Featured Publications
2011 to 2023
Browne, C.J., Futamura, R., Minier-Toribio, A., Hicks, E.M., Ramakrishnan, A., Martínez-Rivera, F., Estill, M., Godino, A., Parise, E.M., Torres-Berrío, A., Cunningham, A.M., Hamilton, P.J., Walker, D.M., Huckins, L.M., Hurd, Y.L., Shen, L., and Nestler, E.J.Transcriptional signatures of heroin intake and seeking throughout the brain reward circuit. Science Advances, 9(23):eadg8558, 2023. PMCID: PMC10256172.
Rompala, G., Nagamatsu, S.T., Martínez-Magaña, J.J., Nuñez-Ríos, D.L., Wang, J., Girgenti, M.J., Krystal, J.H., Gelernter, J.; Traumatic Stress Brain Research Group; Hurd, Y.L., and Montalvo-Ortiz, J.L.Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications, 14(1):4544, 2023. PMCID: PMC10382503.
Ferland., J-M.N., Ellis, R.J., Betts, G., Silveira, M.M, de Firmino, J.B, Winstanley, C.A., and Hurd, Y.L.Long-term outcomes of adolescent THC exposure on translational cognitive measures in adulthood in an animal models and computational assessment of human data. JAMA Psychiatry, 80(1):66-76, 2023. PMCID: PMC9685552 (available on 2023-11-23).
Bassir Nia, A., Gibson, C.L., Spriggs, S.A., Jankowski, S.E., DeFrancisco, D., Swift, A., Perkel, C., Galynker, I., Honrao, C., Makriyannis, A., and Hurd. Y.L.Cannabis use is associated with low plasma endocannabinoid anandamide in individuals with psychosis. Journal of Psychopharmacology, Epub: Jan 12:2698811221148604, 2023.
Nomura, Y., Ham, J., Pehme, P.M., Wong, W., Pritchett, L., Rabinowitz, S., Foldi N.S., Hinton, V.J., Wickramaratne, P.J., and Hurd, Y.L. Association of maternal exposure to Superstorm Sandy and maternal cannabis use with development of psychopathology among offspring: The Stress in Pregnancy Study. BJPsych Open, 9(3):e94, 2023. PMCID: PMC10228222.
Nomura, Y., Newcorn, J.H., Ginalis, C., Heitz, C., Zaki, J., Khan, F., Nasrin, M., Sie, K., DeIngeniis, D., and Hurd, Y.L. Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: Stress in Pregnancy Study. Journal of Child Psychology and Psychiatry, epub: Sep 21, 2022. PMCID: PMC10027622 (available on 2024-07-01).
Szutorisz, H., and Hurd, Y.L. Overcoming addiction stigma: Epigenetic contributions to substance use disorders and opportunities for intervention. Neuron, 110(10):1611-1614, 2022.
Ferland., J-M.N., Ellis, R.J., Rompala, G., Landry, J.A., Callens, J.E., Ly A., Frier, M.D., Uzamere, T.O., and Hurd, Y.L. Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome. Molecular Psychiatry, Epub, Mar 2, 2022.
Ellis, R.J., Bara, A., Vargas, C.A., Frick, A.L., Loh, E., Landry, J., Uzamere, T.O., Callens, J.E., Martin, Q., Rajarajan, P., Brennand, K., Ramakrishnan, A., Shen, L., Szutorisz, H., and Hurd, Y.L. (2021). Prenatal Δ9-tetrahydrocannabinol exposure in males leads to motivational disturbances related to striatal epigenetic dysregulation. Biological Psychiatry, S0006-3223(21)01629-2, 2021. PMCID: PMC8957623.
Rompala, G., Nomura, Y., and Hurd, Y.L. Maternal cannabis use is associated with suppression of immune gene networks in placenta and increased anxiety phenotypes in offspring. Proceedings of the National Academy of Sciences of the United States of America, 118(47):e2106115118, 2021. PMCID: PMC8617511.
