Rudebeck Lab

Neurobiology of Emotion & Cognition

Research

rudebeckIn our daily lives we often encounter both pleasurable and aversive situations, which heighten our emotional state and affect cognition. The ability to flexibly regulate our emotions in response to such events is essential for adapting to our environment and, ultimately, for our mental health. Many forms of mental illness involve dysfunction in the neural systems that regulate affective processing and decision making. The limbic system, which includes parts of the prefrontal cortex and medial temporal lobe, is critical for regulating emotions and plays an essential role in cognition. The main focus of the Rudebeck lab is to understand how interaction between the prefrontal cortex and subcortical structures such as the amygdala contribute to emotional regulation and decision-making. To do this, we use a combination of behavioral, autonomic, neurophysiological and interference methods in animal models.

Contact Us

Rudebeck Laboratory
Peter H Rudebeck, PhD
Professor, Neuroscience
Professor, Psychiatry
Location
Lab: HESS CSM 10-203A
Office: HESS CSM 10-112
Phone
Office: 212.824.9307
Lab: 212.824.9184
Email

Featured

Featured Publications

A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Rudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA (2014) PNAS 111(14) 5391–5396

Publications

In press / BioRxiv

Erin L. Rich, Frederic M. Stoll, and Peter H. Rudebeck (2018) Linking dynamic patterns of neural activity in orbitofrontal cortex with decision making. Current Opinion in Neurobiology. 49:24-32


Frederic M. Stoll, Clayton P. Mosher, Sarita Tamang, Elisabeth A. Murray, and Peter H. Rudebeck (2017) Amygdala plays distinct roles on prefrontal local field potential and single neuron encoding of reward-based decisions. (http://www.biorxiv.org/content/early/2017/04/21/129221)


James J Young, Peter H Rudebeck, Lara V Marcuse, Madeline C Fields, Ji Yeoun Yoo, Fedor Panov, Saadi Ghatan, Arash Fazl, Sarah Mandelbaum, Mark G Baxter (2017) A Theta Band Network Involving Prefrontal Cortex Unique to Human Episodic Memory. (http://www.biorxiv.org/content/early/2017/05/19/140251.1)


Jamie Nagy, Mark G. Baxter, Christienne Damatac, Peter H. Rudebeck, and Paula L. Croxson (2017) Lack of sex differences in higher cognitive function in macaques. (http://www.biorxiv.org/content/early/2017/06/21/153593)

2017

Peter H. Rudebeck, Richard C. Saunders, Dawn A. Lundgren, and Elisabeth A. Murray (2017) Specialized representations of value in orbital and ventrolateral prefrontal cortex: desirability versus availability of outcomes. Neuron, 95(5): 1208-1220


Peter H. Rudebeck, Joshua A. Ripple, Andrew R. Mitz, Bruno B. Averbeck, and Elisabeth A. Murray (2017) Amygdala contributions to stimulus–reward encoding in the macaque medial and orbital frontal cortex during learning. Journal of Neuroscience, 37(8): 2186-2202


Andrew R. Mitz, Ravi V. Chako, Philip T. Putnam, Peter H. Rudebeck, and Elisabeth A. Murray (2017) Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments. Journal of Neuroscience Methods, 279:1-12


Alicia Izquierdo, Jonathan L. Brigman, Anna K. Radke, Peter H. Rudebeck, and Andrew Holmes (2017) The neural basis of reversal learning: An updated perspective. Neuroscience, 345:12-26

2016
Vincent D. Costa and Peter H. Rudebeck (2016) More than meets the eye: the relationship between pupil size and locus coerulus activity. Neuron, 89(1): 8-10
2015

Anthony I. Jang, Vincent D. Costa, Peter H. Rudebeck, Yogita Chudasama, Elisabeth A. Murray, and Bruno B. Averbeck (2015) The role of frontal cortical and medial-temporal lobe brain areas in learning a Bayesian prior belief on reversals, Journal of Neuroscience, 35(33): 11751-11760


Clayton Mosher and Peter H. Rudebeck (2015) New tricks for an old structure: the amygdala accountant. Nature Neuroscience, 18(3): 324-5

2014

neuron dec 2014 vol84-6Rudebeck, PH and Murray, E.A. (2014) The Orbitofrontal Oracle: Cortical Mechanisms for the Prediction and Evaluation of Specific Behavioral Outcomes. Neuron, 84(6):1143-1156 doi: 10.1016/j.neuron.2014.10.049.


pnas 04 2014 vol111 14 coverRudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA. A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the United States of America 2014 Apr; 111(14).


hippocampusTianming Yang, Rachel Bavley, Kevin Fomalont, Kevin Blomstrom, Andrew R Mitz, Janita Turchi, Peter H Rudebeck and Elisabeth A Murray (2014) Contributions of the hippocampus and entorhinal cortex to rapid associative learning in rhesus monkeys. Hippocampus, doi: 10.1002/hipo.22294.


