We are interested in the neurobiological foundations underlying the causes, mechanisms, and trajectories of psychiatric and neurological disorders. Our work is deeply rooted in development. We take advantage of human pluripotent stem cells to reconstitute and understand human brain development. By developing new high-throughput in vitro model systems and employing single-cell omics approaches, we seek to understand how neural tissue is established during fetal development, how neurons form interconnected networks, and how they vary among individuals and in psychiatric and neurological disorders. We are committed to uncovering the regulatory networks that control stem cell differentiation and developing novel methods to increase the precision and safety of stem cell-based therapies. In addition to the in vitro model systems, we develop and use new experimentally tractable animal models of human disease to interrogate disease mechanisms and discover new therapeutic opportunities.
Sanchez-Priego C, Hu R, Boshans LL, Lalli M, Janas JA, Williams SE, Dong Z, Yang N, Cell Reports. 2022
Generation of Functional Human Oligodendrocytes from Dermal Fibroblasts by Direct Lineage Conversion
Cell Stem Cell. 2019 Oct 3;25(4):531-541.e6.