Bara, A., Ferland, J.N., Rompala, G., Szutorisz, H. and Hurd, Y.L. Cannabis and Synaptic Reprogramming of the Developing Brain. Nature Reviews Neuroscience, 22(7):423-438, 2021. PMCID: PMC8445589.
Nomura, Y., Rompala, G., Pritchett, L., Aushev, V., Chen, J., and Hurd, Y.L. (2021). Traumatic stress during pregnancy is linked to extensive reprogramming of the placental transcriptome in relation to anxiety and stress hormones in young children. Molecular Psychiatry, 26(11):6520-6530, 2021 PMCID: PMC8586067.
Randall J. Ellis, Tanni Rahman, Jeremy Sherman, Yasmin L. Hurd (2021). SnapShot: Neurobiology of opioid use disorder. Cell.
Ferland, J.N., and Hurd, Y.L. (2020). Deconstructing the neurobiology of cannabis use disorder. Nat Neurosci.
Hurd, Y.L (2020). Leading the Next CBD Wave-Safety and Efficacy. JAMA Psychiatry.
G.Egervari, Y.L.Hurd, et al. (2020). Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder. Nature Communications.
Hurd, Y. L., S. Spriggs, J. Alishayev, G. Winkel, K. Gurgov, C. Kudrich, A. M. Oprescu and E. Salsitz (2019). Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. Am J Psychiatry: appiajp201918101191.
Miller, M. L., B. Chadwick, D. L. Dickstein, I. Purushothaman, G. Egervari, T. Rahman, C. Tessereau, P. R. Hof, P. Roussos, L. Shen, M. G. Baxter and Y. L. Hurd (2019). Cell- and layer-specific transcriptomic strategy for characterizing the molecular phenotype of rat cortical neurons using laser capture microdissection and massively parallel RNA sequencing. Mol Psychiatry 24(4): 473.
Calipari, E. S., A. Godino, M. Salery, D. M. Damez-Werno, M. E. Cahill, C. T. Werner, A. M. Gancarz, E. G. Peck, Z. Jlayer, J. Rabkin, J. A. Landry, A. C. W. Smith, P. Defilippi, P. J. Kenny, Y. L. Hurd, R. L. Neve, D. M. Dietz and E. J. Nestler (2019). Synaptic microtubule-associated protein EB3 and SRC phosphorylation mediate structural and behavioral adaptations during withdrawal from cocaine self-administration. J Neurosci.
Anderson, S.A.R., Oprescu, A.M., Calello, D.P., Monte, A., Dayan, P.S., Hurd, Y.L., Manini, A.F., and Tox, I.C.I. (2019). Neuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid Toxicity. Pediatrics 144.
Bassir Nia, A., Mann, C.L., Spriggs, S., DeFrancisco, D.R., Carbonaro, S., Parvez, L., Galynker, II, Perkel, C.A., and Hurd, Y.L. (2019). The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population. J Clin Psychiatry 80.
Hu, J., Ly, J., Zhang, W., Huang, Y., Glover, V., Peter, I., Hurd, Y.L., and Nomura, Y. (2019). Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy. Dev Psychobiol 61, 640-649.
Hurd, Y.L., Manzoni, O.J., Pletnikov, M.V., Lee, F.S., Bhattacharyya, S., and Melis, M. (2019). Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects. J Neurosci 39, 8250-8258.
Egervari, G., Kozlenkov, A., Dracheva, S., and Hurd, Y.L. (2018b). Molecular windows into the human brain for psychiatric disorders. Mol Psychiatry.
Bassir Nia, A., and Hurd, Y.L. (2018). Cannabidiol, an Adjunct Player in the Antipsychosis Arsenal. Am J Psychiatry 175, 197-198.
Hurd, Y.L., and O’Brien, C.P. (2018). Molecular Genetics and New Medication Strategies for Opioid Addiction. Am J Psychiatry 175, 935-942.
