suthaharan, Summer L. Thompson, Rosa A. Rossi-Goldthorpe, Peter H. Rudebeck, Mark E. Walton, Subhojit Chakraborty, Maryann P. Noonan, Anna S. Mitchell, Vincent D. Costa, Elisabeth A. Murray, Christoph D. Mathys, Stephanie M. Groman, Jane R. Taylor, Philip R. Corlett+, Steve W.C. Chang+ (2023) Lesions to the mediodorsal thalamus but not orbitofrontal cortex enhance volatility beliefs linked to paranoia. Cell Reports, 43(6):114355 PsyArxiv
Catherine Elorette*, Atsushi Fujimoto*, Frederic M. Stoll, Satoka H. Fujimoto, Niranjana Bienkowska, Liza London, Lazar Fleysher, Brian E. Russ+, and Peter H. Rudebeck+ (2023) The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation. Nature Communications, 15(1):4669 bioRxiv
Frederic M. Stoll and Peter H. Rudebeck (2024) Preferences reveal separable valuation systems in prefrontal-limbic circuits. Neuron, 112(13):2241-2256.e8 bioRxiv
2023
Zachary R Zeisler, Liza London, William G Janssen, J Megan Fredericks, Catherine Elorette, Atsushi Fujimoto, Huiqing Zhan, Brian E Russ, Roger L Clem, Patrick R Hof, Frederic M Stoll, and Peter H Rudebeck (2022) High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex. Neuron, in press
Megan E. Young*, Camille Spencer-Salmon*, Clayton Mosher, Sarita Tamang, Kanaka Rajan, and Peter H. Rudebeck (2023) Temporally-specific sequences of neural activity in interconnected corticolimbic structures during reward anticipation. Neuron, doi: 10.1016/j.neuron.2023.07.012
2022
Peter H. Rudebeck and Alicia Izquierdo (2022) Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior. Neuropsychopharmacology, 47(1):134-146
Atsushi Fujimoto*, Catherine Elorette*, J. Megan Fredericks, Satoka H. Fujimoto, Lazar Fleysher, Peter H. Rudebeck+, and Brian E. Russ+ (2022) Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects. Journal of Neuroscience, 42(29):5705-5716
2020-2021
Eliza Bliss-Moreau and Peter H. Rudebeck (2020) Animal Models of Human Mood. Neuroscience Biobehavioral Reviews, (20) 30451-6
Catherine Elorette, Atsushi Fujimoto, J. Megan Fredericks, Frederic M. Stoll, Brian E. Russ, and Peter H. Rudebeck (2021) Piecing together the orbitofrontal puzzle. Behavioral Neuroscience, 135(2):301-311
Atsushi Fujimoto, Elisabeth A. Murray, and Peter H. Rudebeck (2021) Interaction between decision-making and interoceptive representations of arousal in frontal cortex. Proceedings of the National Academy of the Sciences USA, 118(35): e2014781118
Kevin Norman, Hiroyuki Koike, Julia Bateh, Sarah Lopez, Keaven Caro, Daisuke Kato, Kazuhiko Yamamuro, Meghan Flanigan, Yury Garkun, Elisa Nabel, Daniel Brady, Christina Cho, Justin Riceberg, Masato Sadahiro, Michael Demars, Matthew Shapiro, Scott Russo, Mark Baxter, Peter Rudebeck, Hirofumi Morishita (2021) Post-error Recruitment of Frontal-sensory Cortical Projection Promotes Attentional Behavior. Neuron, 109(7):1202-1213
Joseph Simon IV, Peter H Rudebeck, Erin L. Rich (2021) From affective to cognitive processing: Functional organization of the medial frontal cortex. International Review of Neurobiology, 158:1-28
2019
Danielle Beckman, Kristine Donis-Cox, Sean Ott, Mary Roberts, Lisa Novik, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison (2019) Quantitative analysis of synaptic pathology and neuroinflammation: an initial study in a female rhesus monkey model of the synaptic phase of Alzheimer′s Disease. Proceedings of the National Academy of Sciences of the USA, doi: 10.1073/pnas.1902301116
Peter H. Rudebeck, Erin L. Rich, Helen S. Mayberg (2019) From bed to bench side: reverse translation for mood disorders neuromodulation therapies. Proceedings of the National Academy of Sciences of the USA, doi: 10.1073/pnas.1902287116
Frederic M. Stoll and Peter H. Rudebeck (2019) The value of persistent value. Neuron, 103(5):757-758
