Genetic Interactions in the mTOR Network:

We utilise functional genomics to map the unique genetic architectures of nutrient-sensing pathways across diverse biological contexts. Our research has a particular focus on how these genetic interactions vary between tissues and cell types to dictate metabolic flexibility and disease susceptibility. By validating these networks in physiologically relevant in vivo models, we aim to uncover how context-specific mTOR signalling maintains organismal homeostasis or drives pathological states.

Antioxidant Biology and Cell Death:

We examine the function of protein and small-molecule antioxidants and their roles in modulating regulated cell death pathways. Our research focuses on defining how these systems regulate susceptibility to iron-dependent cell death (ferroptosis) within the physiological context of living tissues. By utilizing in vivo models, we aim to understand how the systemic metabolic environment dictates antioxidant defence mechanisms and disease outcomes in cancer, neurodegeneration, and aging.

Endocytic Trafficking for Theranostics:

We leverage the cell’s internal transport machinery to develop smart drugs and drug delivery systems. By engineering ligands that exploit specific endocytic pathways, we aim to develop improved therapeutics and delivery platforms to treat complex diseases.