Michaelides, M., Miller, M.L., Egervari, G., Primeaux, S.D., Gomez, J.L., Ellis, R.J., Landry, J.A., Szutorisz, H., Hoffman, A.F., Lupica, C.R., et al. (2018). Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. Mol Psychiatry.
Miller, M.L., Chadwick, B., Dickstein, D.L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P.R., Roussos, P., Shen, L., et al. (2018a). Adolescent exposure to Δ (9)-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons. Mol Psychiatry.
Szutorisz, H., and Hurd, Y.L. (2018). High times for cannabis: Epigenetic imprint and its legacy on brain and behavior. Neurosci Biobehav Rev 85, 93-101.
Egervari, G., Ciccocioppo, R., Jentsch, J.D., and Hurd, Y.L. (2018a). Shaping vulnerability to addiction – the contribution of behavior, neural circuits and molecular mechanisms. Neurosci Biobehav Rev 85, 117-125.
Mazzone, C.M., Pati, D., Michaelides, M., DiBerto, J., Fox, J.H., Tipton, G., Anderson, C., Duffy, K., McKlveen, J.M., Hardaway, J.A., et al. (2018). Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior. Mol Psychiatry 23, 143-153.
Miller, M.L., Ren, Y., Szutorisz, H., Warren, N.A., Tessereau, C., Egervari, G., Mlodnicka, A., Kapoor, M., Chaarani, B., Morris, C.V., et al. (2018b). Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. Mol Psychiatry 23, 1328-1335.
Fullard, J. F., M. E. Hauberg, J. Bendl, G. Egervari, M. D. Cirnaru, S. M. Reach, J. Motl, M. E. Ehrlich, Y. L. Hurd and P. Roussos (2018). An atlas of chromatin accessibility in the adult human brain. Genome Res 28(8): 1243-1252.
McKenzie, A. T., M. Wang, M. E. Hauberg, J. F. Fullard, A. Kozlenkov, A. Keenan, Y. L. Hurd, S. Dracheva, P. Casaccia, P. Roussos and B. Zhang (2018). Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. Sci Rep 8(1): 8868.
Hurd, Y.L. (2017). Cannabidiol: Swinging the Marijuana Pendulum From ‘Weed’ to Medication to Treat the Opioid Epidemic. Trends Neurosci 40, 124-127.
Miller, M.L., and Hurd, Y.L. (2017). Testing the Gateway Hypothesis. Neuropsychopharmacology 42, 985-986.
Cheer, J.F., and Hurd, Y.L. (2017). A new dawn in cannabinoid neurobiology: The road from molecules to therapeutic discoveries. Neuropharmacology 124, 1-2.
Michaelides, M., Miller, M.L., DiNieri, J.A., Gomez, J.L., Schwartz, E., Egervari, G., Wang, G.J., Mobbs, C.V., Volkow, N.D., and Hurd, Y.L. (2017). Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement. Neuropsychopharmacology 42, 2365-2376.
Egervari, G., Landry, J., Callens, J., Fullard, J.F., Roussos, P., Keller, E., and Hurd, Y.L. (2017). Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target. Biol Psychiatry 81, 585-594.
Bassir Nia, A., Medrano, B., Perkel, C., Galynker, I., and Hurd, Y.L. (2016). Psychiatric comorbidity associated with synthetic cannabinoid use compared to cannabis. J Psychopharmacol 30, 1321-1330.
Egervari, G., Jutras-Aswad, D., Landry, J., Miller, M.L., Anderson, S.A., Michaelides, M., Jacobs, M.M., Peter, C., Yiannoulos, G., Liu, X., et al. (2016). A Functional 3’UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits. Neuropsychopharmacology 41, 2512-2520.
Szutorisz, H., and Hurd, Y.L. (2016). Epigenetic Effects of Cannabis Exposure. Biol Psychiatry 79, 586-594.