Megan Fredericks, Atsushi Fujimoto, and Peter H. Rudebeck (2019) Trust, but verify: a cautionary tale of translating chemogenetics. European Journal of Neuroscience. 50(5):2751-2754
Maia S. Pujara, Peter H. Rudebeck, Nicole K. Ciesinski, and Elisabeth A. Murray (2018) Heightened defensive responses following subtotal lesions of macaque orbitofrontal cortex. Journal of Neuroscience, 39 (21) 4133-414
2018
Peter H. Rudebeck and Erin L. Rich (2018) Primer on OFC. Current Biology, 28(18):R1083-R1088
James J Young, Peter H Rudebeck, Lara V Marcuse, Madeline C Fields, Ji Yeoun Yoo, Fedor Panov, Saadi Ghatan, Arash Fazl, Sarah Mandelbaum, Mark G Baxter (2018) A Theta Band Network Involving Prefrontal Cortex Unique to Human Episodic Memory. Neuroimage, 183:565-573
Nicholas Upright, Stephen Brookshire, Wendy Schnebelen, Christienne Damatac, Patrick Hof, Philip G. Browning, Paula L. Croxson, Peter H. Rudebeck, and Mark G. Baxter (2018) Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys. Journal of Neuroscience, 38(37):7969-7975
Elisabeth A. Murray and Peter H. Rudebeck (2018) Specializations for value-based decision making in the primate ventral prefrontal cortex. Nature Reviews Neuroscience, 19(7): 404-417
Erin L. Rich, Frederic M. Stoll, and Peter H. Rudebeck (2018) Linking dynamic patterns of neural activity in orbitofrontal cortex with decision making. Current Opinion in Neurobiology. 49:24-32 (https://authors.elsevier.com/a/1WMdV3Q9h1uvLz)
2017
Peter H. Rudebeck, Richard C. Saunders, Dawn A. Lundgren, and Elisabeth A. Murray (2017) Specialized representations of value in orbital and ventrolateral prefrontal cortex: desirability versus availability of outcomes. Neuron, 95(5): 1208-1220
Peter H. Rudebeck, Joshua A. Ripple, Andrew R. Mitz, Bruno B. Averbeck, and Elisabeth A. Murray (2017) Amygdala contributions to stimulus–reward encoding in the macaque medial and orbital frontal cortex during learning. Journal of Neuroscience, 37(8): 2186-2202
Andrew R. Mitz, Ravi V. Chako, Philip T. Putnam, Peter H. Rudebeck, and Elisabeth A. Murray (2017) Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments. Journal of Neuroscience Methods, 279:1-12
Alicia Izquierdo, Jonathan L. Brigman, Anna K. Radke, Peter H. Rudebeck, and Andrew Holmes (2017) The neural basis of reversal learning: An updated perspective. Neuroscience, 345:12-26
2016
Vincent D. Costa and Peter H. Rudebeck (2016) More than meets the eye: the relationship between pupil size and locus coerulus activity. Neuron, 89(1): 8-10
2015
Anthony I. Jang, Vincent D. Costa, Peter H. Rudebeck, Yogita Chudasama, Elisabeth A. Murray, and Bruno B. Averbeck (2015) The role of frontal cortical and medial-temporal lobe brain areas in learning a Bayesian prior belief on reversals, Journal of Neuroscience, 35(33): 11751-11760
Clayton Mosher and Peter H. Rudebeck (2015) New tricks for an old structure: the amygdala accountant. Nature Neuroscience, 18(3): 324-5
2014
Rudebeck, PH and Murray, E.A. (2014) The Orbitofrontal Oracle: Cortical Mechanisms for the Prediction and Evaluation of Specific Behavioral Outcomes. Neuron, 84(6):1143-1156 doi: 10.1016/j.neuron.2014.10.049.
Rudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA. A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the United States of America 2014 Apr; 111(14).
Tianming Yang, Rachel Bavley, Kevin Fomalont, Kevin Blomstrom, Andrew R Mitz, Janita Turchi, Peter H Rudebeck and Elisabeth A Murray (2014) Contributions of the hippocampus and entorhinal cortex to rapid associative learning in rhesus monkeys. Hippocampus, doi: 10.1002/hipo.22294.
Peter H Rudebeck, Philip T Putnam, Teresa E Daniels, Tianming Yang, Andrew R Mitz, Sarah EV Rhodes and Elisabeth A Murray (2014) A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the USA, 111(14): 5391-6.
