In our daily lives we often encounter both pleasurable and aversive situations, which heighten our emotional state and affect cognition. The ability to flexibly regulate our emotions in response to such events is essential for adapting to our environment and, ultimately, for our mental health. Many forms of mental illness involve dysfunction in the neural systems that regulate affective processing and decision making. The limbic system, which includes parts of the prefrontal cortex and medial temporal lobe, is critical for regulating emotions and plays an essential role in cognition. The main focus of the Rudebeck lab is to understand how interaction between the prefrontal cortex and subcortical structures such as the amygdala contribute to emotional regulation and decision-making. To do this, we use a combination of behavioral, autonomic, neurophysiological and interference methods in animal models.
The subgenual anterior cingulate cortex (subgenual ACC) plays an important role in regulating emotion, and degeneration in this area correlates with depressed mood and anhedonia. Despite this understanding, it remains unknown how this part of the prefrontal cortex causally contributes to emotion, especially positive emotions.
Orbitofrontal Cortex: Prediction and Evaluation of Behavioral Outcomes
Vincent D. Costa and Peter H. Rudebeck (2016) More than meets the eye: the relationship between pupil size and locus coerulus activity. Neuron, 89(1): 8-10
Anthony I. Jang, Vincent D. Costa, Peter H. Rudebeck, Yogita Chudasama, Elisabeth A. Murray, and Bruno B. Averbeck (2015) The role of frontal cortical and medial-temporal lobe brain areas in learning a Bayesian prior belief on reversals, Journal of Neuroscience, 35(33): 11751-11760
Clayton Mosher and Peter H. Rudebeck (2015) New tricks for an old structure: the amygdala accountant. Nature Neuroscience, 18(3): 324-5
Rudebeck, PH and Murray, E.A. (2014) The Orbitofrontal Oracle: Cortical Mechanisms for the Prediction and Evaluation of Specific Behavioral Outcomes. Neuron, 84(6):1143-1156 doi: 10.1016/j.neuron.2014.10.049.
Rudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA. A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the United States of America 2014 Apr; 111(14).
Tianming Yang, Rachel Bavley, Kevin Fomalont, Kevin Blomstrom, Andrew R Mitz, Janita Turchi, Peter H Rudebeck and Elisabeth A Murray (2014) Contributions of the hippocampus and entorhinal cortex to rapid associative learning in rhesus monkeys. Hippocampus, doi: 10.1002/hipo.22294.
Peter H Rudebeck, Philip T Putnam, Teresa E Daniels, Tianming Yang, Andrew R Mitz, Sarah EV Rhodes and Elisabeth A Murray (2014) A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the USA, 111(14): 5391-6.
Peter H Rudebeck, Andrew R Mitz, Ravi V Chacko and Elisabeth A Murray (2013) Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex. Neuron, 80(6): 1519-31.
Peter H Rudebeck, Richard C Saunders, Anna T. Prescott, Lily S. Chau and Elisabeth A Murray (2013) Prefrontal mechanisms of emotion, value and behavioural flexibility. Nature Neuroscience, 16(8): 1140-5.
Elisabeth A Murray and Peter H Rudebeck (2013) Strive to drive: goal generation based on current needs. Frontiers in Neuroscience, 7: 112.
Alicia Izquierdo, Chelsi Darling, Nic Manos, Hilda Pozos, Charissa Kim, Serena Ostrander, Victor Cazares, Haley Stepp, Peter H Rudebeck (2013) Basolateral amygdala lesions facilitate and orbitofrontal cortex lesions impair responses after negative feedback in rats. Journal of Neuroscience, 33(9): 4105-9.
Yogita Chudasama, Teresa E Daniels, Daniel P Gorrin, Sarah EV Rhodes, Peter H Rudebeck, and Elisabeth A Murray (2013) Anterior cingulate cortex lesions in rhesus monkeys fail to disrupt choices guided by changes in reward value and reward contingency. Cerebral Cortex, 23(12): 2884-98.
Peter H Rudebeck and Elisabeth A Murray (2011) Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting values. Annals of the New York Academy of Sciences, 1239(1): 1-13.
Mark E. Walton, Timothy E. J. Behrens, Peter H. Rudebeck, & Matthew F. S. Rushworth (2011) Cingulate and orbitofrontal contributions to valuing knowns and unknowns in a changeable world. Attention & Performance XXIII: Decision Making. OUP, Oxford.
Peter H Rudebeck and Elisabeth A Murray (2011) Dissociable effects of subtotal lesions within the macaque orbitofrontal cortex on reward-guided behaviour. Journal of Neuroscience, 31(29): 10569-10578.