Szutorisz, H., Egervari, G., Sperry, J., Carter, J.M., and Hurd, Y.L. (2016). Cross-generational THC exposure alters the developmental sensitivity of ventral and dorsal striatal gene expression in male and female offspring. Neurotoxicol Teratol 58, 107-114.
Watson, C.T., Szutorisz, H., Garg, P., Martin, Q., Landry, J.A., Sharp, A.J., and Hurd, Y.L. (2015). Genome-Wide DNA Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleus Accumbens Associated With Cross-Generational Effects of Adolescent THC Exposure. Neuropsychopharmacology 40, 2993-3005.
Parsons, L.H., and Hurd, Y.L. (2015). Endocannabinoid signalling in reward and addiction. Nat Rev Neurosci 16, 579-594.
Manini, A.F., Yiannoulos, G., Bergamaschi, M.M., Hernandez, S., Olmedo, R., Barnes, A.J., Winkel, G., Sinha, R., Jutras-Aswad, D., Huestis, M.A., et al. (2015). Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. J Addict Med 9, 204-210.
Hurd, Y.L., Yoon, M., Manini, A.F., Hernandez, S., Olmedo, R., Ostman, M., and Jutras-Aswad, D. (2015). Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage. Neurotherapeutics 12, 807-815.
Michaelides, M., and Hurd, Y.L. (2015). DREAMM: a biobehavioral imaging methodology for dynamic in vivo whole-brain mapping of cell type-specific functional networks. Neuropsychopharmacology 40, 239-240.
Xu, J., Lu, Z., Xu, M., Pan, L., Deng, Y., Xie, X., Liu, H., Ding, S., Hurd, Y.L., Pasternak, G.W., et al. (2014). A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the mu opioid receptor gene OPRM1 via hnRNPH interactions. J Neurosci 34, 11048-11066.
Alpar, A., Tortoriello, G., Calvigioni, D., Niphakis, M.J., Milenkovic, I., Bakker, J., Cameron, G.A., Hanics, J., Morris, C.V., Fuzik, J., et al. (2014). Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun 5, 4421.
Maze, I., Chaudhury, D., Dietz, D.M., Von Schimmelmann, M., Kennedy, P.J., Lobo, M.K., Sillivan, S.E., Miller, M.L., Bagot, R.C., Sun, H., et al. (2014). G9a influences neuronal subtype specification in striatum. Nat Neurosci 17, 533-539.
Szutorisz, H., DiNieri, J.A., Sweet, E., Egervari, G., Michaelides, M., Carter, J.M., Ren, Y., Miller, M.L., Blitzer, R.D., and Hurd, Y.L. (2014). Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation. Neuropsychopharmacology 39, 1315-1323.
Tortoriello, G., Morris, C.V., Alpar, A., Fuzik, J., Shirran, S.L., Calvigioni, D., Keimpema, E., Botting, C.H., Reinecke, K., Herdegen, T., et al. (2014). Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J 33, 668-685.
Trampush, J.W., Jacobs, M.M., Hurd, Y.L., Newcorn, J.H., and Halperin, J.M. (2014). Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development. Dev Sci 17, 584-595.
Kozlenkov, A., Roussos, P., Timashpolsky, A., Barbu, M., Rudchenko, S., Bibikova, M., Klotzle, B., Byne, W., Lyddon, R., Di Narzo, A.F., et al. (2014). Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic Acids Res 42, 109-127.
Mitchell, A.C., Bharadwaj, R., Whittle, C., Krueger, W., Mirnics, K., Hurd, Y., Rasmussen, T., and Akbarian, S. (2014). The genome in three dimensions: a new frontier in human brain research. Biol Psychiatry 75, 961-969.
Hurd, Y.L., Michaelides, M., Miller, M.L., and Jutras-Aswad, D. (2014). Trajectory of adolescent cannabis use on addiction vulnerability. Neuropharmacology 76 Pt B, 416-424.