2013
Peter H Rudebeck, Andrew R Mitz, Ravi V Chacko and Elisabeth A Murray (2013) Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex. Neuron, 80(6): 1519-31.
Peter H Rudebeck, Richard C Saunders, Anna T. Prescott, Lily S. Chau and Elisabeth A Murray (2013) Prefrontal mechanisms of emotion, value and behavioural flexibility. Nature Neuroscience, 16(8): 1140-5.
Elisabeth A Murray and Peter H Rudebeck (2013) Strive to drive: goal generation based on current needs. Frontiers in Neuroscience, 7: 112.
Alicia Izquierdo, Chelsi Darling, Nic Manos, Hilda Pozos, Charissa Kim, Serena Ostrander, Victor Cazares, Haley Stepp, Peter H Rudebeck (2013) Basolateral amygdala lesions facilitate and orbitofrontal cortex lesions impair responses after negative feedback in rats. Journal of Neuroscience, 33(9): 4105-9.
Yogita Chudasama, Teresa E Daniels, Daniel P Gorrin, Sarah EV Rhodes, Peter H Rudebeck, and Elisabeth A Murray (2013) Anterior cingulate cortex lesions in rhesus monkeys fail to disrupt choices guided by changes in reward value and reward contingency. Cerebral Cortex, 23(12): 2884-98.
2011
Peter H Rudebeck and Elisabeth A Murray (2011) Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting values. Annals of the New York Academy of Sciences, 1239(1): 1-13.
Mark E. Walton, Timothy E. J. Behrens, Peter H. Rudebeck, & Matthew F. S. Rushworth (2011) Cingulate and orbitofrontal contributions to valuing knowns and unknowns in a changeable world. Attention & Performance XXIII: Decision Making. OUP, Oxford.
Peter H Rudebeck and Elisabeth A Murray (2011) Dissociable effects of subtotal lesions within the macaque orbitofrontal cortex on reward-guided behaviour. Journal of Neuroscience, 31(29): 10569-10578.
2010 and before
MaryAnn P Noonan, Jerome Sallet, Peter H Rudebeck, Mark J Buckley, Matthew F Rushworth (2010) Does the medial orbitofrontal cortex have a role in social valuation? European Journal of Neuroscience, 31(12): 2341-51
Mark E Walton, Timothy E Behrens, Mark J Buckley, Peter H Rudebeck and Matthew FS Rushworth (2010) Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning. Neuron, 65(6): 927-39
Timothy Y Mariano, Mark G Baxter, Stephen B McHugh, Mark E Walton, Sarah R Rudebeck, Peter H Rudebeck, Matthew F Rushworth, J Nicholas Rawlins, Thomas G Campbell, David M Bannerman (2009) Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a non-spatial decision making maze task. European Journal of Neuroscience, 30(3): 472-84
Peter H Rudebeck, Timothy E Behrens, Steven W Kennerley, Mark G Baxter, Mark J Buckley, Mark E Walton, and Matthew F Rushworth (2008) Frontal cortex subregions play distinct roles in choices between actions and stimuli. Journal of Neuroscience, 28(51): 13775-85
Peter H Rudebeck, David M Bannerman, Matthew F Rushworth (2008) The contribution of distinct subregions of ventromedial frontal cortex to emotion, social behavior and decision-making. Cognitive, Affective and Behavioral Neuroscience 8 (4): 485-497
Peter H Rudebeck, Elisabeth A Murray (2008) Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learning. Journal of Neuroscience, 28(33): 8338–8343
Peter H Rudebeck, Mark E Walton, Benjamin HP Millette, Elizabeth Shirley, Matthew F Rushworth, David M Bannerman (2007) Distinct contributions of frontal areas to emotion and social behaviour. European Journal of Neuroscience, 26(8): 2315-26
Mark E Walton, Peter H Rudebeck, David M Bannerman, & Matthew F S Rushworth (2007) Calculating the cost of acting in the prefrontal cortex. Annals of the New York Academy of Science, 1104: 340-56
Matthew FS Rushworth, Timothy EJ Behrens, Peter H Rudebeck and Mark E Walton (2007) Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends in Cognitive Science, 11(4): 168-76
Peter H Rudebeck, Mark J Buckley, Mark E Walton and Matthew F Rushworth (2006) A role for the macaque anterior cingulate gyrus in social valuation. Science, 313(5791): 1310-2
Peter H Rudebeck, Mark E Walton, Angharad N Smyth, David B Bannerman, Matthew F Rushworth (2006) Separate neural pathways process different decision costs. Nature Neuroscience, 9(9): 1161-8
Narender Ramnani, Timothy EJ Behrens, Heidi Johansen-Berg, Marlene C Richter, Mark A Pinsk, Jesper LR Andersson, Peter Rudebeck, Olga Ciccarelli, Wolfgang Richter, Alan J Thompson, Charles G Gross, Mark D Robson, Sabine Kastner and Paul M Matthews (2005) The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from macaque monkeys and humans. Cerebral Cortex, 16(6): 811-8
Meet the Team
News, Funding, Job Opportunities
October, 2024 Five members of the Rudebeck lab present at SFN 2024 in Chicago
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August, 2024 Dr Davide Folloni awarded K99/R00 pathway to independence award “Neural mechanisms and modulation of affective states”! Congratulations, Davide!
