Rich Lab

Neurophysiology of Affect and Cognition

Research

erin rich headshotEstimates of how good or bad something will be influence how we experience the world, impacting our actions, choices, attention and memory. Our lab is interested in how the brain processes affective information, in other words the “goodness” or “badness” of experiences, and how this interacts with cognitive processes. Our studies combine hypothesis-driven behavioral designs with large-scale neurophysiological recordings to understand how neural dynamics give rise to behavior and cognition.

Contact Us

Rich Laboratory
Erin L Rich, MD, PhD
Assistant Professor, Neuroscience
Location
Office: HESS CSM 10-115
Phone
Office: 212.824.9304
Email

Publications

2017

Caudate Microstimulation Increases Value of Specific Choices.

Santacruz SR, Rich EL, Wallis JD, Carmena JM. Curr Biol. 2017 Nov 6;27(21):3375-3383.e3. Epub 2017 Oct 26. PMID: 29107551


Spatiotemporal dynamics of information encoding revealed in orbitofrontal high-gamma. 

Rich EL, Wallis JD. Nat Commun. 2017 Oct 26;8(1):1139. PMID: 29074960

2016

natneuro jul2016 coverDecoding subjective decisions from orbitofrontal cortex.
Rich EL, Wallis JD.
Nat Neurosci. 2016 Jul;19(7):973-80. doi: 10.1038/nn.4320. Epub 2016 Jun 6. PMID 27273768

                    Faculty of 1000 review


What stays the same in orbitofrontal cortex.
Rich EL, Wallis JD.
Nat Neurosci. 2016 May 26;19(6):768-70. doi: 10.1038/nn.4305. No abstract available.PMID: 27227365.

2014

Medial-lateral organization of the orbitofrontal cortex.
Rich EL, Wallis JD.
J Cogn Neurosci. 2014 Jul;26(7):1347-62. doi: 10.1162/jocn_a_00573. Epub 2014 Jan 9. PMID: 24405106

2013

Prefrontal-amygdala interactions underlying value coding.
Rich EL, Wallis JD.
Neuron. 2013 Dec 18;80(6):1344-6. doi: 10.1016/j.neuron.2013.11.027. PMID: 24360539

2012

jpsychres coverStriatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences.
Perez-Rodriguez MM, Hazlett EA, Rich EL, Ripoll LH, Weiner DM, Spence N, Goodman M, Koenigsberg HW, Siever LJ, New AS.
J Psychiatr Res. 2012 Jun;46(6):797-804. doi: 10.1016/j.jpsychires.2012.02.014. Epub 2012 Mar 29. PMID: 22464337

2011

Challenges of Interpreting Frontal Neurons during Value-Based Decision-Making.
Wallis JD, Rich EL.
Front Neurosci. 2011 Nov 22;5:124. doi: 10.3389/fnins.2011.00124. eCollection 2011. PMID: 22125508

2009 & earlier

jneurosci jun2009 coverRat prefrontal cortical neurons selectively code strategy switches.
Rich EL, Shapiro M.
J Neurosci. 2009 Jun 3;29(22):7208-19. doi: 10.1523/JNEUROSCI.6068-08.2009. PMID: 19494143

Faculty of 1000 review


jneurosci sept2008 coverThe neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism.
Bozdagi O, Rich E, Tronel S, Sadahiro M, Patterson K, Shapiro ML, Alberini CM, Huntley GW, Salton SR.
J Neurosci. 2008 Sep 24;28(39):9857-69. doi: 10.1523/JNEUROSCI.3145-08.2008. PMID: 18815270

Faculty of 1000 review


Prelimbic/infralimbic inactivation impairs memory for multiple task switches, but not flexible selection of familiar tasks.
Rich EL, Shapiro ML.
J Neurosci. 2007 Apr 25;27(17):4747-55. PMID: 17460087

 

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Photoperiodically-induced changes in hypothalamic-pituitary-adrenal axis sensitivity in captive house sparrows (Passer domesticus).

Romero LM, Rich EL. Comp Biochem Physiol A Mol Integr Physiol. 2007 Jun;147(2):562-8. Epub 2007 Feb 11. PMID: 17363309

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Exposure to chronic stress downregulates corticosterone responses to acute stressors.

Rich EL, Romero LM. Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1628-36. PMID: 15886358

                          Faculty of 1000 review

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Daily and photoperiod variations of basal and stress-induced corticosterone concentrations in house sparrows (Passer domesticus).

Rich EL, Romero LM. J Comp Physiol B. 2001 Oct;171(7):543-7. PMID: 11686612

Meet the Team

Feng-Kuei Chiang

Postdoctoral Fellow

I am interested in cognitive functions of prefrontal cortex, which include working memory, hierarchical learning, and decision-making. Mainly, how prefrontal areas dynamically encode a series of actions/events under the sequential or hierarchical tasks.

feng-kuei.chiang (at) mssm (dot) edu

Pierre Enel

Pierre Enel

Postdoctoral Fellow

Computational modeling of decision circuits

pierre.enel (at) mssm (dot) edu

Zach Gillis

Zach Gillis

Research Assistant

zachary.gillis (at) mssm (dot) edu

Prefrontal and temporal science initiative

(a.k.a. Baxter, Croxson, Rich, and Rudebeck Labs)

Funding & Awards

K08 Mentored Clinical Scientist Research Development Award (NIDA, DA039351)