Michaelides, M., Anderson, S.A., Ananth, M., Smirnov, D., Thanos, P.K., Neumaier, J.F., Wang, G.J., Volkow, N.D., and Hurd, Y.L. (2013). Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest 123, 5342-5350.
Anderson, S.A., Michaelides, M., Zarnegar, P., Ren, Y., Fagergren, P., Thanos, P.K., Wang, G.J., Bannon, M., Neumaier, J.F., Keller, E., et al. (2013). Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J Clin Invest 123, 5334-5341.
Karatsoreos, I.N., Thaler, J.P., Borgland, S.L., Champagne, F.A., Hurd, Y.L., and Hill, M.N. (2013). Food for thought: hormonal, experiential, and neural influences on feeding and obesity. J Neurosci 33, 17610-17616.
Chadwick, B., Miller, M.L., and Hurd, Y.L. (2013). Cannabis Use during Adolescent Development: Susceptibility to Psychiatric Illness. Front Psychiatry 4, 129.
Lobo, M.K., Zaman, S., Damez-Werno, D.M., Koo, J.W., Bagot, R.C., DiNieri, J.A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013). ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci 33, 18381-18395.
Keimpema, E., Alpar, A., Howell, F., Malenczyk, K., Hobbs, C., Hurd, Y.L., Watanabe, M., Sakimura, K., Kano, M., Doherty, P., et al. (2013). Diacylglycerol lipase alpha manipulation reveals developmental roles for intercellular endocannabinoid signaling. Sci Rep 3, 2093.
Sillivan, S.E., Whittard, J.D., Jacobs, M.M., Ren, Y., Mazloom, A.R., Caputi, F.F., Horvath, M., Keller, E., Ma’ayan, A., Pan, Y.X., et al. (2013). ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers. Biol Psychiatry 74, 511-519.
Manini, A.F., Jacobs, M.M., Vlahov, D., and Hurd, Y.L. (2013b). Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. J Med Toxicol 9, 148-154.
Bergamaschi, M.M., Barnes, A., Queiroz, R.H., Hurd, Y.L., and Huestis, M.A. (2013). Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine. Anal Bioanal Chem 405, 4679-4689.
Manini, A., Jacobs, M., Vlahov, D., and Hurd, Y. (2013a). On the role of genetic testing for personalized drug overdose management. J Med Toxicol 9, 294-295.
Jacobs, M.M., Okvist, A., Horvath, M., Keller, E., Bannon, M.J., Morgello, S., and Hurd, Y.L. (2013). Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels. Mol Psychiatry 18, 1205-1210.
Tomasiewicz, H.C., Jacobs, M.M., Wilkinson, M.B., Wilson, S.P., Nestler, E.J., and Hurd, Y.L. (2012). Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol Psychiatry 72, 803-810.
Jutras-Aswad, D., Jacobs, M.M., Yiannoulos, G., Roussos, P., Bitsios, P., Nomura, Y., Liu, X., and Hurd, Y.L. (2012). Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. PLoS One 7, e39243.
Dinieri, J.A., and Hurd, Y.L. (2012). Rat models of prenatal and adolescent cannabis exposure. Methods Mol Biol 829, 231-242.
DiNieri, J.A., Wang, X., Szutorisz, H., Spano, S.M., Kaur, J., Casaccia, P., Dow-Edwards, D., and Hurd, Y.L. (2011). Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring. Biol Psychiatry 70, 763-769.
Okvist, A., Fagergren, P., Whittard, J., Garcia-Osta, A., Drakenberg, K., Horvath, M.C., Schmidt, C.J., Keller, E., Bannon, M.J., and Hurd, Y.L. (2011). Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers. Biol Psychiatry 69, 245-252.
Morris, C.V., DiNieri, J.A., Szutorisz, H., and Hurd, Y.L. (2011). Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment. Eur J Neurosci 34, 1574-1583.