April, 2024 Dr Zach Zeisler defends his PhD!
January, 2024 Lab presents at The Winter Conference on Brain Research in Breckenridge, CO.
August, 2023 Lab awarded two R01’s from the NIMH
- Title: Neural circuit mechanisms of affective probabilistic learning
- Title: Establishing the anatomical and functional mechanisms of white matter deep brain stimulation (with Helen Mayberg and Brian Russ)
June, 2023 The lab goes brain painting!
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April, 2023 Niranjana Bienkowska leaves the lab.
April, 2023 Dr Megan Fredericks receives her PhD!
January, 2022 Marques Love submits and passes his Masters thesis defense!
April, 2021 Lab awarded R34 from the BRAIN Initiative entitled “Comparative neuroanatomy at single neuron resolution.”
December, 2020 The lab goes ice skating
August, 2020 Dr Megan Young leaves the lab and moves to University of Toyama.
June, 2020 Lab re-opens!
March, 2020 COVID-19 Pandemic shuts the lab and everyone goes virtual.
November, 2019 Lab present at the OFC meeting in Paris
September, 2019. Lab awarded an R01 from the NIMH to study “Neural mechanisms of affective processing in prefrontal-limbic circuits”
July, 2019 Postdoctoral fellow Dr Catherine Elorette joins the lab
June, 2019 Master’s student Jairo Munoz passes his Masters thesis defense
May, 2019 PREP student Khadijah Crawford presents poster at North East PREP meeting
April, 2019 Postdoctoral fellow Dr Atsushi Fujimoto joins the lab on a Takeda Foundation Fellowship
January, 2019 With Rich and Rajan Labs, Rudebeck lab wins Di Sabato Family Research Fellowship from Friedman Brain Institute
October, 2018 Fred Stoll presents a poster at the Computational Properties of the Prefrontal Cortex (CPPC) meeting, in Nashville, TN
September, 2018 Lab receives joint BRAIN Initiative grant with Dr Brian Russ to study the mechanistic and causal basis of fMRI functional connectivity
April, 2018 Erin Rich, Fred and Pete publish review in Current Opinion in Neurobiology
November, 2017 Megan (Young), Fred, and Megan (Fredericks) present at the 2017 Society for Neuroscience meeting in Washington, DC
November, 2017 Pete wins the Janine Rosenberg Trubach Career Development Award from the Society for Neuroscience
November, 2017 Rudebeck Lab Escape the room!
September, 2017 PhD rotation students Joe Simon and Megan Fredericks as well as PREP student Khadijah Crawford join the lab
July, 2017 Rudebeck Lab conquer Bear Mountain!
08/01/2024-07/31/2027. (Rudebeck, MPI) Title: Determining the macro and microscale circuit-level basis of neuromodulation for OCD.
09/01/2023 – 08/31/2028. R01MH132789 (P. Rudebeck, MPI) NIMH, Title: Establishing the anatomical and functional mechanisms of white matter deep brain stimulation
08/01/2023 – 07/01/2028 R01MH132064 (Rudebeck, PI) NIMH, Title: Neural circuit mechanisms of affective probabilistic learning.
09/2019 – 08/2025 R01MH118638 (Rudebeck, PI) NIMH Title: Neural mechanisms of affective processing in prefrontal-limbic circuits.
Prospective research assistants, graduate students, or postdocs should reach out to the lab to see if there are any vacancies.