Peter H Rudebeck, Philip T Putnam, Teresa E Daniels, Tianming Yang, Andrew R Mitz, Sarah EV Rhodes and Elisabeth A Murray (2014) A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the USA, 111(14): 5391-6.

2013

Peter H Rudebeck, Andrew R Mitz, Ravi V Chacko and Elisabeth A Murray (2013) Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex. Neuron, 80(6): 1519-31.


Peter H Rudebeck, Richard C Saunders, Anna T. Prescott, Lily S. Chau and Elisabeth A Murray (2013) Prefrontal mechanisms of emotion, value and behavioural flexibility. Nature Neuroscience, 16(8): 1140-5.


Elisabeth A Murray and Peter H Rudebeck (2013) Strive to drive: goal generation based on current needs. Frontiers in Neuroscience, 7: 112.


Alicia Izquierdo, Chelsi Darling, Nic Manos, Hilda Pozos, Charissa Kim, Serena Ostrander, Victor Cazares, Haley Stepp, Peter H Rudebeck (2013) Basolateral amygdala lesions facilitate and orbitofrontal cortex lesions impair responses after negative feedback in rats. Journal of Neuroscience, 33(9): 4105-9.


Yogita Chudasama, Teresa E Daniels, Daniel P Gorrin, Sarah EV Rhodes, Peter H Rudebeck, and Elisabeth A Murray (2013) Anterior cingulate cortex lesions in rhesus monkeys fail to disrupt choices guided by changes in reward value and reward contingency. Cerebral Cortex, 23(12): 2884-98.

2011

Peter H Rudebeck and Elisabeth A Murray (2011) Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting values. Annals of the New York Academy of Sciences, 1239(1): 1-13.


Mark E. Walton, Timothy E. J. Behrens, Peter H. Rudebeck, & Matthew F. S. Rushworth (2011) Cingulate and orbitofrontal contributions to valuing knowns and unknowns in a changeable world. Attention & Performance XXIII: Decision Making. OUP, Oxford.


Peter H Rudebeck and Elisabeth A Murray (2011) Dissociable effects of subtotal lesions within the macaque orbitofrontal cortex on reward-guided behaviour. Journal of Neuroscience, 31(29): 10569-10578.

2010 and before

MaryAnn P Noonan, Jerome Sallet, Peter H Rudebeck, Mark J Buckley, Matthew F Rushworth (2010) Does the medial orbitofrontal cortex have a role in social valuation? European Journal of Neuroscience, 31(12): 2341-51


Mark E Walton, Timothy E Behrens, Mark J Buckley, Peter H Rudebeck and Matthew FS Rushworth (2010) Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning. Neuron, 65(6): 927-39


Timothy Y Mariano, Mark G Baxter, Stephen B McHugh, Mark E Walton, Sarah R Rudebeck, Peter H Rudebeck, Matthew F Rushworth, J Nicholas Rawlins, Thomas G Campbell, David M Bannerman (2009) Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a non-spatial decision making maze task. European Journal of Neuroscience, 30(3): 472-84


Peter H Rudebeck, Timothy E Behrens, Steven W Kennerley, Mark G Baxter, Mark J Buckley, Mark E Walton, and Matthew F Rushworth (2008) Frontal cortex subregions play distinct roles in choices between actions and stimuli. Journal of Neuroscience, 28(51): 13775-85


Peter H Rudebeck, David M Bannerman, Matthew F Rushworth (2008) The contribution of distinct subregions of ventromedial frontal cortex to emotion, social behavior and decision-making. Cognitive, Affective and Behavioral Neuroscience 8 (4): 485-497


Peter H Rudebeck, Elisabeth A Murray (2008) Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learning. Journal of Neuroscience, 28(33): 8338–8343


