Brain tumors remain a deadly form of cancer. Our research goal is to provide a better understanding of the molecular machinery that drives proliferation, invasiveness, and therapy resistance of brain tumor cells. We aim to provide insights that will allow development of new targeted therapies against brain tumor cells.
Our research team focuses on the question of how axon guidance molecules regulate migration and proliferation of brain tumor cells. We are also investigating the molecular characteristics that define brain tumor stem cells by using molecular reporters.
Tumors of the brain are amongst the most lethal types of cancer. They account for over 175,000 cases per year worldwide, claiming the lives of thousands of patients (WHO World Cancer Report). Despite significant progress in the identification of genes involved in tumorigenesis, the etiology of brain tumors is still largely unknown, and incidence and mortality rates of these cancers have changed little over the past decade. The goal of our research is to identify the genetic factors that contribute to the formation and spreading of brain tumors. The identification of novel diagnostic markers and therapeutic targets will lead to better treatment strategies for this devastating disease.
Axon guidance molecules control cellular dynamics and malignancy of glioma cells
Cellular and molecular characteristics of glioblastoma stem cells
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment
Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. Our studies on the cellular and molecular features of quiescent GBM cells, by using a 3D GBM organoid system and an engineered knock-in of an H2B-GFP proliferation reporter, provide a starting point for developing strategies to tackle this critical population of GBM.
Rut Tejero, Yong Huang, Igor Katsyv, Michael Kluge, Jung-Yi Lin, Jessica Tome-Garcia, Nicolas Daviaud, Yuanshuo Wang, Bin Zhang, Nadejda M. Tsankova, Caroline C. Friedel, Hongyan Zou, and Roland H. Friedel
Meet the Team