Peter H Rudebeck, Mark E Walton, Benjamin HP Millette, Elizabeth Shirley, Matthew F Rushworth, David M Bannerman (2007) Distinct contributions of frontal areas to emotion and social behaviour. European Journal of Neuroscience, 26(8): 2315-26


Mark E Walton, Peter H Rudebeck, David M Bannerman, & Matthew F S Rushworth (2007) Calculating the cost of acting in the prefrontal cortex. Annals of the New York Academy of Science, 1104: 340-56


Matthew FS Rushworth, Timothy EJ Behrens, Peter H Rudebeck and Mark E Walton (2007) Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends in Cognitive Science, 11(4): 168-76


Peter H Rudebeck, Mark J Buckley, Mark E Walton and Matthew F Rushworth (2006) A role for the macaque anterior cingulate gyrus in social valuation. Science, 313(5791): 1310-2


Peter H Rudebeck, Mark E Walton, Angharad N Smyth, David B Bannerman, Matthew F Rushworth (2006) Separate neural pathways process different decision costs. Nature Neuroscience, 9(9): 1161-8


Narender Ramnani, Timothy EJ Behrens, Heidi Johansen-Berg, Marlene C Richter, Mark A Pinsk, Jesper LR Andersson, Peter Rudebeck, Olga Ciccarelli, Wolfgang Richter, Alan J Thompson, Charles G Gross, Mark D Robson, Sabine Kastner and Paul M Matthews (2005) The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from macaque monkeys and humans. Cerebral Cortex, 16(6): 811-8

Meet the Team

Megan E. Young, PhD

Megan E. Young, PhD

Postdoctoral Fellow

megan.young@mssm.edu
Kristen Esannason

Kristen Esannason

Associate Researcher

Email: kristen.esannason@mssm.edu
Danilo Perez

Danilo Perez

PhD Rotation Student

danilo.perez@icahn.mssm.edu
Frederic M Stoll, PhD

Frederic M Stoll, PhD

Postdoctoral Fellow

frederic.stoll@mssm.edu
Khadijah Crawford

Khadijah Crawford

PREP Student

khadijah.crawford@icahn.mssm.edu
Joe Simon

Joe Simon

PhD Rotation Student

joseph.simon@icahn.mssm.edu
J. Megan Fredericks

J. Megan Fredericks

PhD Student

megan.fredericks@icahn.mssm.edu
Jairo Munoz

Jairo Munoz

Masters Student

jairo.munoz@icahn.mssm.edu

News, Funding, Job Opportunities

November, 2017       PhD rotation student Danilo Perez joins the lab


November, 2017       Megan (Young), Fred, and Megan (Fredericks) present at the 2017 Society for Neuroscience meeting in Washington, DC


November, 2017      Pete wins the Janine Rosenberg Trubach Career Development Award from the Society for Neuroscience


November, 2017      Rudebeck Lab Escape the room!


September, 2017       PhD rotation students Joe Simon and Megan Fredericks as well as PREP student Khadijah Crawford join the lab


July, 2017                  Rudebeck Lab conquer Bear Mountain!


01/15/2016 – 01/14/2018      Young Investigator Award Brain (Rudebeck, PI)
Behavior Research Foundation
Title: The Neurophysiology of Anhedonia
Goal: To determine how neural activity in a circuit linking prefrontal cortex and
limbic system is related to the anticipation of reward.



07/01/2016 – 3/31/2021        R01MH110822 (Rudebeck, PI)
NIMH Biobehavioral Research Awards for Innovative New Scientists (BRAINS)
Title: A new approach to the role of prefrontal-limbic circuits in anxiety disorders.
Goal: To determine the mechanistic and causal basis of how the brain processes
information about the potential for both negative and positive events to occur.



03/24/2017 – 02/28/2019          R21MH112539 (Rudebeck,PI)
NIMH
Title: Neural mechanisms of social affect induction
Goal: To determine how inducing temporally extended affective states in macaque
monkeys affects activity in circuits linking prefrontal cortex and limbic system.

 


02/2017 – 02/2018                     Rosen Family Scholar
Friedman Brain Institute Scholars
Title: Neural mechanisms of human higher cognitive function
Goal: This project aims to determine the patterns of neural activity, both single
neuron and local field potentials, that support working memory in humans.

There are no specific positions that we are looking to recruit for at the moment, but we are always looking for talented MSc, PhD students, and postdocs to join the lab, so please get in contact.